| 刘平闯,张文辉,王 迪,孙宜田,张灿堂,陈玉玲.非小细胞肺癌组织MAGEA4、NY-ESO-1表达
及其与临床病理特征和预后的关系[J].,2024,(22):4333-4335 |
| 非小细胞肺癌组织MAGEA4、NY-ESO-1表达
及其与临床病理特征和预后的关系 |
| Expression of MAGEA4 and NY-ESO-1 in Non-Small Cell Lung Cancer and Their Relationship with Clinicopathological Features and Prognosis |
| 投稿时间：2024-07-02 修订日期：2024-07-30 |
| DOI：10.13241/j.cnki.pmb.2024.22.039 |
| 中文关键词: 非小细胞肺癌 黑素瘤相关抗原A4 纽约食管鳞状上皮癌抗原1 病理特征 预后 |
| 英文关键词: Non-small cell lung cancer Melanoma-associated antigen A4 New York esophageal squamous cell carcinoma antigen 1 Pathological features Prognosis |
| 基金项目:江苏省高校重点实验室开放课题（XZSYSKF2023018） |
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| 中文摘要: |
| 摘要 目的：探讨非小细胞肺癌（NSCLC）组织黑素瘤相关抗原A4（MAGEA4）、纽约食管鳞状上皮癌抗原1（NY-ESO-1）表达与临床病理特征和预后的关系。方法：选取我院309例NSCLC患者，取手术切除的癌组织和癌旁组织检测MAGEA4和NY-ESO-1表达。比较不同临床病理特征NSCLC组织中MAGEA4、NY-ESO-1表达差异。随访3年，分析MAGEA4、NY-ESO-1表达与NSCLC患者预后的关系以及影响NSCLC患者预后的因素。结果：NSCLC癌组织MAGEA4、NY-ESO-1的阳性表达率高于癌旁组织（P＜0.05）。NSCLC患者中MAGEA4、NY-ESO-1阳性表达率增高与低分化、TNM分期ⅢA期、淋巴结转移有关（P＜0.05）。MAGEA4、NY-ESO-1阳性表达3年总生存（OS）率低于MAGEA4、NY-ESO-1阴性表达患者（P＜0.05）。MAGEA4阳性表达、淋巴结转移、TNM分期ⅢA期、NY-ESO-1阳性表达是NSCLC患者不良预后的危险因素（P＜0.05）。结论：NSCLC组织中MAGEA4和NY-ESO-1阳性表达率升高，与淋巴结转移、TNM分期ⅢA期、低分化和NSCLC患者不良预后有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the expression of melanoma-associated antigen A4 (MAGEA4) and New York esophageal squamous cell carcinoma antigen 1 (NY-ESO-1) in non-small cell lung cancer (NSCLC) tissues and clinicopathological features and prognosis. Methods: 309 NSCLC patients in our hopital were selected, surgically resected cancer tissues and adjacent tissues were taken, the expression of MAGEA4 and NY-ESO-1 was detected. The expression differences of MAGEA4 and NY-ESO-1 in NSCLC tissues with different clinicopathological features were compared. Followed up for 3 years, the relationship between MAGEA4 and NY-ESO-1 expression and prognosis of NSCLC patients and the factors affecting prognosis of NSCLC patients were analyzed. Results: The positive expression rates of MAGEA4 and NY-ESO-1 in NSCLC cancer tissues were higher than in adjacent tissues (P<0.05). The increased positive expression rates of MAGEA4 and NY-ESO-1 in NSCLC patients were associated with low differentiation, TNM stage ⅢA, and lymph node metastasis (P<0.05). The 3-year overall survival (OS) rate of MAGEA4, NY-ESO-1 positive expression was lower than that of MAGEA4, NY-ESO-1 negative expression(P<0.05). MAGEA4 positive expression, lymph node metastasis, TNM stage IIIA and NY-ESO-1 positive expression were risk factors for poor prognosis of NSCLC patients (P<0.05). Conclusion: The positive expression rates of MAGEA4 and NY-ESO-1 in NSCLC tissues are increase, which are relate to lymph node metastasis, TNM stage IIIA, poor differentiationand poor prognosis of NSCLC patients. |
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