| 许丽华,张 允,仇俊兰,张 怀,潘承祺.LncRNA SOCS2-AS1、miR-454-3p在人胃癌组织中的表达及临床意义[J].,2024,(22):4327-4329 |
| LncRNA SOCS2-AS1、miR-454-3p在人胃癌组织中的表达及临床意义 |
| Expression and Clinical Significance of LncRNA SOCS2-AS1 and miR-454-3p in Human Gastric Cancer Tissues |
| 投稿时间：2024-07-02 修订日期：2024-07-30 |
| DOI：10.13241/j.cnki.pmb.2024.22.037 |
| 中文关键词: 胃癌 LncRNA SOCS2-AS1 miR-454-3p 病理特征 预后 |
| 英文关键词: Gastric cancer LncRNA SOCS2-AS1 miR-454-3p Pathological features Prognosis |
| 基金项目:江苏省科技厅社会发展-临床前沿技术项目（BE2018669） |
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| 中文摘要: |
| 摘要 目的：探讨长链非编码核糖核酸（LncRNA）细胞因子信号转导抑制因子2-反义转录本1（SOCS2-AS1）、微小核糖核酸（miRNA）-454-3p在人胃癌组织中的表达及临床意义。方法：选取120例行胃癌根治术患者的胃癌组织和癌旁组织。检测上述组织中LncRNA SOCS2-AS1、miR-454-3p表达。分析LncRNA SOCS2-AS1、miR-454-3p表达与胃癌患者临床病理特征和预后的关系，多因素COX回归分析胃癌患者预后不良的影响因素。结果：胃癌组织中LncRNA SOCS2-AS1、miR-454-3p表达均低于癌旁组织（P＜0.05）。LncRNA SOCS2-AS1、miR-454-3p表达与分化程度、浸润深度、淋巴结转移、TNM分期有关（P＜0.05）。LncRNA SOCS2-AS1低表达组3年总生存率（OS）低于LncRNA SOCS2-AS1高表达组，miR-454-3p低表达组3年OS低于miR-454-3p高表达组（P＜0.05）。发生淋巴结转移、TNM分期Ⅲ期是胃癌患者预后不良的危险因素（P＜0.05），miR-454-3p、LncRNA SOCS2-AS1高表达是胃癌患者预后不良的保护因素（P＜0.05）。结论：胃癌组织中LncRNA SOCS2-AS1、miR-454-3p呈低表达，二者与胃癌患者病理特征及预后不良密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression and clinical significance of long non-coding ribonucleic acids (LncRNA) cytokine signal transduction inhibitor 2-antisense transcript 1 (SOCS2-AS1) and micribonucleic acid (miRNA)-454-3p in human gastric cancer tissues. Methods: The gastric cancer tissues and adjacent tissues of 120 patients undergoing radical gastrectomy were selected. The expression of LncRNA SOCS2-AS1 and miR-454-3p in above-mentioned tissues were detected. After 3 years of follow-up, the relationship between the expression of LncRNA SOCS2-AS1, miR-454-3p and the clinical pathological characteristics and prognosis of gastric cancer patients by analysis, and the influencing factors of poor prognosis in gastric cancer patients were analyzed by multivariate COX regression. Results: The expression of LncRNA SOCS2-AS1 and miR-454-3p in gastric cancer tissues was lower than that in adjacent tissues (P<0.05). The expression of LncRNA SOCS2-AS1 and miR-454-3p was related to the degree of differentiation, depth of invasion, lymph node metastasis and TNM stage (P<0.05). The 3-year overall survival (OS) in LncRNA SOCS2-AS1 low expression group was lower than that in LncRNA SOCS2-AS1 high expression group, and the 3-year OS in miR-454-3p low expression group was lower than that in miR-454-3p high expression group (P<0.05). Lymph node metastasis and TNM stage III were risk factors for poor prognosis in gastric cancer patients (P<0.05). High expression of miR-454-3p and LncRNA SOCS2-AS1 was a protective factor for poor prognosis in gastric cancer patients (P<0.05). Conclusion: The low expression of LncRNA SOCS2-AS1 and miR-454-3p in gastric cancer tissues is closely related to the pathological characteristics and poor prognosis of gastric cancer patients. |
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