| 何 汝,栗凤霞,郝瑞军,王红云,王俊平.米曲菌胰酶片对肝硬化相关消化不良患者肠道菌群、胃肠功能
及血清GLP-1和PYY水平的影响[J].,2024,(22):4317-4319 |
| 米曲菌胰酶片对肝硬化相关消化不良患者肠道菌群、胃肠功能
及血清GLP-1和PYY水平的影响 |
| Effects of Aspergillus Oryzae Pancreatin Tablets on Intestinal Flora, Gastrointestinal Function and Serum GLP-1 and PYY Levelsin Patients with Cirrhosis-Related Dyspepsia |
| 投稿时间：2024-07-02 修订日期：2024-07-30 |
| DOI：10.13241/j.cnki.pmb.2024.22.034 |
| 中文关键词: 米曲菌胰酶片 肝硬化 消化不良 肠道菌群 胃肠功能 胰高糖素样肽-1 酪酪肽 |
| 英文关键词: Aspergillus oryzae pancreatin tablets Cirrhosis Dyspepsia Intestinal flora Gastrointestinal function Glucagon-like peptide-1 Casein peptide |
| 基金项目:山西省医学重点科研项目（2020XM23） |
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| 中文摘要: |
| 摘要 目的：探讨米曲菌胰酶片对肝硬化相关消化不良患者肠道菌群、胃肠功能及血清胰高糖素样肽-1（GLP-1）和酪酪肽（PYY）水平的影响。方法：将我院129例肝硬化相关消化不良患者随机分为对照组（肝硬化常规治疗，n=64）和实验组（在对照组的基础上接受米曲菌胰酶片治疗，n=65）。对比两组消化不良症状积分、肠道菌群指标、胃肠功能指标、血清GLP-1和PYY水平、生活质量变化情况。结果：实验组治疗第4周后消化不良症状积分、肠球菌、肠杆菌数量、GLP-1、PYY水平和NDI评分低于对照组，双歧杆菌、乳酸杆菌数量、胃排空率、胃运动指数、胃收缩频率、肠蠕动频率高于对照组（P＜0.05）。结论：米曲菌胰酶片通过促进肠道菌群平衡、改善胃肠功能、调节血清GLP-1和PYY水平，可减轻肝硬化患者的消化不良症状，改善患者的生活质量。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of aspergillus oryzae pancreatin tablets on intestinal flora, gastrointestinal function and serum glucagon-like peptide-1 (GLP-1) and casein peptide (PYY) levels in patients with cirrhosis-related dyspepsia. Methods: According to the random number table method, 129 patients with liver cirrhosis-related dyspepsia who were treated in our hospital from March 2021 to December 2023 were divided into control group (routine treatment of liver cirrhosis, n=64) and experimental group (treated with aspergillus oryzae trypsin tablets on the basis of control group, n=65). The changes of dyspepsia symptom score, intestinal flora index, gastrointestinal function index, serum GLP-1 and PYY levels and quality of life were compared between two groups. Results: The scores of dyspepsia symptoms, the number of enterococcus, enterobacter, the levels of GLP-1, PYY and NDI score in experimental group were lower than that in control group 4 weeks after treatment, and the number of bifidobacteria, lactobacilli, the gastric emptying rate, gastric motility index, gastric contraction frequency and intestinal peristalsis frequency were higher than that in control group (P<0.05). Conclusion: Aspergillus oryzae pancreatin tablets by promoting the balance of intestinal flora, improving gastrointestinal function and regulating serum GLP-1 and PYY levels, which can alleviate the dyspepsia symptoms of patients with cirrhosis and improve the quality of life of patients. |
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