| 汪佳玲,张静娟,陈舒月,张靖文,王小雨,冯 文.血清睾酮、PON-1、PKM2与子宫内膜癌患者临床病理特征和预后的关系[J].,2024,(22):4308-4310 |
| 血清睾酮、PON-1、PKM2与子宫内膜癌患者临床病理特征和预后的关系 |
| Relationship between Serum Testosterone, PON-1, PKM2 and Clinicopathological Features and Prognosis of Endometrial Cancer Patients |
| 投稿时间：2024-05-24 修订日期：2024-06-20 |
| DOI：10.13241/j.cnki.pmb.2024.22.031 |
| 中文关键词: 子宫内膜癌 睾酮 对氧磷酶 -1 丙酮酸激酶 M2 临床病理特征 预后 |
| 英文关键词: Endometrial carcinoma Testosterone Paraoxonase-1 Pyruvate kinase M2 Clinicopathological features Prognosis |
| 基金项目:江苏省妇幼健康科研项目（F201669） |
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| 中文摘要: |
| 摘要 目的：探讨血清睾酮（T）、对氧磷酶-1（PON-1）、丙酮酸激酶M2（PKM2）与子宫内膜癌（EC）患者临床病理特征和预后的关系。方法：收集120例EC患者的临床资料，分析血清T、PON-1、PKM2与EC患者临床病理特征的关系；绘制K-M生存曲线分析3年总生存率（OS）；Cox比例风险模型分析影响因素。结果：肌层浸润≥1/2、有淋巴结转移、腹腔积液亦或是肿瘤细胞冲洗液阳性、国际妇产科联盟（FIGO）分期为Ⅲ-Ⅳ期的血清T及PKM2水平较肌层浸润＜1/2、无淋巴结转移、腹腔积液亦或是肿瘤细胞冲洗液阴性、FIGO分期为Ⅰ-Ⅱ期更高，而PON-1则相对更低（P＜0.05）。EC患者血清T及PKM2低水平，PON-1高水平的3年OS较血清T及PKM2高水平，PON-1低水平更高（P＜0.05）。Cox比例风险模型分析显示，腹腔积液亦或是肿瘤细胞冲洗液阳性、血清T高水平、PON-1低水平及PKM2高水平是EC患者不良预后的危险因素。结论：血清T、PKM2高水平，PON-1低水平与EC患者的肌层浸润、淋巴结转移、腹腔积液亦或是肿瘤细胞冲洗液阳性、FIGO分期III-IV期及不良预后有关，EC患者不良预后的危险因素包括腹腔积液亦或是肿瘤细胞冲洗液阳性、血清T高水平、PON-1低水平及PKM2高水平。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum testosterone (T), paraoxonase-1 (PON-1), pyruvate kinase M2 (PKM2) and clinicopathological features and prognosis of endometrial carcinoma (EC) patients. Methods: The clinical data of 120 EC patients were collected. The relationship between serum T, PON-1, PKM2 and clinicopathological features of EC patients was analyzed. The 3-year overall survival (OS) was analyzed by drawn K-M survival curve. The prognostic factors of EC patients were analyzed by Cox proportional hazard model. Results: The levels of serum T and PKM2 in patients with myometrial invasion≥1/2, lymph node metastasis, ascites or tumor cell flushing fluid positive and International Federation of Gynecology and Obstetrics (FIGO) stage III-IV were higher than those in patients with myometrial invasion<1/2, no lymph node metastasis, ascites or tumor cell flushing fluid negative and FIGO stage I-II, while PON-1 was relatively lower (P<0.05). The 3-year OS of EC patients with high PON-1 level was higher than that of EC patients with high serum T and PKM2 levels, and the low level of PON-1 was higher (P<0.05). Cox proportional hazard model analysis showed that, ascites or tumor cell flushing fluid positive, high serum T level, low PON-1 level and high PKM2 level were risk factors for poor prognosis in EC patients. Conclusion: High levels of serum T, PKM2, and low levels of PON-1 are associate with myometrial invasion, lymph node metastasis, ascites or tumor cell flushing fluid positive, FIGO stage III-IV and poor prognosis in EC patients, risk factors for poor prognosis in EC patients include ascites or tumor cell flushing fluid positive, high levels of serum T, low levels of PON-1 and high levels of PKM2. |
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