| 刘雪龙,刘 展,王艮卫,陶胜忠,尹梦磊.脑脊液TREM-1、MCP-1与动脉瘤性蛛网膜下腔出血患者手术
治疗转归的关系[J].,2024,(22):4305-4307 |
| 脑脊液TREM-1、MCP-1与动脉瘤性蛛网膜下腔出血患者手术
治疗转归的关系 |
| Relationship between TREM-1 and MCP-1 in Cerebrospinal Fluidand the Outcome of Surgical Treatment in Patientswith Aneurysmal Subarachnoid Hemorrhage |
| 投稿时间：2024-06-05 修订日期：2024-07-07 |
| DOI：10.13241/j.cnki.pmb.2024.22.030 |
| 中文关键词: 动脉瘤性蛛网膜下腔出血 髓样细胞触发受体-1 单核细胞趋化蛋白-1 术后转归 |
| 英文关键词: Aneurysmal subarachnoid hemorrhage Triggering receptor expressed on myeloid cells-1 Monocyte chemotactic protein-1 Postoperative outcome |
| 基金项目:河南省医学科技攻关计划项目（RKX202202032） |
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| 中文摘要: |
| 摘要 目的：探讨脑脊液髓样细胞触发受体-1（TREM-1）、单核细胞趋化蛋白-1（MCP-1）与动脉瘤性蛛网膜下腔出血（aSAH）患者手术治疗转归的关系。方法：选择294例aSAH患者，术前检测脑脊液TREM-1、MCP-1水平。出院后随访3个月，采用改良Rankin量表（mRS）评估患者预后，并据此将患者分为转归不良组（103例）和转归良好组（191例）。多因素Logistic回归分析影响aSAH术后转归不良的因素。结果：转归不良组脑脊液TREM-1、MCP-1水平均高于转归良好组（P＜0.05）。Hunt-Hess分级Ⅲ～Ⅳ级、并发迟发性脑缺血、TREM-1升高、MCP-1升高是aSAH术后转归不良的危险因素（P＜0.05）。结论：aSAH术后转归不良患者血清TREM-1、MCP-1水平升高，是aSAH术后转归不良的危险因素。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between triggering receptor expressed on myeloid cells-1 (TREM-1) and monocyte chemoattractant protein-1 (MCP-1) in cerebrospinal fluid and the outcome of surgical treatment in patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods: 294 patients with aSAH were selected, the levels of TREM-1 and MCP-1 in cerebrospinal fluid were detected before operation. 3 months after discharge, patient outcomes were assessed using the modified Rankin scale (mRS), and patients were divided into poor outcome group (103 cases) and good outcome group (191 cases) according to this. The factors affecting the poor outcome after aSAH were analyzed by multivariate logistic regression analysis. Results: The levels of TREM-1 and MCP-1 in cerebrospinal fluid in poor outcome group were higher than those in good outcome group(P<0.05). Hunt-Hess grade III~IV, delayed cerebral ischemia, increased TREM-1 and MCP-1 were risk factors for poor outcome after aSAH(P<0.05). Conclusion: The increase of serum TREM-1 and MCP-1 levels in patients with poor outcome after aSAH are risk factor for poor outcome after aSAH. |
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