| 刘丽娟,康 涛,王卫婵,卫婧雅,杜 芳.血清BDNF、IGF-1及CysC水平与帕金森病患者
自主神经功能障碍的关系研究[J].,2024,(22):4268-4270 |
| 血清BDNF、IGF-1及CysC水平与帕金森病患者
自主神经功能障碍的关系研究 |
| Study on the Relationship between Serum BDNF, IGF-1 and CysC Levels and Autonomic Nerve Dysfunction in Patients with Parkinson's Disease |
| 投稿时间：2024-05-24 修订日期：2024-06-20 |
| DOI：10.13241/j.cnki.pmb.2024.22.019 |
| 中文关键词: 脑源性神经营养因子 胰岛素样生长因子-1 胱抑素C 帕金森病 自主神经功能障碍 |
| 英文关键词: Brain-derived neurotrophic factor Insulin-like growth factor Cystatin C Parkinson's disease Autonomic nerve dysfunction |
| 基金项目:陕西省自然科学基础研究计划项目（2020JM-338） |
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| 中文摘要: |
| 摘要 目的：研究血清脑源性神经营养因子（BDNF）、胰岛素样生长因子（IGF）-1及胱抑素C（CysC）水平与帕金森病（PD）患者自主神经功能障碍的关系。方法：188例PD患者根据是否发生自主神经功能障碍分为自主神经功能障碍组（n=63）、非自主神经功能障碍组（n=125）。另选取健康志愿者140例为对照组。比较三组BDNF、IGF-1水平。采用多因素Logistic回归分析影响因素。结果：对照组、非自主神经功能障碍组、自主神经功能障碍组BDNF、IGF-1水平依次下降，CysC水平依次升高（P＜0.05）。血清BDNF、IGF-1低水平、血清CysC高水平、SSR异常、H-Y分期2.5~4期是PD患者自主神经功能障碍的危险因素（P＜0.05）。结论：血清BDNF、IGF-1低水平及CysC高水平促进PD患者自主神经功能障碍的发生发展。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between serum brain-derived neurotrophic factor (BDNF), insulin-like growth factor (IGF)-1 and cystatin C (CysC) levels and autonomic nerve dysfunction in patients with Parkinson's disease (PD). Methods: 188 PD patients were divided into autonomic nerve dysfunction group (n=63) and non-autonomic nerve dysfunction group (n=125) according to the occurrence of autonomic nerve dysfunction, and 140 healthy volunteers were selected as the control group. the levels of BDNF and IGF-1 among three groups were compared. The influencing factors was analyzed by multivariate Logistic regression analysis. Results: The BDNF, IGF-1 levels in control group, non-autonomic nerve dysfunction group and autonomic nerve dysfunction group decreased in turn, and the CysC level increased in turn(P<0.05). Low serum BDNF, IGF-1 levels, high serum CysC level, abnormal SSR, and H-Y stage 2.5~4 were risk factors for autonomic dysfunction in PD patients(P<0.05). Conclusion: The low serum BDNF, IGF-1 levels and high CysC level promote the occurrence and development of autonomic nerve dysfunction in PD patients. |
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