| 刘亚伟,马俊福,谷慧敏,杨双庆,李玉洁,李锦锦.加味芍甘附子汤联合温和灸对寒湿痹阻型活动期类风湿关节炎患者
免疫功能和血清IL-1?茁、IL-6、IL-18的影响[J].,2024,(22):4247-4249 |
| 加味芍甘附子汤联合温和灸对寒湿痹阻型活动期类风湿关节炎患者
免疫功能和血清IL-1?茁、IL-6、IL-18的影响 |
| Effects of Jiawei Shaogan Fuzi Decoction Combined with Mild Moxibustion on Immune Function and Serum IL-1?茁, IL-6 and IL-18 in Patients with Active Rheumatoid Arthritis of Cold-Dampness Obstruction Type |
| 投稿时间：2024-05-16 修订日期：2024-06-10 |
| DOI：10.13241/j.cnki.pmb.2024.22.012 |
| 中文关键词: 加味芍甘附子汤 活动期 温和灸 寒湿痹阻型 免疫功能 IL-1?茁 IL-6 IL-18 类风湿关节炎 |
| 英文关键词: Jiawei shaogan fuzi decoction Active stage Mild moxibustion Cold-dampness obstruction type Immune function IL-1?茁 IL-6 IL-18 Rheumatoid arthritis |
| 基金项目:河南省中医药科学研究专项课题（2022ZY1062）；国家自然科学基金青年项目（81804050）；
河南省中医药学科拔尖人才资助项目（{豫卫中医〔2021〕15号}） |
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| 中文摘要: |
| 摘要 目的：观察加味芍甘附子汤、温和灸联合治疗寒湿痹阻型活动期类风湿关节炎（RA）患者，对免疫功能和血清白细胞介素（IL）-1α、IL-6、IL-18的影响。方法：选取142例活动期RA患者（寒湿痹阻型）按随机数字表法分为对照组（温和灸治疗，n=71）和b联合组（加味芍甘附子汤联合温和灸治疗，n=71）。对比两组疗效、实验室指标、免疫功能和血清炎症因子。结果：与对照组相比，联合组的临床总有效率明显升高（P<0.05）。与对照组治疗后相比，联合组的类风湿因子（RF）、血沉（ESR）、C反应蛋白（CRP）、免疫球蛋白G（IgG）、免疫球蛋白G（IgA）、免疫球蛋白M（IgM）、IL-1α、IL-6、IL-18更低（P<0.05）。结论：加味芍甘附子汤联合温和灸治疗寒湿痹阻型活动期RA患者，可提高临床治疗效果，调节免疫功能和抑制血清IL-1?茁、IL-6、IL-18水平。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the combined treatment of jiawei shaogan fuzi decoction and mild moxibustion in patients with active rheumatoid arthritis (RA) of cold-dampness obstruction type, the effects on immune function and serum interleukin (IL)-1α, IL-6, IL-18. Methods: 142 patients with active RA (cold-dampness obstruction type) were divided into control group (mild moxibustion treatment, n=71) and combine group (Jiawei Shaogan Fuzi Decoction combine with mild moxibustion treatment, n=71) according to the random number table method. The efficacy, laboratory indexes, immune function and serum inflammatory factors were compared between two groups. Results: Compared with control group, the total clinical effective rate in combine group was significantly higher (P<0.05). Compared with control group after treatment, rheumatoid factor (RF), erythrocyte sedimentation rate(ESR), C-reactive protein (CRP), immunoglobulin G(IgG), immunoglobulin G(IgA), immunoglobulin M(IgM), IL-1α, IL-6 and IL-18 in combine group were lower (P<0.05). Conclusion: Jiawei shaogan fuzi decoction combined with mild moxibustion can improve clinical treatment effect, regulate immune function and inhibit serum IL-1α, IL-6 and IL-18 levels in patients with active RA of cold-dampness obstruction type. |
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