| 谢子莎,陶 黎,杨春梅,张 凤,樊 琦,李 花.脑梗死患者阿替普酶静脉溶栓治疗前后血清抗磷脂抗体、同型半胱氨酸及载脂蛋白变化及预后影响因素分析[J].,2024,(21):4157-4160 |
| 脑梗死患者阿替普酶静脉溶栓治疗前后血清抗磷脂抗体、同型半胱氨酸及载脂蛋白变化及预后影响因素分析 |
| Analysis of Changes in Serum Antiphospholipid Antibodies, Homocysteine, and Apolipoprotein Levels and Prognostic Factors in Patients with Cerebral Infarction before and after Intravenous Thrombolysis with Ateplase |
| 投稿时间：2024-04-22 修订日期：2024-05-16 |
| DOI：10.13241/j.cnki.pmb.2024.21.032 |
| 中文关键词: 脑梗死 抗磷脂抗体 同型半胱氨酸 载脂蛋白 |
| 英文关键词: Cerebral infarction Anti phospholipid antibodies Homocysteine Apolipoprotein |
| 基金项目:国家卫生健康委医药卫生科技研究中心项目（WKZX2023G70226） |
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| 中文摘要: |
| 摘要 目的：探讨脑梗死患者阿替普酶静脉溶栓治疗前后血清抗磷脂抗体（APA）、同型半胱氨酸（Hcy）、载脂蛋白（apo）-C3、apo-B变化及预后影响因素分析。方法：2021年1月至2023年1月期间在我院接受治疗的80例脑梗死患者，比较各组指标以及分析预后影响因素。结果：治疗后Hcy、apoC3、apo-B水平低于治疗前（P＜0.05）；预后良好组与预后不良组患者年龄、溶栓前神经功能缺损量表（Neurological Deficiency Scale, NIHSS）评分、起病到溶栓时间、合并高血压、合并糖尿病、合并脑白质病变、合并脑萎缩、合并脑水肿情况、APA阳性率、Hcy、apoC3、apo-B水平对比差异显著（P＜0.05）；年龄、溶栓前NIHSS评分、合并脑水肿、APA阳性率、Hcy、apoC3、apo-B为预后独立影响因素（P＜0.05）。结论：阿替普酶溶栓治疗前后同型半胱氨酸及载脂蛋白明显改变，且年龄、溶栓前NIHSS评分、合并脑水肿、APA阳性率、Hcy、apoC3、apo-B是影响脑梗死的预后独立危险因素。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the changes of serum antiphospholipid antibody (APA), homocysteine (Hcy), apolipoprotein (apo) -C3, apo-B and the influencing factors before and after intravenous thrombolytic therapy in patients with cerebral infarction. Methods: 80 patients with cerebral infarction treated from January 2021 to January 2023 compared the indicators and analyzed the prognostic factors. Results: The levels of Hcy, apoC3, and apo-B were lower than those before treatment (P<0.05); Patient Age and pre-thrombolysis Neurologic Defects Scale (Neurological Deficiency Scale, NIHSS) score, time from onset to thrombolysis, hypertension, diabetes, white matter lesions, cerebral atrophy, cerebral edema, APA positive rate, Hcy, apoC 3, and apo-B levels varied significantly(P<0.05); Age, pre-thrombolysis NIHSS score, combined cerebral edema, APA positive rate, Hcy, apoC3, and apo-B were independent prognostic factors(P<0.05). Conclusion: Homocysteine and apolipoprotein were significantly changed before and after alteplase thrombolytic therapy, and age, NIHSS score before thrombolysis, combined cerebral edema, APA positive rate, Hcy, apoC 3 and apo-B were independent prognostic risk factors for cerebral infarction. |
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