| 顾海迪,杜玲玉,杨 军,李 辰,何贞月,谭 洁,王晨洁.非小细胞肺癌组织CXCL1、CXCL2表达与上皮间质转化及预后的关系研究[J].,2024,(21):4144-4147 |
| 非小细胞肺癌组织CXCL1、CXCL2表达与上皮间质转化及预后的关系研究 |
| Study on the Relationship between CXCL1, CXCL2 Expression and Epithelial Mesenchymal Transition and Prognosis in Non-Small Cell Lung Cancer Tissues |
| 投稿时间：2024-05-22 修订日期：2024-06-17 |
| DOI：10.13241/j.cnki.pmb.2024.21.028 |
| 中文关键词: 非小细胞肺癌 C-X-C基序趋化因子配体1 C-X-C基序趋化因子配体2 上皮间质转化 预后 |
| 英文关键词: Non-small cell lung cancer C-X-C motif chemokine ligand 1 C-X-C motif chemokine ligand 2 Epithelial mesenchymal transition Prognosis |
| 基金项目:江苏省卫健委医学科研面上项目（M2020043）；苏州市科技计划项目（SYS2020167） |
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| 中文摘要: |
| 摘要 目的：探讨非小细胞肺癌（NSCLC）组织C-X-C基序趋化因子配体（CXCL）1、CXCL2表达与上皮间质转化（EMT）及预后的关系。方法：选取行手术切除的NSCLC患者241例，检测NSCLC组织与癌旁组织（距NSCLC组织＞3 cm）中CXCL1、CXCL2和EMT相关蛋白[波形蛋白（Vimentin）、蜗牛家族转录抑制因子1（SNAI1）、E-钙黏蛋白（E-cadherin）、N-钙黏蛋白（N-cadherin）]阳性表达率。比较NSCLC组织中CXCL1、CXCL2阳性表达在不同临床病理特征患者中的差异。随访3年，记录NSCLC患者总生存（OS）率，分析CXCL1、CXCL2阳性/阴性表达对NSCLC患者预后的影响。结果：与癌旁组织比较，NSCLC组织CXCL1、CXCL2、Vimentin、SNAI1、N-cadherin阳性表达率升高，E-cadherin阳性表达率降低（P＜0.05）。NSCLC组织CXCL1、CXCL2表达与TNM分期、肿瘤直径、分化程度和淋巴结转移有关（P＜0.05）。随访3年，241例NSCLC患者3年OS率为56.02%（135/241）。NSCLC患者中CXCL1、CXCL2阳性表达者3年OS率低于CXCL1、CXCL2阴性表达者（P＜0.05）。结论：NSCLC组织CXCL1、CXCL2高表达，且与TNM分期、肿瘤直径、分化程度、淋巴结转移、EMT和预后有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the expression of C-X-C motif chemokine ligand (CXCL) 1 and CXCL2 in non-small cell lung cancer (NSCLC) tissues and epithelial mesenchymal transition (EMT) and prognosis. Methods: 241 NSCLC patients were selected, the positive expression rates of CXCL1, CXCL2 and EMT-related proteins [Vimentin (Vimentin), snail family transcription inhibitor 1 (SNAI1), E-cadherin (E-cadherin), and N-cadherin (N-cadherin)] in NSCLC tissues and adjacent tissues (>3 cm from NSCLC tissue) were detected by immunohistochemistry. The correlation between CXCL1, CXCL2 expression and expression of EMT-related proteins in NSCLC tissues were analyzed. To compare the difference of CXCL1 and CXCL2 positive expression in NSCLC tissues in patients with different clinicopathological features. 3 years after follow-up, the 3-year overall survival (OS) rate was recorded. Results: Compared with adjacent tissues, the positive expression rates of CXCL1, CXCL2, Vimentin, SNAI1 and N-cadherin in NSCLC tissues were increased, and the positive expression rate of E-cadherin was decreased (P<0.05). The expression of CXCL1 and CXCL2 in NSCLC tissues were related to TNM stage, tumor diameter, degree of differentiation and lymph node metastasis (P<0.05). Followed-up for 3 years, the 3-year OS rate of 241 NSCLC patients was 56.02 % (135/241). The 3-year OS rate of CXCL1 and CXCL2 positive expression in NSCLC patients was lower than that of CXCL1 and CXCL2 negative expression.(P<0.05). The independent risk factors for death in NSCLC patients were TNM stage IIIA, tumor diameter≥3 cm, poor differentiation, CXCL1 positive, lymph node metastasis and CXCL2 positive (P<0.05). Conclusion: The high expression of CXCL1 and CXCL2 in NSCLC tissues are related to TNM stage, tumor diameter, degree of differentiation, lymph node metastasis, EMT and prognosis, which may become a new target for the diagnosis and treatment of NSCLC. |
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