| 杨海芳,薛姣姣,王 鹏,高向向,刘 杰.彩色多普勒超声成像结合乳腺钼靶、EGF/EGFR、MIC-1对乳腺浸润性导管癌的评估价值[J].,2024,(21):4140-4143 |
| 彩色多普勒超声成像结合乳腺钼靶、EGF/EGFR、MIC-1对乳腺浸润性导管癌的评估价值 |
| Value of Color Doppler Ultrasound Imaging Combined with Mammography, EGF/EGFR and MIC-1 in the Evaluation of Breast Invasive Ductal Carcinoma |
| 投稿时间：2024-05-11 修订日期：2024-06-04 |
| DOI：10.13241/j.cnki.pmb.2024.21.027 |
| 中文关键词: 乳腺浸润性导管癌 彩色多普勒超声成像 乳腺钼靶 EGF EGFR MIC-1 评估价值 |
| 英文关键词: Breast invasive ductal carcinoma Color doppler ultrasound imaging Mammography EGF EGFR MIC-1 Evaluation value |
| 基金项目:陕西省重点研发计划项目（2021SF-007） |
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| 中文摘要: |
| 摘要 目的：探讨彩色多普勒超声成像结合乳腺钼靶、表皮生长因子（EGF）及其受体（EGFR）、巨噬细胞抑制因子-1（MIC-1）对乳腺浸润性导管癌的评估价值。方法：乳腺浸润性导管癌71例作为研究组，同期71例乳腺良性结节患者作为对照组。两组均接受彩色多普勒超声成像、乳腺钼靶检查及EGF/EGFR、MIC-1检测，比较两组超声特征、钼靶特征及EGF/EGFR、MIC-1水平差异；以非条件Logistic全模回归，构建预测模型探讨彩色多普勒超声成像结合乳腺钼靶、EGF/EGFR、MIC-1对乳腺浸润性导管癌的评估价值。结果：研究组低回声区不规则、边界模糊、有毛刺与分叶征、微钙化、血流信号丰富、腋窝淋巴结肿大、纵横比＞1等超声特征占比明显高于对照组（均P＜0.05）。研究组形态不规则、边界模糊、毛刺与分叶征、微钙化、粗大血管影、腋窝淋巴结肿大、局部致密性浸润等钼靶特征占比明显高于对照组（均P＜0.05）。研究组EGF/EGFR、MIC-1水平明显高于对照组（均P＜0.05）。受试者工作特征曲线（ROC）分析结果显示，超声特征评估模型、钼靶特征评估模型、EGF/EGFR、MIC-1评估模型对乳腺浸润性导管癌均具有一定诊断价值，而联合应用模型的诊断效能明显高于各模型单独应用（均P＜0.05）。结论：彩色多普勒超声成像结合乳腺钼靶、EGF/EGFR、MIC-1对乳腺浸润性导管癌具有较高的评估价值。 |
| 英文摘要: |
| ABSTRACT Objective: To evaluate the value of color doppler ultrasound imaging combined with mammography, epidermal growth factor (EGF) and its receptor (EGFR), and macrophage inhibitory cytokine-1 (MIC-1) in breast invasive ductal carcinoma. Methods: 71 cases of breast invasive ductal carcinoma as the study group, and 71 patients with benign breast nodules as the control group. Both groups received color Doppler ultrasound imaging, mammography, EGF/EGFR and MIC-1 detection. The differences of ultrasound features, mammography features, EGF/EGFR and MIC-1 levels between the two groups were compared. The predictive model was constructed by unconditional Logistic regression to explore the value of color Doppler ultrasound imaging combined with mammography, EGF/EGFR and MIC-1 in the evaluation of breast invasive ductal carcinoma. Results: The proportion of ultrasonic features such as irregular low echo area, blurred boundary, burr and lobulation sign, microcalcification, rich blood flow signal, axillary lymph node enlargement and aspect ratio>1 in the study group was significantly higher than that in the control group (all P<0.05). The proportion of mammography features such as irregular shape, blurred boundary, burr and lobulation sign, microcalcification, coarse vascular shadow, axillary lymph node enlargement and local dense infiltration in the study group was significantly higher than that in the control group (all P<0.05). The levels of EGF/EGFR and MIC-1 in the study group were significantly higher than those in the control group (all P<0.05). The receiver operating characteristic curve (ROC) analysis showed that the ultrasound feature evaluation model, molybdenum target feature evaluation model, EGF / EGFR and MIC-1 evaluation model had certain diagnostic value for breast invasive ductal carcinoma, and the diagnostic efficacy of the combined application model was significantly higher than that of each model alone(all P<0.05). Conclusion: Color doppler ultrasound imaging combined with mammography, EGF/EGFR and MIC-1 has a high evaluation value for breast invasive ductal carcinoma. |
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