| 冉清智,李傲霜,陈恒文,姚 博,马静卓,张永康.心肌梗死、心力衰竭和心房颤动对脑血管意外的影响：一项孟德尔随机化研究[J].,2024,(21):4064-4070 |
| 心肌梗死、心力衰竭和心房颤动对脑血管意外的影响：一项孟德尔随机化研究 |
| Effect of Myocardial Infarction, Heart Failure and Atrial Fibrillation on Cerebrovascular Accidents: a Mendelian Randomized Study |
| 投稿时间：2024-05-13 修订日期：2024-05-30 |
| DOI：10.13241/j.cnki.pmb.2024.21.011 |
| 中文关键词: 心血管疾病 脑血管意外 孟德尔随机化（MR） 心肌梗死 心力衰竭 心房颤动 全基因组关联研究（GWAS） |
| 英文关键词: Cardiovascular disease Cerebrovascular accident Mendelian randomization (MR) Myocardial infarction Heart failure Atrial fibrillation Genome-wide association study (GWAS) |
| 基金项目:国家自然科学基金项目（82074396）；中国中医科学院科技创新工程重大攻关项目（CI2021A05011）；中国中医科学院科技创新工程创新团队项目（CI2021B017-05）；高水平中医医院建设项目（CZ40909；CZ30977）；新疆维吾尔自治区区域协同创新专项（上海合作组织科技伙伴计划及国际科技合作计划）项目；民族药海外注册与临床国际科技合作与服务研究（2022E01001） |
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| 中文摘要: |
| 摘要 目的：传统研究从观察和实证的角度表明，心血管疾病中的心肌梗死（MI）、心力衰竭（HF）、心房颤动（AF）和脑血管意外（CVA）之间存在密切联系，但上述心血管疾病与脑血管意外之间的因果关系尚未得到证实。因此，我们进行了一项孟德尔随机化（MR）研究，以探讨 MI、HF、AF 与 CVA 之间的因果关系。方法：采用逆方差加权法、加权中位数法和 MR Egger 法进行 MR 估计。在敏感性分析中使用了 Cochran's Q 检验、MR-Egger 截距检验、MR-PRESSO、MR Steiger 检验、leave-one-out 分析和漏斗图。此外，还整理了MI、HF、AF的相关暴露 SNPs。结果：MI、HF和AF分别与CVA进行孟德尔随机化，MR-Egger结果显示，MI与CVA风险相关（MI vs. CVA，P<0.05，OR（95% CI）：420.722（3.45-51171.12））；HF与CVA风险相关（HF vs. CVA，OR（95% CI）：1.324（1.14-1.53））；AF与CVA风险相关（AF vs. CVA，P<0.05，OR（95% CI）：58671.12-149821.35）。结论：这项 MR 研究初步表明，MI、HF 和AF与 CVA 的因果关系是可靠的。 |
| 英文摘要: |
| ABSTRACT Objective: Traditional studies have shown a close association between myocardial infarction (MI), heart failure (HF), atrial fibrillation (AF) and cerebrovascular accidents (CVA) among cardiovascular diseases from both observational and empirical perspectives, but a causal relationship between the above cardiovascular diseases and CVA has not yet been confirmed. Therefore, we conducted a Mendelian randomization (MR) study to investigate the causal relationship between MI, HF, AF and CVA. Methods: MR estimation was performed using the inverse variance weighting method, weighted median method, and MR Egger method. Cochran's Q test, MR-Egger intercept test, MR-PRESSO, MR Steiger test, leave-one-out analysis, and funnel plot were used in sensitivity analysis. In addition, exposure SNPs associated with myocardial infarction, AF, and AF were collated. Results: MI, HF, and AF were Mendelian randomized to CVA separately, and MR-Egger results showed that MI was associated with the risk of CVA (MI vs. CVA, P<0.05, OR (95% CI): 420.722 (3.45 to 51171.12)); HF was associated with the risk of CVA (HF vs. CVA, OR (95% CI): 1.324 (1.14 to 1.53)); AF was associated with the risk of CVA (AF vs. CVA, P<0.05, OR (95% CI): 58671.12). Conclusion: This MR study provides preliminary evidence that the causal association of MI, HF and AF with CVA is reliable. |
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