| 吴文婧,李淑洁,孙晓敏,张洪科,尹倩雯,关文芳.胃腺癌组织CMTM3、CMTM6检测的临床价值研究[J].,2024,(20):3971-3973 |
| 胃腺癌组织CMTM3、CMTM6检测的临床价值研究 |
| Clinical Value of Detection of CMTM3 and CMTM6in Gastric Adenocarcinoma |
| 投稿时间：2024-04-18 修订日期：2024-05-10 |
| DOI：10.13241/j.cnki.pmb.2024.20.047 |
| 中文关键词: 胃腺癌 CMTM3 CMTM6 临床病理特征 预后 |
| 英文关键词: Gastric adenocarcinoma CMTM3 CMTM6 Clinicopathological features Prognosis |
| 基金项目:陕西省自然科学基础研究计划(2023-JC-YB-666) |
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| 中文摘要: |
| 摘要 目的：探讨胃腺癌组织趋化素样因子超家族（CMTM）3、CMTM6检测的临床价值。方法：选择我院收治的155例胃腺癌患者，检测术中癌组织和癌旁组织的CMTM3、CMTM6表达。随访3年。分析CMTM3、CMTM6表达与胃腺癌患者临床病理特征的关系和3年总生存期（OS）。多因素COX回归分析影响胃腺癌患者预后的因素。结果：与癌旁组织相比，癌组织CMTM3阳性表达率更低，CMTM6阳性表达率更高（P＜0.05）。CMTM3、CMTM6阳性表达与胃腺癌分化程度、TNM分期、淋巴结转移有关（P＜0.05）。CMTM3、CMTM6阳性表达胃腺癌患者3年OS率分别低于CMTM3、CMTM6阴性表达胃腺癌患者（P＜0.05）。胃腺癌患者预后不良的危险因素包括TNM分期Ⅲ期、CMTM6阳性表达、淋巴结转移（P＜0.05），保护因素则是CMTM3阳性表达（P＜0.05）。结论：胃腺癌组织中CMTM3阳性表达率降低，CMTM6阳性表达率升高，与胃腺癌低分化、TNM分期Ⅲ期、淋巴结转移和低OS有关。 |
| 英文摘要: |
| ABSTRACT Objective: To evaluate the clinical value of detection of chemotin-like factor superfamily (CMTM)3 and CMTM6 in gastric adenocarcinoma. Methods: 155 gastric adenocarcinoma patients who underwent surgical treatment in our hospital were selected,, and the expression of CMTM3 and CMTM6 in the cancerous and adjacent tissues during surgery was detected. Followed up for 3 years.The relationship between the expression of CMTM3 and CMTM6 and the clinicopathological features and the 3-year overall survival (OS) of gastric adenocarcinoma patients was analyzed. The factors affecting the prognosis of gastric adenocarcinoma patients were analyzed by multivariate COX regression analysis. Results: Compared with adjacent tissues, the positive expression rate of CMTM3 was lower and the positive expression rate of CMTM6 was higher in cancer tissues(P<0.05), and the positive expression rate of CMTM6 was higher than that in adjacent tissues (P<0.05). The positive expression of CMTM3 and CMTM6 was related to the degree of differentiation, TNM stage and lymph node metastasis of gastric adenocarcinoma (P<0.05). The 3-year OS rate of CMTM3, CMTM6 positive expression gastric adenocarcinoma patients was lower than that of CMTM3, CMTM6 negative expression gastric adenocarcinoma patients (P<0.05). The risk factors for poor prognosis in gastric adenocarcinoma patients include TNM stage III, positive expression of CMTM6, and lymph node metastasis (P<0.05), while the protective factor is positive expression of CMTM3 (P<0.05). Conclusion: The positive expression rate of CMTM3 in gastric adenocarcinoma tissues is decrease, and the positive expression rate of CMTM6 is increase, which are relate to poor differentiation, TNM stage III, lymph node metastasis and low OS of gastric adenocarcinoma. |
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