| 张 祎,徐 倩,仝晓宁,张 晶,王文静.细菌性血流感染所致脓毒症患者中性粒细胞CD64指数
联合血清APOM、HMGB1对预后的评估价值[J].,2024,(20):3967-3970 |
| 细菌性血流感染所致脓毒症患者中性粒细胞CD64指数
联合血清APOM、HMGB1对预后的评估价值 |
| Evaluation Value of Prognosis of Neutrophil CD64 IndexCombined with Serum APOM and HMGB1 in Patientswith Sepsis Caused by Bacterial Bloodstream Infection |
| 投稿时间：2024-05-05 修订日期：2024-05-26 |
| DOI：10.13241/j.cnki.pmb.2024.20.046 |
| 中文关键词: 中性粒细胞CD64指数 载脂蛋白M 高迁移率族蛋白B1 细菌性血流感染 脓毒症 预后 |
| 英文关键词: Neutrophil CD64 index Apolipoprotein M High mobility group protein B1 Bacterial bloodstream infection Sepsis Prognosis |
| 基金项目:陕西省自然科学基础研究计划青年项目（2023-JC-QN-0898） |
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| 中文摘要: |
| 摘要 目的：研究细菌性血流感染所致脓毒症患者中性粒细胞CD64指数联合血清载脂蛋白M（APOM）、高迁移率族蛋白B1（HMGB1）对预后的评估价值。方法：251例细菌性血流感染所致脓毒症患者，根据入院28 d是否出现了病死分为存活组和病死组。采用Logistic回归模型分析入院28 d病死的影响因素，采用受试者工作特征（ROC）曲线分析CD64指数、血清APOM、HMGB1与常规感染指标预测患者入院28 d病死的价值。结果：与存活组比较，病死组中性粒细胞CD64指数、HMGB1显著升高，血清APOM显著降低（P＜0.05）。APACHEⅡ评分高、降钙素原高、中性粒细胞CD64指数高、C反应蛋白高、HMGB1高、APOM低是细菌性血流感染所致脓毒症患者入院28 d病死的危险因素（P＜0.05）。ROC曲线显示，降钙素原、C反应蛋白、中性粒细胞CD64指数、APOM、HMGB1联合预测细菌性血流感染所致脓毒症患者入院28 d病死风险的曲线下面积（AUC）为0.917，大于单项指标预测。结论：中性粒细胞CD64指数、HMGB1升高及APOM降低与细菌性血流感染所致脓毒症患者入院28 d病死风险相关，且联合降钙素原、C反应蛋白有较高的预测价值。 |
| 英文摘要: |
| ABSTRACT Objective: To study the evaluation value of prognosis of neutrophil CD64 index combined with serum apolipoprotein M (APOM) and high mobility group protein B1 (HMGB1) in patients with sepsis caused by bacterial bloodstream infection. Methods: 251 patients with sepsis caused by bacterial bloodstream infection were divided into survival group and death group according to whether they experienced mortality after 28 days of admission. The influencing factors of 28 d mortality were analyzed by Logistic regression model, the value of CD64 index, serum APOM, HMGB1 and conventional infection indicators in predicting 28 d mortality in patients with sepsis caused by bacterial bloodstream infection were analyzed by receiver operating characteristic(ROC) curve. Results: Compared with survival group, the neutrophil CD64 index and HMGB1 in death group were significantly increased, and the serum APOM was significantly decreased (P<0.05). High APACHEII score, high procalcitonin, high neutrophil CD64 index, high C-reactive protein, high HMGB1, and low APOM were risk factors for 28 d mortality in patients with sepsis caused by bacterial bloodstream infection (P<0.05). ROC curve showed that, the area under the curve (AUC) of procalcitonin, C-reactive protein, neutrophil CD64 index, APOM and HMGB1 in predicting the 28 d mortality risk of sepsis patients caused by bacterial bloodstream infection was 0.917, which was greater than that predicted by single index. Conclusion: The increase of neutrophil CD64 index, HMGB1 and the decrease of APOM are related to the risk of 28 d mortality in patients with sepsis caused by bacterial bloodstream infection, and combined with procalcitonin and C-reactive protein has a high predictive value. |
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