| 白国艳,彭利静,谢学建,徐 杰,包 鑫.不同年龄心血管疾病患者的脂蛋白胆固醇含量与血管斑块类型的关系[J].,2024,(20):3947-3949 |
| 不同年龄心血管疾病患者的脂蛋白胆固醇含量与血管斑块类型的关系 |
| The Relationship between Lipoprotein Cholesterol Levels and Vascular Plaque Types in Cardiovascular Disease Patients of Different Ages |
| 投稿时间：2024-03-13 修订日期：2024-04-10 |
| DOI：10.13241/j.cnki.pmb.2024.20.040 |
| 中文关键词: 心血管疾病 脂蛋白胆固醇 血脂 斑块类型 不同年龄 不稳定斑块 |
| 英文关键词: Cardiovascular disease Lipoprotein cholesterol Blood lipids Patch type Different ages Unstable plaques |
| 基金项目:陕西省自然科学基础研究项目（2021JM-552） |
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| 中文摘要: |
| 摘要 目的：探讨不同年龄心血管疾病患者的脂蛋白胆固醇含量与血管斑块类型的关系。方法：选取我院2019年1月到2024年1月收治的80例心血管疾病患者作为研究对象，依照患者年龄分组并对比三组指标变化。随后将80例患者依照超声诊断斑块类型分组并对比其血脂相关指标表达水平。以斑块钙化作为因变量（稳定斑块=0，不稳定斑块=1）建立logistics回归模型分析血脂相关指标对血管斑块类型的独立预测价值。结果：不同年龄患者病程、BMI、合并高血压、糖尿病、斑块类型、Gensini评分对比差异显著（P＜0.05）；三组患者低密度脂蛋白（LDL-C）、血红蛋白水平对比差异显著，高龄组LDL-C水平高于低龄组与中龄组，血红蛋白水平低于低龄组与中龄组（P＜0.05）；不稳定斑块组患者LDL-C、HDL-C、TC、TG表达水平明显高于稳定斑块组（P＜0.05）；LDL-C升高对于心血管疾病患者不稳定斑块具有独立预测价值（P＜0.05）。结论：不同年龄心血管疾病患者LDL-C具有明显差异，高龄患者LDL-C水平较高，且高龄患者斑块多为不稳定斑块。不同斑块性质患者LDL-C、HDL-C、TC、TG均具有显著差异，但仅有LDL-C对于斑块性质判定具有独立预测价值。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the relationship between lipoprotein cholesterol content and vascular plaque type in patients with cardiovascular diseases of different ages. Methods: 80 patients with cardiovascular diseases admitted to our hospital from January 2019 to January 2024 were selected as the study objects, grouped according to their age and compared with three groups of indicators. Subsequently, 80 patients were grouped according to ultrasound diagnostic plaque type and their expression levels of lipid-related indicators were compared. When plaque calcification was used as the dependent variable (stable plaque =0, unstable plaque =1), a logistics regression model was established to analyze the independent predictive value of blood lipid-related indicators on vascular plaque type. Results: Course of disease, BMI, hypertension, diabetes, plaque type and Gensini scores of different ages (P<0.05); Low density lipoprotein (LDL-C) and hemoglobin levels were significantly in the three groups, LDL-C levels were higher in the advanced age group than in the younger and middle age group, The hemoglobin level was lower than that of the younger and middle age groups (P<0.05); The expression levels of LDL-C, HDL-C, TC and TG in unstable plaque group were significantly higher than those in stable plaque group (P<0.05); LDL-C elevation had an independent predictive value for unstable plaques in patients with cardiovascular disease (P<0.05). Conclusion: LDL-C has different ages, higher LDL-C level, and older plaques were mostly unstable plaques. LDL-C, HDL-C, TC and TG, but only LDL-C had independent predictive value for plaque properties. |
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