| 薛艳艳,邵 平,刘惠杰,孙占娟,相 婷.类风湿关节炎患者血清骨硬化蛋白、盐诱导激酶2与骨质疏松症的关系[J].,2024,(20):3903-3905 |
| 类风湿关节炎患者血清骨硬化蛋白、盐诱导激酶2与骨质疏松症的关系 |
| Relationship between Serum Sclerostin, Salt-Induced Kinase 2 and Osteoporosis in Rheumatoid Arthritis Patients |
| 投稿时间：2024-05-05 修订日期：2024-05-30 |
| DOI：10.13241/j.cnki.pmb.2024.20.026 |
| 中文关键词: 类风湿关节炎 骨质疏松症 骨硬化蛋白 盐诱导激酶2 |
| 英文关键词: Rheumatoid arthritis Osteoporosis Sclerostin Salt-induced kinase 2 |
| 基金项目:连云港市老龄健康面上科研项目（L202111）；江苏省卫生计生委科研项目（H20170658） |
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| 中文摘要: |
| 摘要 目的：研究探讨类风湿关节炎患者血清骨硬化蛋白（SOST）、盐诱导激酶2（SIK2）与骨质疏松症的关系。方法：选取2020年9月~2023年9月本院收治的180例类风湿关节炎患者为对象，根据患者骨质疏松症发生情况将其分为骨质疏松组和非骨质疏松组，比较两组患者血清SOST、SIK2水平及其他临床资料，并采用Logistic多因素回归分析类风湿关节炎患者发生骨质疏松症的影响因素。结果：骨质疏松组年龄、类风湿关节炎病程、女性比例、使用糖皮质激素比例大于非骨质疏松组，血清SOST、SIK2均高于非骨质疏松组（P<0.05）。经Logistic多因素回归分析显示，高龄、类风湿关节炎病程长、SOST、SIK2升高是类风湿关节炎发生骨质疏松症的危险因素（P<0.05）。结论：血清SOST、SIK2在类风湿关节炎合并骨质疏松症患者中升高，且血清SOST、SIK2升高是类风湿关节炎患者发生骨质疏松症的危险因素。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum sclerostin (SOST), salt-induced kinase 2 (SIK2) and osteoporosis in rheumatoid arthritis patients. Methods:
A total of 180 rheumatoid arthritis patients admitted to our hospital from September 2020 to September 2023 were selected and divided into osteoporosis group and non-osteoporosis group according to the occurrence of osteoporosis. Serum SOST, SIK 2 levels and other clinical data were compared between the two groups, and Logistic multivariate regression was used to analyze the influencing factors of osteoporosis in patients with rheumatoid arthritis. Results: Age, rheumatoid arthritis duration, female proportion and glucocorticoid use in the osteoporosis group were greater than the non-osteoporosis group, and Serum SOST and SIK 2 were higher than the non-osteoporosis group (P<0.05). The advanced age, long duration of rheumatoid arthritis, elevated SOST and elevated SIK 2 were risk factors for rheumatoid arthritis with osteoporosis by Logistic multiple regression analysis (P<0.05). Conclusion: Serum SOST and SIK 2 were elevated in patients with rheumatoid arthritis complicated with osteoporosis, and elevated serum SOST and SIK 2 are the risk factors for osteoporosis in patients with rheumatoid arthritis. |
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