| 曹守纪,王昭昕,王 岩,高希涛,李淑琴.甲状腺癌组织miR-338-3p、RAB23表达与临床病理特征及预后的关系[J].,2024,(20):3897-3899 |
| 甲状腺癌组织miR-338-3p、RAB23表达与临床病理特征及预后的关系 |
| Relationship between the Expression of miR-338-3p and RAB23 in Thyroid Cancer Tissues and Clinicopathological Features and Prognosis |
| 投稿时间：2024-06-28 修订日期：2024-07-20 |
| DOI：10.13241/j.cnki.pmb.2024.20.024 |
| 中文关键词: 甲状腺癌 微小核糖核酸-338-3p Ras癌基因家族成员23 病理特征 预后 |
| 英文关键词: Thyroid cancer Microribonucleic acid-338-3p Ras oncogene family member 23 Pathological features Prognosis |
| 基金项目:江苏省社会发展面上项目（BE2019693） |
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| 摘要点击次数: 19 |
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| 中文摘要: |
| 摘要 目的：探讨甲状腺癌（TC）组织微小核糖核酸-338-3p（miR-338-3p）、Ras癌基因家族成员23（RAB23）表达与临床病理特征及预后的关系。方法：收集217例TC患者术中切除的TC组织、癌旁组织。检测TC组织和癌旁组织中miR-338-3和RAB23 mRNA表达。分析miR-338-3p和RAB23 mRNA表达与TC临床病理特征的关系。Kaplan-Meier法对高/低miR-338-3p、RAB23 mRNA表达组TC患者进行生存分析。多因素Cox回归分析TC患者预后不良的影响因素。结果：与癌旁组织比较，TC组织中miR-338-3p表达降低，RAB23 mRNA表达升高（P＜0.05）。miR-338-3p、RAB23 mRNA表达与病理类型、TNM分期、淋巴结转移有关（P＜0.05）。 随访3年，217例TC患者3年总生存率为83.41%（181/217）。miR-338-3p高表达组3年总生存率高于miR-338-3p低表达组，RAB23 mRNA高表达组3年总生存率低于RAB23 mRNA低表达组（P＜0.05）。多因素Cox回归分析结果显示，miR-338-3p＜0.62、RAB23 mRNA≥2.13、淋巴结转移、TNM分期Ⅲ～Ⅳ期、甲状腺低/未分化癌为TC患者预后不良的独立危险因素。结论：TC组织中miR-338-3p呈低表达、RAB23 mRNA呈高表达，是TC患者预后不良的危险因素，二者与TC患者病理类型、TNM分期、淋巴结转移有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the expression of microribonucleic acid-338-3p (miR-338-3p) and Ras oncogene family member 23 (RAB23) in thyroid cancer (TC) tissues and clinicopathological features and prognosis. Methods: The intraoperatively resected TC tissues and adjacent tissues from 217 TC patients were collected. The expressions of miR-338-3p and the expressions of RAB23 mRNA in TC tissues and adjacent tissues were detected. The relationship between the expression of miR-338-3p and the expressions of RAB23 mRNA and the clinicopathological features of TC was analyzed. Kaplan-Meier method was used to analyze the survival of TC patients with high / low miR-338-3p and RAB23 mRNA expression. The influencing factors of poor prognosis in TC patients were analyzed by multivariate Cox regression. Results: Compared with adjacent tissues, the expression of miR-338-3p in TC tissues was decreased, and the expression of RAB23 mRNA was increased (P<0.05). The expression of miR-338-3p and RAB23 mRNA was related to pathological type, TNM stage and lymph node metastasis (P<0.05). After 3 years of follow-up, the 3-year overall survival rate of 217 TC patients was 83.41%(181/217). The 3-year overall survival rate in miR-338-3p high expression group was higher than that in miR-338-3p low expression group, and the 3-year overall survival rate in RAB23 mRNA high expression group was lower than that in RAB23 mRNA low expression group (P<0.05). Multivariate Cox regression analysis showed that, miR-338-3p<0.62, RAB23 mRNA≥2.13, lymph node metastasis, TNM stage III~IV and low-thyroid/undifferentiated carcinoma were independent risk factors for poor prognosis in TC patients. Conclusion: The low expression of miR-338-3p and the high expression of RAB23 mRNA in TC tissues are risk factors for poor prognosis of TC patients, TNM stage and lymph node metastasis of TC patients. |
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