| 赵志永,孙其中,丁旭东,王慧敏,刘囡囡.弥散加权成像参数联合血清LncRNA-NEAT1、miR-182-5p对脑胶质瘤术前分级的评估价值[J].,2024,(20):3881-3883 |
| 弥散加权成像参数联合血清LncRNA-NEAT1、miR-182-5p对脑胶质瘤术前分级的评估价值 |
| Value of Diffusion-Weighted Imaging Parameters Combined with Serum LncRNA-NEAT1 and miR-182-5p in the Evaluation of Preoperative Grading of Brain Glioma |
| 投稿时间：2024-05-16 修订日期：2024-06-15 |
| DOI：10.13241/j.cnki.pmb.2024.20.019 |
| 中文关键词: 脑胶质瘤 术前分级 弥散加权成像 LncRNA-NEAT1 miR-182-5p |
| 英文关键词: Brain glioma Preoperative grading Diffusion-weighted imaging LncRNA-NEAT1 miR-182-5p |
| 基金项目:山东省自然科学基金项目（ZR2021MH216） |
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| 中文摘要: |
| 摘要 目的：探讨弥散加权成像（DWI）参数联合血清长链非编码核糖核酸-核富集丰富转录本1（LncRNA-NEAT1）、microRNA（miR）-182-5p对脑胶质瘤术前分级的评估价值。方法：112例脑胶质瘤患者根据术后病理分级将其分为低级别组（60例）和高级别组（52例）。术前所有患者接受DWI检查获得表观弥散系数（ADC）、相对ADC（rADC）参数。检测脑胶质瘤患者的血清LncRNA-NEAT1、miR-182-5p表达。受试者工作特征（ROC）曲线分析DWI参数联合血清LncRNA-NEAT1、miR-182-5p诊断脑胶质瘤术前分级的价值。结果：高级别组ADC、rADC值低于低级别组（P＜0.05），血清LncRNA-NEAT1、miR-182-5p高于低级别组（P＜0.05）。ADC、rADC、LncRNA-NEAT1、miR-182-5p诊断脑胶质瘤术前高分级的曲线下面积（AUC）分别为0.834（95%CI：0.756~0.896）、0.840（95%CI：0.762~0.900）、0.784（95%CI：0.700~0.853）、0.812（95%CI：0.731~0.878），联合诊断AUC为0.959（95%CI：0.907~0.987），高于单独指标诊断。结论：高级别脑胶质瘤患者ADC、rADC降低，血清LncRNA-NEAT1、miR-182-5p升高，联合DWI参数（ADC、rADC）和血清LncRNA-NEAT1、miR-182-5p检测对脑胶质瘤术前分级具有较高的诊断价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the value of diffusion-weighted imaging (DWI) parameters combined with serum long-chain non-coding ribonucleic acids-nuclear enrichment rich transcript 1 (LncRNA-NEAT1) and microRNA (miR)-182-5p in the evaluation of preoperative grading of brain glioma. Methods: 112 brain glioma patients were divided into low-level group (60 cases) and high-level group (52 cases) according to postoperative pathological grading. All patients underwent DWI examination before operation to obtain apparent diffusion coefficient (ADC) and relative ADC (rADC) parameters. The expression of serum LncRNA-NEAT1 and miR-182-5p in brain glioma patients was detected. The value of DWI parameters combined with serum LncRNA-NEAT1 and miR-182-5p in the diagnosis of preoperative grading of brain glioma was analyzed by receiver operating characteristic (ROC) curve. Results: The ADC and rADC values in high-level group were lower than those in low-level group (P<0.05), and the serum LncRNA-NEAT1 and miR-182-5p were higher than those in low-level group (P<0.05). The area under the curve (AUC) of ADC, rADC, LncRNA-NEAT1 and miR-182-5p in the diagnosis of preoperative high-grade brain glioma was 0.834(95%CI: 0.756~0.896), 0.840(95%CI: 0.762~0.900), 0.784(95%CI: 0.700~0.853), and 0.812(95%CI: 0.731~0.878) respectively. AUC of combined diagnosis was 0.959(95%CI: 0.907~0.987), which was higher than that of single index diagnosis. Conclusion: The ADC and rADC of patients with high-grade brain glioma decrease, and the serum LncRNA-NEAT1 and miR-182-5p increase, the combination of DWI parameters (ADC, rADC) and serum LncRNA-NEAT1 and miR-182-5p detection has high diagnostic value for preoperative grading of brain glioma. |
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