| 程 雪,陆月兰,王 晨,陈 慧,孙德明,董宇超.特发性间质性肺炎急性加重期患者血清TBIL、LDH、LTBP2检测的临床意义分析[J].,2024,(20):3857-3859 |
| 特发性间质性肺炎急性加重期患者血清TBIL、LDH、LTBP2检测的临床意义分析 |
| Clinical Significance Analysisof Serum TBIL, LDH and LTBP2 Detection in Patients with Acute Exacerbation of Idiopathic Interstitial Pneumonia |
| 投稿时间：2024-05-05 修订日期：2024-05-30 |
| DOI：10.13241/j.cnki.pmb.2024.20.012 |
| 中文关键词: 特发性间质性肺炎 急性加重期 TBIL LDH LTBP2 预后 |
| 英文关键词: Idiopathic interstitial pneumonia Acute exacerbation TBIL LDH LTBP2 Prognosis |
| 基金项目:上海市科委科研项目（19411950402） |
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| 中文摘要: |
| 摘要 目的：探讨特发性间质性肺炎急性加重期（AE-IIP）患者血清总胆红素（TBIL）、乳酸脱氢酶（LDH）、潜在转化生长因子β结合蛋白2（LTBP2）水平与预后的关系。方法：选取2018年1月～2023年8月我院收治的AE-IIP患者102例（AE-IIP组），根据随访3个月生存状态分为死亡组（30例）和存活组（72例），通过多因素Logistic回归分析AE-IIP患者死亡的因素。结果：与存活组比较，死亡组血清TBIL水平降低，LDH、LTBP2水平升高（P＜0.05）。AE-IIP患者死亡的独立保护因素为一氧化碳弥散量（DLCO）、动脉血氧分压/吸氧分数（PaO2 /FiO2）升高、TBIL升高，独立危险因素为LDH升高、LTBP2升高（P＜0.05）。结论：AE-IIP患者血清TBIL水平降低和LDH、LTBP2水平升高，与不良预后密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum total bilirubin (TBIL), lactate dehydrogenase (LDH), latent transforming growth factor beta binding protein 2 (LTBP2) levels and prognosis in patients with acute exacerbation of idiopathic interstitial pneumonia (AE-IIP). Methods: 102 patients with AE-IIP (AE-IIP group) admitted to our hospital from January 2018 to August 2023 were selected, patients were divided into death group (30 cases) and survival group (72 cases) according to the survival status after 3 months of follow-up. The factors of death in patients with AE-IIP were analyzed by multivariate Logistic regression. Results: Compared with survival group, the serum TBIL level in death group was decreased, and the levels of LDH and LTBP2 were increased (P<0.05). The independent protective factors of death in patients with AE-IIP were increased dynamic diffusion lung capacity of carbon monoxide (DLCO), partial pressure of oxygen/fraction of inspired oxygen (PaO2/FiO2), and TBIL, the independent risk factors were increased LDH and LTBP2 (P<0.05). Conclusion: The decrease of serum TBIL level and the increase of LDH and LTBP2 levels in patients with AE-IIP are closely relate to the poor prognosis. |
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