| 朱 洁,周炳荣,陆 燕,郭 琴,吉 津,陈 芳,刘 佳,徐 萍.舒敏专家联合A型肉毒毒素对玫瑰痤疮患者面部症状、皮肤屏障功能及血清IL-1、IL-6和IL-37水平的影响[J].,2024,(20):3854-3856 |
| 舒敏专家联合A型肉毒毒素对玫瑰痤疮患者面部症状、皮肤屏障功能及血清IL-1、IL-6和IL-37水平的影响 |
| Effects of Shumin Experts Combined with Botulinum Toxin Type A on Facial Symptoms, Skin Barrier Function and Serum IL-1, IL-6 and IL-37 Levels in Rosacea Patients |
| 投稿时间：2024-05-16 修订日期：2024-06-08 |
| DOI：10.13241/j.cnki.pmb.2024.20.011 |
| 中文关键词: 舒敏专家 A型肉毒毒素 玫瑰痤疮 面部症状 皮肤屏障功能 IL-1 IL-6 IL-37 |
| 英文关键词: Shumin expert Botulinum toxin type A Rosacea Facial symptoms Skin barrier function IL-1 IL-6 IL-37 |
| 基金项目:国家自然科学基金项目（82073472） |
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| 中文摘要: |
| 摘要 目的：观察舒敏专家联合A型肉毒毒素（BTX-A）对玫瑰痤疮患者面部症状、皮肤屏障功能及血清白细胞介素-1（IL-1）、白细胞介素-6（IL-6）和白细胞介素-37（IL-37）水平的影响。方法：按照随机数字表法将120例玫瑰痤疮患者分为对照1组、对照2组、研究组，各40例。对照1组接受BTX-A治疗，对照2组接受舒敏专家治疗，研究组接受舒敏专家联合BTX-A治疗。对比三组疗效、面部症状评分、皮肤屏障功能[经皮水分丢失量（TEWL）、油脂含量、表皮含水量，皮肤pH值]及血清IL-1、IL-6和IL-37水平。结果：研究组的临床总有效率高于对照1组和对照2组（P<0.05）。研究组治疗后毛细血管扩张、红斑、皮肤潮红、丘疹脓疱评分、TEWL、皮肤pH值和血清IL-1、IL-6、IL-37水平低于对照1组和对照2组，油脂含量、表皮含水量高于对照1组和对照2组（P<0.05）。结论：舒敏专家联合BTX-A治疗玫瑰痤疮，可有效改善患者的面部症状和皮肤屏障功能，降低血清IL-1、IL-6和IL-37水平。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of shumin experts combined with botulinum toxin type A (BTX-A) on facial symptoms, skin barrier function and serum interleukin-1 (IL-1), interleukin-6 (IL-6) and interleukin-37 (IL-37) levels in rosacea patients. Methods:120 rosacea patients were divided into control group 1, control group 2 and study group according to the random number table method, with 40 cases in each group. Control group 1 received BTX-A treatment, control group 2 received shumin expert treatment, and study group received shumin expert combined with BTX-A treatment. The efficacy, facial symptom score, skin barrier function [transcutaneous water loss (TEWL), oil content, epidermal water content, skin pH value] and serum IL-1, IL-6 and IL-37 levels were compared in three groups. Results: The total clinical effective rate in study group was higher than that in control group 1 and control group 2 (P<0.05). The scores of angiotelectasis, erythema, erubescence, papulopustule, TEWL, skin pH value and serum IL-1, IL-6 and IL-37 levels in study group were lower than those in control group 1 and control group 2 after treatment, while the oil content and epidermal water content were higher than those in control group 1 and control group 2 (P<0.05). Conclusion: Shumin experts combined with BTX-A in the treatment of rosacea, which can effectively improve the facial symptoms and skin barrier function of patients, reduce the levels of serum IL-1, IL-6 and IL-37. |
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