| 张 娜,刘 翠,孟令军,李 敏,孙长青.宫颈癌患者血清LOXL2、PKM2与根治术后远期复发的关系[J].,2024,(18):3554-3558 |
| 宫颈癌患者血清LOXL2、PKM2与根治术后远期复发的关系 |
| Relationship between Serum LOXL2, PKM2 and Long-Term Recurrence after Radical Resection in Patients with Cervical Cancer |
| 投稿时间：2024-01-06 修订日期：2024-01-31 |
| DOI：10.13241/j.cnki.pmb.2024.18.029 |
| 中文关键词: 宫颈癌 LOXL2 PKM2 根治术 远期复发 |
| 英文关键词: Cervical cancer LOXL2 PKM2 Radical resection Long-term recurrence |
| 基金项目:山东省医药卫生科技发展计划项目（202209011090） |
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| 中文摘要: |
| 摘要 目的：研究宫颈癌患者血清赖氨酰氧化酶样蛋白-2（LOXL2）及丙酮酸激酶M2型（PKM2）与根治术后远期复发的关系。方法：选取2017年1月至2018年3月山东大学齐鲁医院德州医院接受根治术治疗的宫颈癌患者305例作为观察对象，患者随访5年，失访3例。根据患者是否远期复发分成复发组（72例）以及未复发组（230例）。比较复发组与未复发组两组血清LOXL2及PKM2水平。采用多因素Logistic回归分析根治术后远期复发的影响因素，以受试者工作特征曲线（ROC）分析血清LOXL2联合PKM2对根治术后患者远期复发的预测价值。结果：302例患者术后5年共复发72例，复发率为23.84%（72/302）。复发组血清LOXL2及PKM2水平均较未复发组更高（P＜0.05）。多因素Logistic回归分析发现，手术方式为腹腔镜术式、浸润深度≥1/2肌层、有淋巴结转移、LOXL2升高及PKM2升高均为患者术后远期复发的危险因素（P＜0.05）。ROC曲线分析显示，血清LOXL2联合PKM2对根治术后患者远期复发的预测价值最高，其中，曲线下面积（AUC）为0.921，敏感度为95.24%。结论：宫颈癌患者的血清LOXL2及PKM2水平升高，且是根治术后远期复发的危险因素。血清LOXL2联合PKM2对术后患者远期复发的预测价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between serum lysyl oxidase like-2 protein (LOXL2) and pyruvate kinase M2 (PKM2) and long-term recurrence after radical resection in patients with cervical cancer. Methods: 302 patients with cervical cancer who underwent radical surgery in Qilu Hospital of Shandong University Dezhou Hospital from January 2017 to March 2018 were selected as observation subjects, the patients were followed up for 5 years, and 3 cases were lost to follow-up. The patients were divided into recurrence group (72 cases) and non-recurrence group (230 cases) according to whether the patients had long-term recurrence. The levels of serum LOXL2 and PKM2 were compared between recurrence group and non-recurrence group. The influencing factors of long-term recurrence after radical resection were analyzed by multivariate Logistic regression analysis, the predictive value of serum LOXL2 combined with PKM2 for long-term recurrence after radical resection were analyzed by receiver operating characteristic(ROC) curve. Results: There were 72 cases of recurrence in 302 patients 5 years after operation, and the recurrence rate was 23.84% (72/302). The serum levels of LOXL2 and PKM2 in recurrence group were higher than those in non-recurrence group (P<0.05). Multivariate Logistic regression analysis showed that, the surgical mode was laparoscopic surgery, infiltration depth≥1/2 muscular layer, lymph node metastasis, elevated LOXL2 and elevated PKM2 were risk factors for long-term recurrence after operation (P<0.05). ROC curve analysis showed that, serum LOXL2 combined with PKM2 had the highest predictive value for long-term recurrence in patients after radical resection, the area under curve (AUC) was 0.921, and the sensitivity was 95.24%. Conclusion: The levels of serum LOXL2 and PKM2 in patients with cervical cancer are increase, and they are risk factors for long-term recurrence after radical resection. Serum LOXL2 combine with PKM2 has a high predictive value for long-term recurrence in patients after surgery. |
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