| 耿晓丽,纪 霞,杜海燕,任奇志,张 荣.血清PAEs、CA125及RBP-4与卵巢囊肿患者卵巢储备功能的相关性及其诊断价值分析[J].,2024,(18):3475-3479 |
| 血清PAEs、CA125及RBP-4与卵巢囊肿患者卵巢储备功能的相关性及其诊断价值分析 |
| Correlation and Diagnostic Value Analysis of Serum PAEs, CA125, and RBP-4 with Ovarian Reserve Function in Patients with Ovarian Cysts |
| 投稿时间：2024-02-06 修订日期：2024-02-27 |
| DOI：10.13241/j.cnki.pmb.2024.18.014 |
| 中文关键词: 酞酸酯类化学物 糖类抗原125 视黄醇结合蛋白-4 卵巢囊肿 卵巢储备功能 诊断价值 |
| 英文关键词: Phthalate ester chemicals Carbohydrate antigen 125 Retinol binding protein-4 Ovarian cyst Ovarian reserve function Diagnostic value |
| 基金项目:内蒙古自治区自然科学基金项目（2020MS08180） |
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| 中文摘要: |
| 摘要 目的：探讨血清酞酸酯类化学物（PAEs）、糖类抗原125（CA125）及视黄醇结合蛋白-4（RBP-4）与卵巢囊肿患者卵巢储备功能的相关性及其诊断价值。方法：选取我院2020年1月到2022年12月收治的150例卵巢囊肿患者，为观察组，另选取同期体检的150名健康志愿者作为对照组。对比两组受检者血清PAEs{邻苯二甲酸二乙酯（DEP）、邻苯二甲酸二丁酯（DBP）、邻苯二甲酸（2-乙基己基）酯[di-（2-ethylheyl）]（DEHP）}、CA125、RBP-4及卵巢储备功能相关指标表达水平，采用Pearson检验分析血清PAEs、CA125及RBP-4与卵巢囊肿患者卵巢储备功能的相关性，并建立受试者工作特征（ROC）曲线分析血清PAEs、CA125及RBP-4对卵巢囊肿的诊断价值。结果：观察组血清PAEs、CA125及DEP、DBP、DEHP和PAEs总水平明显高于对照组（P＜0.05）；观察组卵巢储备功能相关指标卵泡雌激素（FSH）、黄体生成素（LH）水平明显高于对照组，雌二醇（E2）水平明显低于对照组（P＜0.05）；PAEs、CA125及RBP-4分别与FSH、LH呈正相关，与E2呈负相关（P＜0.05）；曲线下面积(AUC)从高到低依次为联合诊断（0.864）、RBP-4（0.721）、CA125（0.698）、PAEs（0.641）。PAEs、CA125及RBP-4三者联合对卵巢囊肿的诊断灵敏度、特异度高于三者单一诊断。结论：血清PAEs、CA125及RBP-4与卵巢囊肿患者卵巢储备功能具有显著关系，三者水平越高代表卵巢囊肿患者卵巢储备功能越差，另外PAEs、CA125及RBP-4联合对于卵巢囊肿具有较高的诊断灵敏度与特异性，可为卵巢囊肿的临床诊断及病情判断提供可靠依据。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the correlation and diagnostic value of serum phthalate ester chemicals (PAEs), carbohydrate antigen 125 (CA125), and retinol binding protein-4 (RBP-4) with ovarian reserve function in patients with ovarian cysts. Methods: A total of 150 ovarian cyst patients admitted to our hospital from January 2020 to December 2022 were selected as the observation group, and another 150 healthy volunteers with physical examination in the same period were selected as the matched group. Compare the expression levels of serum PAEs {diethyl phthalate (DEP), dibutyl phthalate (DBP), and 2-ethylhexyl phthalate (di-(2-ethylhexyl)) (Di - (2-ethylhexyl) phthalate (DEHP)}, CA125, RBP-4, and ovarian function related indicators between two groups of subjects. Use Pearson's test to analyze the expression levels of serum PAEs The correlation between CA125 and RBP-4 and ovarian reserve function in patients with ovarian cysts, and the establishment of receiver operating characteristic (ROC) curves to analyze the diagnostic value of serum PAEs, CA125, and RBP-4 for ovarian cysts. Results: The total levels of serum PAEs, CA125, DEP, DBP, DEHP, and PAEs in the observation group were higher than those in the matched group (P<0.05); The levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) in the observation group were higher than those in the matched group, while the levels of estradiol (E2) were lower than those in the matched group(P<0.05); PAEs, CA125, and RBP-4 were positively correlated with FSH and LH, and negatively correlated with E2 (P<0.05); The area under the curve (AUC) from high to low is joint diagnosis (0.864), RBP-4 (0.721), CA125 (0.698), and PAEs (0.641). The combination of PAEs, CA125, and RBP-4 has higher diagnostic sensitivity and specificity for ovarian cysts compared to a single diagnosis of the three. Conclusion: There is a significant relationship between serum PAEs, CA125, and RBP-4 levels and ovarian reserve function in patients with ovarian cysts. The higher the levels of these three, the worse the ovarian reserve function in patients with ovarian cysts. In addition, the combination of PAEs, CA125, and RBP-4 has high diagnostic sensitivity and specificity for ovarian cysts, which can provide reliable basis for clinical diagnosis and disease judgment of ovarian cysts. |
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