| 刘宇莹,魏思雨,樊丽颖,魏 缇,张家新.全身炎症反应指数、血清TK1、CRP/ALB比值与三阴性乳腺癌患者术后复发转移的关系[J].,2024,(18):3470-3474 |
| 全身炎症反应指数、血清TK1、CRP/ALB比值与三阴性乳腺癌患者术后复发转移的关系 |
| Relationship between Systemic Inflammatory Response Index, Serum TK1, CRP/ALB Ratio and Postoperative Recurrence and Metastasis in Patients with Triple Negative Breast Cancer |
| 投稿时间：2024-02-18 修订日期：2024-03-12 |
| DOI：10.13241/j.cnki.pmb.2024.18.013 |
| 中文关键词: 三阴性乳腺癌 全身炎症反应指数 胸苷激酶1 C反应蛋白/白蛋白比值 复发转移 |
| 英文关键词: Triple negative breast cancer Systemic inflammatory response index Thymidine kinase 1 C-reactive protein/albumin ratio Recurrence and metastasis |
| 基金项目:江苏省中医药科技发展计划面上项目（MS2021101）；中国乳腺肿瘤青年学者科研项目（CYBER-2021-010）；徐州市重点研发计划社会发展项目（KC21218）；国家自然科学基金青年基金项目（81602321）；江苏省研究生科研与实践创新计划项目（SJCX22_1266） |
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| 中文摘要: |
| 摘要 目的：探讨全身炎症反应指数（SII）、血清胸苷激酶1（TK1）、C反应蛋白/白蛋白（CRP/ALB）比值与三阴性乳腺癌（TNBC）患者术后复发转移的关系。方法：选取2018年1月～2020年5月徐州医科大学附属医院收治268例TNBC患者，根据术后3年是否复发转移分为复发转移组和无复发转移组。计算术前SII、CRP/ALB比值和检测血清TK1水平。多因素Logistic回归分析TNBC患者术后复发转移的因素，受试者工作特征（ROC）曲线分析SII、血清TKI、CRP/ALB比值对TNBC患者术后复发转移的预测价值。结果：随访3年，268例TNBC患者术后复发转移率为25.00%（67/268）。与无复发转移组比较，复发转移组SII、血清TKI、CRP/ALB比值升高（P＜0.05）。TNBC患者术后复发转移的独立危险因素为TNM分期Ⅲ期、淋巴结转移和SII、血清TKI、CRP/ALB比值升高（P＜0.05）。SII、血清TKI、CRP/ALB比值联合预测TNBC患者术后复发转移的曲线下面积为0.917，大于SII、血清TKI、CRP/ALB比值单独预测的0.789、0.779、0.781。结论：SII、血清TKI、CRP/ALB比值升高与TNBC患者术后复发转移密切相关，联合SII、血清TKI、CRP/ALB比值对TNBC患者术后复发转移的预测价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between systemic inflammatory response index (SII), serum thymidine kinase 1 (TK1), C-reactive protein/albumin (CRP/ALB) ratio and postoperative recurrence and metastasis in patients with triple negative breast cancer (TNBC). Methods: 268 TNBC patients admitted to the Affiliated Hospital of Xuzhou Medical University from January 2018 to May 2020 were selected and divided into recurrent metastasis group and non recurrent metastasis group according to whether they had recurrent metastasis 3 years after surgery. Calculated preoperative SII, CRP/ALB ratio and detected serum TK1 level. The factors of postoperative recurrence and metastasis in TNBC patients were analyzed by multivariate Logistic regression, the predictive value of SII, serum TKI and CRP/ALB ratio for postoperative recurrence and metastasis in TNBC patients was analyzed by receiver operating characteristic (ROC) curve. Results: After 3 years of follow-up, the recurrence and metastasis rate of 268 TNBC patients was 25.00% (67/268). Compared with non recurrence and metastasis group, the SII, serum TKI and CRP/ALB ratio in recurrence and metastasis group increased (P<0.05). Independent risk factors for postoperative recurrent metastasis in TNBC patients were TNM stage III, lymph node metastasis and SII, serum TKI, and an elevated CRP/ALB ratio P<0.05). The area under the curve of SII, serum TKI and CRP/ALB ratio in predicting postoperative recurrence and metastasis of TNBC patients was 0.917, which was greater than 0.789, 0.779 and 0.781 predicted by SII, serum TKI and CRP/ALB ratio alone. Conclusion: The increase of SII, serum TKI and CRP/ALB ratio are closely relate to the recurrence and metastasis of TNBC patients after operation, the combination of SII, serum TKI and CRP/ALB ratio has a high predictive value for the recurrence and metastasis of TNBC patients after operation. |
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