| 沈青峰,朱永兴,代荣荣,李昱萱,靳自斌.首发未用药精神分裂症患者血清CRP、MT、IGF-1与氧化应激指标和认知功能的相关性研究[J].,2024,(17):3381-3385 |
| 首发未用药精神分裂症患者血清CRP、MT、IGF-1与氧化应激指标和认知功能的相关性研究 |
| Correlation Study of Serum CRP, MT, and IGF-1 with Oxidative Stress Indexes and Cognitive Function in Patients with First-Episode Untreated Schizophrenia |
| 投稿时间：2024-02-21 修订日期：2024-03-17 |
| DOI：10.13241/j.cnki.pmb.2024.17.035 |
| 中文关键词: 精神分裂症 CRP MT IGF-1 氧化应激 认知功能 相关性 |
| 英文关键词: Schizophrenia CRP MT IGF-1 Oxidative stress Cognitive function Correlation |
| 基金项目:国家自然科学基金资助项目（81701084） |
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| 中文摘要: |
| 摘要 目的：研究首发未用药精神分裂症（SP）患者血清C反应蛋白（CRP）、褪黑素（MT）、胰岛素样生长因子-1（IGF-1）与氧化应激指标和认知功能的相关性。方法：选择从2021年1月到2023年6月在徐州医科大学附属徐州东方医院接受治疗的首发未用药SP患者140例作为观察组，按照阳性与阴性症状量表(PANSS)评分将患者分为高分组（≥70分）57例和低分组（＜70分）83例。另选同期在我院接受健康体检的志愿者140例作为对照组。检测血清氧化应激指标、CRP、MT及IGF-1水平，采用MATRICS认知评估系统(MCCB)评分评估患者认知功能障碍。分析血清CRP、MT、IGF-1与PANSS评分、血清氧化应激指标、MCCB各项评分和总分的相关性。结果：观察组血清CRP较对照组更高，MT及IGF-1较对照组更低（P＜0.05）。高分组血清CRP较低分组更高，MT及IGF-1较低分组更低（P＜0.05）。高分组血清SOD及GSH-Px较低分组更低，而NO较低分组更高（P＜0.05）。高分组MCCB各项评分及总分均较低分组更低，PANSS评分较低分组更高（P＜0.05）。Pearson相关性发现，血清CRP与PANSS评分及NO呈正相关，与SOD、GSH-Px及MCCB各项评分和总分呈负相关（P＜0.05）；血清MT和IGF-1与PANSS评分及NO呈负相关，与SOD、GSH-Px及MCCB各项评分和总分呈正相关（P＜0.05）。结论：首发未用药SP患者血清CRP水平升高，MT及IGF-1水平降低，三者均与氧化应激指标和认知功能之间有明显的相关性。 |
| 英文摘要: |
| ABSTRACT Objective: To study the correlation between serum C-reactive protein (CRP), melatonin (MT), insulin-like growth factor-1 (IGF-1) and oxidative stress indexes and cognitive function in patients with first-episode untreated schizophrenia (SP). Methods: 140 patients with first-episode untreated SP who were treated in Xuzhou Oriental Hospital Affiliated to Xuzhou Medical University from January 2021 to June 2023 were selected as observation group, the patients were divided into high score group (≥70 points) with 57 cases and low score group (<70 points) with 83 cases according to the positive and negative symptom scale (PANSS) score. Another 140 volunteers who received physical examination in our hospital during the same period were selected as control group. Serum oxidative stress indexes, CRP, MT and IGF-1 levels were detected, and patients' cognitive dysfunction was evaluated by MATRICS cognitive assessment system (MCCB) score. The correlation between serum CRP, MT, IGF-1 and PANSS score, serum oxidative stress index, MCCB score and total score was analyzed. Results: Serum CRP in observation group was higher than that in control group, and MT and IGF-1 were lower than those in control group (P<0.05). The serum CRP in high score group was higher than that in low score group, and the MT and IGF-1 were lower than those in low score group (P<0.05). Serum SOD and GSH-Px in high score group were lower than those in low score group, while NO was higher than that in low score group (P<0.05). The MCCB scores and total scores in high score group were lower than those in low score group, and the PANSS score was higher than that in low score group (P<0.05). Pearson correlation showed that, serum CRP was positively correlated with PANSS score and NO, and negatively correlated with SOD, GSH-Px and MCCB scores and total scores (P<0.05). Serum MT and IGF-1 were negatively correlated with PANSS score and NO, and positively correlated with SOD, GSH-Px and MCCB scores and total score (P<0.05). Conclusion: The level of serum CRP in patients with first-episode untreated SP increase, and the levels of MT and IGF-1 decrease, there is a significant correlation between the three and oxidative stress indicators and cognitive function. |
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