| 张 梅,马 燕,康淑琴,袁 雁,鲁雪红,王 婷.COPD患者高分辨率CT分型与气道炎症、免疫功能和临床疗效的关系研究[J].,2024,(16):3123-3127 |
| COPD患者高分辨率CT分型与气道炎症、免疫功能和临床疗效的关系研究 |
| Study on the Relationship between High-Resolution CT Typing and Airway Inflammation, Immune Function, and Clinical Efficacy in COPD Patients |
| 投稿时间：2024-02-08 修订日期：2024-02-28 |
| DOI：10.13241/j.cnki.pmb.2024.16.024 |
| 中文关键词: 慢性阻塞性肺疾病 高分辨率CT 气道炎症 免疫功能 临床疗效 |
| 英文关键词: Chronic obstructive pulmonary disease High-resolution CT Airway inflammation Immune function Clinical efficacy |
| 基金项目:新疆维吾尔自治区青年科学基金项目（2022D01C812） |
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| 中文摘要: |
| 摘要 目的：研究慢性阻塞性肺疾病（COPD）患者高分辨率CT（HRCT）分型与气道炎症、免疫功能和临床疗效的关系。方法：选择从2020年5月到2023年8月在 新疆医科大学附属中医医院收治的COPD患者165例，按照HRCT影像表型分为A型组（n=81）、E型组（n=46）及M型组（n=38）。对比各组肺功能指标[第一秒用力呼气容积（FEV1），第一秒用力呼气容积占预计值百分比（FEV1%），第一秒用力呼气容积/用力肺活量（FEV1/FVC），残气量/肺总量（RV/TLC）]，气道炎症指标[C反应蛋白（CRP），白细胞介素-6（IL-6）]，免疫功能指标，以及临床疗效。结果：E型组和M型组的FEV1、FEV1%及FEV1/FVC较A型组更低，且M型组较E型组更低（P＜0.05）。E型组及M型组的RV/TLC较A型组更高，且M型组较E型组更高（P＜0.05）。A型组及E型组的CRP、IL-6较M型组更低，且E型组较A型组更低（P＜0.05）。E型组及M型组的CD3+及CD4+/CD8+较A型组更低，且M型组较E型组更低（P＜0.05）。A型组总有效率较E型组和M型组更高，且E型组较M型组更高（P＜0.05）。结论：不同HRCT分型COPD患者气道炎症、免疫功能和临床疗效之间存在着较大差异，在诊疗过程中可关注此情况，从而为临床诊治提供支持。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between high-resolution CT (HRCT) typing and airway inflammation, immune function and clinical efficacy in patients with chronic obstructive pulmonary disease (COPD). Methods: 165 COPD patients admitted to the Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University from May 2020 to August 2023 were selected, and patients were divided into type A group (n=81), type E group (n=46) and type M group (n=38) according to HRCT imaging phenotype. Pulmonary function indexes [forced expiratory volume in the first second (FEV1), percentage of forced expiratory volume in the first second to predicted value (FEV1%), forced expiratory volume in the first second/forced vital capacity (FEV1/FVC), residual volume/total lung capacity (RV/TLC)], airway inflammation indexes [C-reactive protein (CRP), interleukin-6 (IL-6)], immune function indexes and clinical efficacy were compared in each group. Results: FEV1, FEV1% and FEV1/FVC in type E group and M group were lower than those in type A group, and type M group were lower than those of type E group (P<0.05). RV/TLC in type E group and type M group was higher than that in type A group, and RV/TLC in type M group was higher than that in type E group (P<0.05). The levels of CRP and IL-6 in type A group and type E group were lower than those in type M group, and type E group were lower than those of type A group(P<0.05). CD3+ and CD4+/CD8+ in type E group and type M group were lower than those in type A group, and type M group were lower than those of type E group(P<0.05). The total effective rate in group A was higher than that in type E group and type M group, and type E group was higher than that of type M group(P<0.05). Conclusion: There are great differences in airway inflammation, immune function and clinical efficacy among COPD patients with different HRCT types, this situation can be paid attention to in the process of diagnosis and treatment, so as to provide support for clinical diagnosis and treatment. |
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