| 胡金凤,向 娟,冯 京,方 媛,崔蕊莉,王倩倩,徐 敏.血清Hcy、SOD、SDF-1与2型糖尿病患者远端对称性多发性神经病变的关系研究[J].,2024,(16):3051-3055 |
| 血清Hcy、SOD、SDF-1与2型糖尿病患者远端对称性多发性神经病变的关系研究 |
| Study on the Relationship between Serum Hcy, SOD, SDF-1 and Distal Symmetric Polyneuropathy in Patients with Type 2 Diabetes Mellitus |
| 投稿时间：2024-01-26 修订日期：2024-02-23 |
| DOI：10.13241/j.cnki.pmb.2024.16.009 |
| 中文关键词: 2型糖尿病 Hcy SOD SDF-1 远端对称性多发性神经病变 |
| 英文关键词: Type 2 diabetes mellitus Hcy SOD SDF-1 Distal symmetric polyneuropathy |
| 基金项目:北京市自然科学基金项目（L172015) |
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| 中文摘要: |
| 摘要 目的：分析血清同型半胱氨酸（Hcy）、超氧化物歧化酶（SOD）、基质细胞衍生因子-1（SDF-1）与2型糖尿病（T2DM）患者远端对称性多发性神经病变（DSPN）的关系。方法：选择2020年1月至2023年1月我院收治的146例T2DM患者为研究对象，根据是否合并DSPN，分为伴DSPN（DSPN 组）和不伴DSPN（NDSPN 组），分别为65例和81例。收集两组患者的一般临床资料（饮酒史、吸烟史、年龄、糖尿病病程、体重指数、基线血压、性别等）及血糖、血脂等生化指标值，采用酶联免疫吸附法检测血清中的Hcy、SOD和SDF-1水平。比较两组患者的血清Hcy、SOD和SDF-1水平，分析不同病情严重程度患者的血清Hcy、SOD、SDF-1水平，分析三者与DSPN病变程度的相关性，并采用受试者工作曲线（ROC）分析三者在DSPN的临床诊断中的预测价值。结果：DSPN组患者的年龄、糖尿病病程和DBP均高于NDSPN组（P<0.05）。DSPN组患者的血清SOD和SDF-1水平均显著低于NDSPN组，而Hcy水平显著高于NDSPN组（P<0.05）。血清Hcy水平随着DSPN神经病变严重程度的加重而升高，而SOD、SDF-1水平随着病变程度的加重而降低（P<0.05）。多因素Logistic回归分析结果显示，患者年龄、糖尿病病程及血清SOD、Hcy 、SDF-1水平均为DSPN的独立影响因素（P<0.05）。血清Hcy、SOD 和SDF-1水平预测T2DM患者合并DSPN的曲线下面积（AUC）分别为0.793、0.801和0.840，三者联合预测的AUC值（0.877）均高于三者单独预测DSPN的AUC值。结论：血清Hcy、SOD、SDF-1均可能参与DSPN的发生发展进程，为DSPN发生的独立影响因素，联合检测对于DSPN的临床诊断具有较高的预测价值。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the relationship between serum homocysteine (Hcy), superoxide dismutase (SOD), stromal cell-derived factor-1 (SDF-1) and distal symmetric polyneuropathy (DSPN) in patients with type 2 diabetes mellitus (T2DM). Methods: 146 T2DM patients admitted to our hospital from January 2020 to January 2023 were selected as research objects, ccording to whether they were combined with DSPN, patients were divided into DSPN (DSPN group) and non-DSPN (NDSPN group), 65 cases and 81 cases respectively. The general clinical data (drinking history, smoking history, age, duration of diabetes mellitus, body mass index, baseline blood pressure, gender, etc.) and biochemical indexes such as blood glucose and blood lipid were collected. The levels of Hcy, SOD and SDF-1 in serum were detected by enzyme-linked immunosorbent assay, the levels of serum Hcy, SOD and SDF-1 were compared between two groups, the levels of serum Hcy, SOD and SDF-1 in patients with different severity of disease were analyzed, the correlation between the three and the severity of DSPN was analyzed, and the predictive value of the three in the clinical diagnosis of DSPN were analyzed by receiver operating curve(ROC). Results: The age, duration of diabetes mellitus and DBP in DSPN group were higher than those in NDSPN group (P<0.05). The serum SOD and SDF-1 levels in DSPN group were significantly lower than those in NDSPN group, while the Hcy level was significantly higher than that in NDSPN group (P<0.05). The level of serum Hcy increased with the severity of DSPN neuropathy, while the levels of SOD and SDF-1 decreased with the severity of DSPN neuropathy(P<0.05). Multivariate Logistic regression analysis showed that, age, duration of diabetes mellitus and serum levels of SOD, Hcy and SDF-1 were independent influencing factors of DSPN (P<0.05). The area under the curve (AUC) of serum Hcy, SOD and SDF-1 levels for predicting DSPN in T2DM patients was 0.793, 0.801 and 0.840 respectively, the AUC value of the combined prediction of the three (0.877) was higher than that of the three alone. Conclusion: Serum Hcy, SOD and SDF-1 may be involve in the occurrence and development of DSPN, which are independent influencing factors of DSPN, and joint testing have high predictive value for the clinical diagnosis of DSPN. |
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