| 李丽丽,方怡然,刘 璇,姚 璇,唐晓伟.肠道益生菌联合健身气功八段锦治疗慢性阻塞性肺（疾病）患者疗效及对RANKL、血气指标的影响[J].,2024,(15):2882-2886 |
| 肠道益生菌联合健身气功八段锦治疗慢性阻塞性肺（疾病）患者疗效及对RANKL、血气指标的影响 |
| Efficacy of Intestinal Probiotics Combined with Health Qigong Baduanjin in Treating Patients with Chronic Obstructive Pulmonary (Disease) and Its Effect on RANKL and Blood Gas Index |
| 投稿时间：2024-02-06 修订日期：2024-02-27 |
| DOI：10.13241/j.cnki.pmb.2024.15.014 |
| 中文关键词: 肠道益生菌 气功八段锦 慢性阻塞性肺疾病 |
| 英文关键词: Intestinal probiotics Qigong Eight Section Brocade COPD |
| 基金项目:江苏省卫生健康委科研课题（BJ21033） |
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| 中文摘要: |
| 摘要 目的：探讨肠道益生菌联合健身气功八段锦治疗慢性阻塞性肺（疾病）患者疗效及对核因子κB受体活化因子配体（RANKL）、血气指标的影响。方法：选取2018年1月到2023年12月收治的88例COPD稳定期患者，分为观察组与对照组，各组均44例。对照组患者采取常规西医治疗，观察组在对照组基础上增加肠道益生菌联合健身气功八段锦治疗。采取肺功能、6min步行试验（6MWT）、慢性阻塞性肺疾病评定量表（CAT）对其治疗效果进行评价，对比两组患者治疗前后炎症反应指标及RANKL水平变化，并对比两组患者血气指标及生活质量。结果：治疗后两组患者FEV1、FVC、FEV1/ FVC、6MWT均升高，CAT评分降低，观察组与对照组比较有相同趋势（P＜0.05）；治疗后两组患者IL-17、TNF-α、RANKL水平均降低，观察组低于对照组（P＜0.05）；治疗后PaCO2水平降低，SaO2、PaO2水平升高，观察组与对照组比较有相同趋势（P＜0.05）；治疗后两组患者GQOLI-74相关维度评分均升高，观察组与对照组比较有差异（P＜0.05）。结论：对慢性阻塞性肺疾病稳定期患者在常规治疗基础上增加肠道益生菌联合健身气功八段锦治疗效果显著，可改善患者肺功能、运动耐力，减轻疾病严重程度，且能够降低患者炎症因子及RANKL水平，改善血气指标，提升患者生活质量。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the efficacy of intestinal probiotics combined with health Qigong in patients with chronic obstructive lung (disease) and its effect on nuclear factor κB receptor activation factor ligand (RANKL) and blood gas index. Methods: 88 stable patients with COPD from January 2018 to December 2023 were selected. They were divided into an observation group and a matched group, with 44 cases in each group. The matched group patients were treated with conventional Western medicine, while the observation group was treated with intestinal probiotics combined with fitness Qigong Eight Section Brocade in addition to the matched group. Pulmonary function, 6-minute walking test (6MWT), and Chronic Obstructive Pulmonary Disease Assessment Scale (CAT) were used to evaluate the therapeutic effect of the two groups of patients. Inflammatory response indicators and RANKL levels were compared before and Post-treatment, and blood gas indicators and quality of life were compared between the two groups of patients. Results: FEV1, FVC, FEV1 / FVC, and 6 MWT were increased in both groups post-treatment, A ed CAT score. The same trend was observed between the observation group and the matched group (P<0.05); Post-treatment, IL-17, TNF-α, and RANKL levels were reduced in both groups, The observation group was lower than the matched group (P<0.05); Lower PaCO2 levels Post-treatment, Increased levels of SaO2 and PaO2, The observation group followed the matched group (P<0.05); GQOLI-74 related dimension scores were elevated in both groups Post-treatment. Different compared from the matched group (P<0.05). Conclusion: The combination of intestinal probiotics and fitness qigong Baduanjin has a significant therapeutic effect on stable patients with chronic obstructive pulmonary disease in addition to conventional treatment. It can improve lung function, exercise endurance, alleviate disease severity, reduce inflammatory factors and RANKL levels, improve blood gas indicators, and enhance patient quality of life. |
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