| 杨 凯,江成功,宋和鉴,尹德录.左西孟旦对急性心肌梗死患者PCI治疗后心肌灌注和心电图指标的影响[J].,2024,(13):2542-2545 |
| 左西孟旦对急性心肌梗死患者PCI治疗后心肌灌注和心电图指标的影响 |
| Effects of Levosimendan on Myocardial Perfusion and Electrocardiogram Indexes in Patients with Acute Myocardial Infarction after PCI |
| 投稿时间：2024-01-23 修订日期：2024-02-18 |
| DOI：10.13241/j.cnki.pmb.2024.13.027 |
| 中文关键词: 左西孟旦 氯吡格雷 急性心肌梗死 经皮冠状动脉介入 心肌灌注 心电图指标 |
| 英文关键词: Levosimendan Clopidogrel Acute myocardial infarction Percutaneous coronary intervention Myocardial perfusion Electrocardiogram index |
| 基金项目:江苏省卫生健康委2020年度医学科研项目（ZDB2020029） |
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| 中文摘要: |
| 摘要 目的：探讨左西孟旦对急性心肌梗死患者经皮冠状动脉介入（PCI）治疗后心肌灌注和心电图指标的影响。方法：选择2020年1月至2022年12月在我院接受治疗的113例急性心肌梗死患者PCI治疗患者，采用随机数表法分为试验组（n=57）和对照组（n=56）。对照组给予PCI治疗后氯吡格雷治疗，试验组加用左西孟旦治疗。比较两组临床疗效、心肌灌注分级、2 h内ST段回落幅度、Tp-e/QT、CI、LVEF、LVESD、LVEDD及并发症发生情况。结果：试验组治疗总有效率89.13%，较对照组71.11%高，（P<0.05）；治疗后，两组心肌灌注分级水平均升高，试验组升高更为明显（P<0.05）；试验组2 h内ST段回落幅度良好较对照组高（P<0.05），治疗后，两组Tp-e/QT水平均降低，试验组降低更为明显（P<0.05）；治疗后，两组CI、LVEF水平均升高，试验组升高更为明显（P<0.05），两组LVESD、LVEDD水平均降低，试验组降低更为明显（P<0.05）；治疗期间，不良反应主要有恶心、发热、再发心绞痛及心律失常，两组发生率比较（P>0.05）。结论：在急性心肌梗死患者PCI治疗中左西孟旦治疗有较好的效果，可有效改善患者心肌灌注和心电图指标水平。 |
| 英文摘要: |
| ABSTRACT Objective: To study Effects of levosimendan on myocardial perfusion and electrocardiogram indexes in patients with acute myocardial infarction after Percutaneous coronary intervention (PCI). Methods: 113 patients with acute myocardial infarction who received PCI treatment in our hospital from January 2020 to December 2022 were selected and divided into experimental group (n=57) and control group (n=56) by random number table method. The control group was treated with clopidogrel after PCI, and the experimental group was treated with levosimendan. The clinical efficacy, myocardial perfusion grade, ST segment retreat within 2 h, Tp-e/QT, CI, LVEF, LVESD, LVEDD and the incidence of complications were compared between the two groups. Results: The total effective rate of the experimental group was 89.13%, higher than that of the control group 71.11%(P<0.05). After treatment, the myocardial perfusion grade level of both groups was increased, and the increase of experimental group was more obvious(P<0.05). The ST segment in test group was better than that in control group within 2 h(P<0.05). After treatment, the Tp-e/QT level in both groups was decreased, and the decrease in test group was more obvious (P<0.05). After treatment, CI and LVEF levels were increased in both groups, more significantly in experimental group(P<0.05); LVESD and LVEDD levels were decreased in both groups, more significantly in experimental group (P<0.05); During treatment, the main adverse reactions were nausea, fever, recurrent angina pectoris and arrhythmia, and the incidence rate was compared between the two groups (P>0.05). Conclusion: Levosimendan has a good effect in PCI treatment of patients with acute myocardial infarction, which can effectively improve the level of myocardial perfusion and electrocardiogram. |
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