| 曾春梅,邓 斌,白 莹,李颖媛,梁光丽.房水Sema3A、Klotho、SDF-1与增生型糖尿病视网膜病变患者术后新生血管性青光眼的关系研究[J].,2024,(12):2356-2360 |
| 房水Sema3A、Klotho、SDF-1与增生型糖尿病视网膜病变患者术后新生血管性青光眼的关系研究 |
| Study on the Relationship between Aqueous Humor Sema3A, Klotho, SDF-1 and Postoperative Neovascular Glaucoma in Patients with Proliferative Diabetic Retinopathy |
| 投稿时间：2023-11-06 修订日期：2023-11-28 |
| DOI：10.13241/j.cnki.pmb.2024.12.031 |
| 中文关键词: 增生型糖尿病视网膜病变 Sema3A Klotho SDF-1 新生血管性青光眼 |
| 英文关键词: Proliferative diabetic retinopathy Sema3A Klotho SDF-1 Neovascular glaucoma |
| 基金项目:四川省卫生厅科研基金项目（1931392） |
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| 中文摘要: |
| 摘要 目的：探讨房水信号素3A（Sema3A）、克洛索（Klotho）、基质细胞衍生因子-1（SDF-1）与增生型糖尿病视网膜病变（PDR）患者术后新生血管性青光眼（NVG）的关系。方法：选取2021年1月～2022年1月成都市第六人民医院收治的145例接受玻璃体切割术PDR患者，根据术后1年是否发生NVG分为NVG组和非NVG组。酶联免疫吸附法检测房水Sema3A、Klotho、SDF-1水平。采用多因素Logistic回归分析影响PDR患者术后NVG的因素，受试者工作特征（ROC）曲线分析房水Sema3A、Klotho、SDF-1对PDR患者术后NVG的预测价值。结果：PDR患者随访1年，术后NVG发生率为17.24%。与非NVG组比较，NVG组房水Sema3A、SDF-1水平升高，Klotho水平降低（P＜0.05）。多因素Logistic回归分析显示，术前虹膜新生血管和Sema3A、SDF-1升高为影响PDR患者术后NVG的独立危险因素，Klotho升高为独立保护因素（P＜0.05）。ROC曲线分析显示，房水Sema3A、Klotho、SDF-1联合预测PDR患者术后NVG的曲线下面积（AUC）为0.913，大于房水Sema3A、Klotho、SDF-1单独预测的0.796、0.794、0.800。结论：房水Sema3A、SDF-1升高和Klotho降低与PDR患者术后NVG发生密切相关，房水Sema3A、Klotho、SDF-1联合检测对PDR患者术后NVG具有较高的预测价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between aqueous humor semaphorin-3A (Sema3A), Klotho, stromal cell-derived factor-1 (SDF-1) and postoperative neovascular glaucoma (NVG) in patients with proliferative diabetic retinopathy (PDR). Methods: 145 patients admitted to Chengdu Sixth People's Hospital from January 2021 to January 2022 who underwent vitrectomy PDR were selected, and according to whether occurrence of NVG at 1 year after surgery, patients were divided into the NVG group and the non-NVG group. Enzyme-linked immunosorbent assay was used to detect the levels of aqueous humor Sema3A, Klotho and SDF-1. Multivariate Logistic regression analysis was used to analyze the factors affecting postoperative NVG in patients with PDR, and the predictive value of aqueous humor Sema3A, Klotho and SDF-1 on postoperative NVG in patients with PDR was analyzed by receiver operating characteristic (ROC) curve. Results: PDR patients were followed up for 1 year, and the incidence rate of postoperative NVG was 17.24%.Compared with the non-NVG group, the levels of aqueous humor Sema3A and SDF-1 in the NVG group were increased, and the level of Klotho was decreased(P＜0.05). Multivariate Logistic regression analysis showed that preoperative iris neovascularization and elevated Sema3A and SDF-1 were independent risk factors affecting postoperative NVG in patients with PDR, and elevated Klotho was an independent protective factor(P＜0.05). ROC curve analysis showed that the area under curve (AUC) of aqueous humor Sema3A, Klotho and SDF-1 predicted postoperative NVG in patients with PDR was 0.913, which was greater than the 0.796, 0.794, and 0.800 predicted by aqueous humor Sema3A, Klotho and SDF-1 individually. Conclusion: Elevated aqueous humor Sema3A, SDF-1 and reduced Klotho are closely related to the occurrence of postoperative NVG in patients with PDR, and the combined detection of aqueous humor Sema3A, Klotho and SDF-1 has a high predictive value for postoperative NVG in patients with PDR. |
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