| 玛衣努尔·艾赛提,马依热·阿布都赛麦提,热孜亚·艾尼,张 淼,苏 旭.浓缩自体生长因子对牙周组织再生术用于重度牙周炎患者疗效，牙龈厚度和免疫因子水平影响分析[J].,2024,(12):2288-2292 |
| 浓缩自体生长因子对牙周组织再生术用于重度牙周炎患者疗效，牙龈厚度和免疫因子水平影响分析 |
| Analysis of the Effects of Concentrated Autologous Growth Factor on the Efficacy, Gingival Thickness, and Immune Factor Levels of Periodontal Tissue Regeneration Surgery in Patients with Severe Periodontitis |
| 投稿时间：2023-11-05 修订日期：2023-11-28 |
| DOI：10.13241/j.cnki.pmb.2024.12.016 |
| 中文关键词: 浓缩自体生长因子 牙周组织再生术 重度牙周炎 临床疗效 |
| 英文关键词: Concentrated autologous growth factor Periodontal tissue regeneration surgery Severe periodontitis Clinical efficacy |
| 基金项目:新疆维吾尔自治区2021年度面上基金项目（2021D01C161） |
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| 中文摘要: |
| 摘要 目的：探讨浓缩自体生长因子联合牙周组织再生术对重度牙周炎患者疗效，牙龈厚度和免疫因子水平影响。方法：选取我院2019年6月至2020年6月收治的58例重度牙周炎患者，分为对照组和观察组，各29例。对照组接受牙周组织再生术；观察组接受牙周组织再生术联合浓缩自体生长因子治疗。分别在治疗前、治疗9个月后复诊，对比两组患者临床疗效，治疗前后牙龈厚度、视觉模拟量表（VAS）评分，治疗前后龈沟液及血清白细胞介素-17（IL-17）、白细胞介素-23（interleukin-17，IL-23）、白细胞介素-17（IL-23）表达水平。结果：与对照组相比，观察组总有效率高（P<0.05）；治疗前，两组患者牙龈厚度、VAS评分对比无差异（P＞0.05），治疗后两组患者牙龈厚度增加，观察组高于对照组，VAS评分降低，观察组低于对照组（P＜0.05）；治疗前，两组患者龈沟液IL-17、IL-23、IL-10对比无差异（P＞0.05），治疗后，两组患者龈沟液因子表达有差异，观察组较对照组有差异（P＜0.05）；治疗前，两组患者血清IL-17、IL-23、IL-10对比无差异（P＞0.05），治疗后，两组患者血清因子表达有差异，观察组较对照组有差异（P＜0.05）。结论：浓缩自体生长因子联合牙周组织再生术可对重度牙周炎治疗效果显著，可增加患者牙龈厚度，减轻疼痛程度，改善龈沟液及血清中免疫因子水平，减轻炎症反应，值得临床应用推广。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the therapeutic effect of concentrated autologous growth factor combined with periodontal tissue regeneration on patients with severe periodontitis, as well as the effects of gingival thickness and immune factor levels. Methods: A prospective study was conducted on 58 patients with severe periodontitis admitted to our hospital from June 2019 to June 2020. They were divided into a matched group and an observation group using a random number table method, with 29 patients in each group. The matched group received periodontal tissue regeneration surgery; The observation group received periodontal tissue regeneration surgery combined with concentrated autologous growth factor treatment. Prior to treatment and 9 months Post-treatment, follow-up visits were conducted to compare the clinical efficacy of the two groups of patients, including gingival thickness, visual analog scale (VAS) scores, and the expression levels of interleukin-17(IL-17), interleukin-23(IL-23), and interleukin-17(IL-23) in gingival crevicular fluid and serum before and Post-treatment. Results: The total effective rate of 93.10% in the observation group was higher than 72.41% in the matched group(P<0.05); Pretherapy, there was no difference in gingival thickness and VAS score between the two groups of patients (P>0.05). Post-treatment, the gingival thickness of the two groups of patients increased, and the observation group was higher than the matched group, while the VAS score decreased. The observation group was lower than the matched group (P<0.05); Pretherapy, there was no difference in the comparison of gingival crevicular fluid IL-17, IL-23, and IL-10 between the two groups(P>0.05). Post-treatment, the expression of gingival crevicular fluid factor was different between the two groups of patients, and the observation group was different compared with the matched group(P<0.05); Pretherapy, there was no difference in serum IL-17, IL-23, and IL-10 comparison (P>0.05). Post-treatment, the serum factor expression between the two groups was different, and the observation group was different compared with the matched group(P<0.05). Conclusion: The combination of concentrated autologous growth factor and periodontal tissue regeneration has a significant therapeutic effect on severe periodontitis. It can increase the thickness of the patient's gingiva, reduce pain, improve the levels of immune factors in gingival crevicular fluid and serum, and reduce inflammatory reactions. It is worthy of clinical application and promotion. |
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