| 龙 燕,刘 格,黄学阳,林鸿国,周榆腾,刘大晟.甲状腺乳头状癌组织YAP、SATB1、ROR2与临床病理特征和复发的关系研究[J].,2024,(11):2088-2093 |
| 甲状腺乳头状癌组织YAP、SATB1、ROR2与临床病理特征和复发的关系研究 |
| Study on the Relationship between YAP, SATB1, ROR2 of Papillary Thyroid Carcinoma Tissues and Clinicopathological Features and Recurrence |
| 投稿时间：2024-01-27 修订日期：2024-02-23 |
| DOI：10.13241/j.cnki.pmb.2024.11.016 |
| 中文关键词: 甲状腺乳头状癌 YAP SATB1 ROR2 临床病理特征 复发 |
| 英文关键词: Papillary thyroid carcinoma YAP SATB1 ROR2 Clinicopathological features Recurrence |
| 基金项目:广东省中医药局科研项目（20191147）；广东省中医药局科研项目（20232033） |
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| 中文摘要: |
| 摘要 目的：探讨甲状腺乳头状癌组织Yes相关蛋白（YAP）、核基质结合区结合蛋白1（SATB1）、受体酪氨酸激酶样孤儿素受体2（ROR2）与临床病理特征和复发的关系。方法：选择2019年6月至2021年6月广东省中医院收治的198例行手术治疗的甲状腺乳头状癌患者，取手术切除的癌组织和癌旁组织，免疫组化法检测YAP、SATB1、ROR2蛋白表达情况。术后随访2年，统计复发情况，根据复发情况将患者分为复发组和未复发组。比较甲状腺乳头状癌患者不同临床病理特征之间YAP、SATB1、ROR2蛋白表达差异，多因素Cox回归分析影响甲状腺乳头状癌术后复发的因素。结果：癌组织中YAP、SATB1、ROR2阳性表达率高于癌旁组织（P＜0.05）。低度分化、TNM分期Ⅲ期、淋巴结转移患者癌组织中YAP、SATB1、ROR2阳性表达率高于中高度分化、TNM分期Ⅰ～Ⅱ期、无淋巴结转移患者（P＜0.05）。198例患者随访2年失访1例，复发21例，复发率为10.66%。复发组癌组织中YAP、SATB1、ROR2阳性表达率高于未复发组癌组织（P＜0.05）。多因素Cox回归分析显示低分化、TNM分期Ⅲ期、未淋巴结清扫、YAP阳性表达、SATB1阳性表达、ROR2阳性表达比是甲状腺乳头状癌术后复发的危险因素（P＜0.05）。结论：甲状腺乳头状癌组织中YAP、SATB1、ROR2阳性表达率显著增高，YAP、SATB1、ROR2阳性表达与低分化、淋巴结转移、晚TNM分期以及术后复发有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between Yes-associated protein (YAP), nuclear matrix binding region binding protein 1 (SATB1), receptor tyrosine kinase-like orphanin receptor 2 (ROR2) of papillary thyroid carcinoma tissues and clinicopathological features and recurrence. Methods: 198 patients with papillary thyroid carcinoma who underwent surgical treatment in Guangdong Provincial Hospital of Chinese Medicine from June 2019 to June 2021 were selected, the resected cancer tissues and adjacent tissues were taken, and the expression of YAP, SATB1 and ROR2 proteins was detected by immunohistochemistry. After 2 years of follow-up, the recurrence was counted, and the patients were divided into recurrence group and non-recurrence group according to the recurrence. The differences of YAP, SATB1 and ROR2 protein expression between different clinicopathological features of papillary thyroid carcinoma were compared, the factors affecting postoperative recurrence of papillary thyroid carcinoma were analyzed by multivariate Cox regression analysis. Results: The positive expression rates of YAP, SATB1 and ROR2 in cancer tissues were higher than those in adjacent tissues (P<0.05). The positive expression rates of YAP, SATB1 and ROR2 in cancer tissues of patients with low differentiation, TNM stage III and lymph node metastasis were higher than those in patients with moderate to high differentiation, TNM stage I～II and no lymph node metastasis (P<0.05). 198 patients were followed up for 2 years, 1 case was lost to follow-up, 21 cases recurred, and the recurrence rate was 10.66%. The positive expression rates of YAP, SATB1 and ROR2 in recurrence group were higher than those in the non-recurrence group (P<0.05). Multivariate Cox regression analysis showed that low differentiation, TNM stage III, no lymph node cleaning, YAP positive expression, SATB1 positive expression, and ROR2 positive expression were risk factors for postoperative recurrence of papillary thyroid carcinoma (P<0.05). Conclusion: The positive expression rates of YAP, SATB1 and ROR2 in papillary thyroid carcinoma are significantly increase, the positive expression of YAP, SATB1 and ROR2 are relate to low differentiation, lymph node metastasis, late TNM stage and postoperative recurrence. |
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