| 常 燕,梁瑞丽,王 欢,王丽娜,杨玉蛟.酸枣仁汤合百合地黄汤加减联合针刺对脑卒中后阴虚火旺型失眠患者睡眠质量及血清神经递质水平的影响[J].,2024,(10):1888-1891 |
| 酸枣仁汤合百合地黄汤加减联合针刺对脑卒中后阴虚火旺型失眠患者睡眠质量及血清神经递质水平的影响 |
| Effect of Sour Jujube Kernel Decoction Combined with Lily Dihuang Decoction Plus Minus Combined with Acupuncture on Sleep Quality and Serum Neurotransmitter Levels in Patients with Yin Deficiency Insomnia after Stroke |
| 投稿时间：2023-10-06 修订日期：2023-10-28 |
| DOI：10.13241/j.cnki.pmb.2024.10.018 |
| 中文关键词: 酸枣仁汤合百合地黄汤 针刺 脑卒中 阴虚火旺型失眠 睡眠质量 神经递质 |
| 英文关键词: Sour jujube kernel soup and lily dihuang soup Acupuncture Stroke Yin deficiency and fire type insomnia Sleep quality Neurotransmitter |
| 基金项目:北京市属医院科研培育计划项目（PZ2019019） |
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| 中文摘要: |
| 摘要 目的：观察酸枣仁汤合百合地黄汤加减联合针刺对脑卒中后阴虚火旺型失眠患者睡眠质量及血清神经递质水平的影响。方法：所选病例均来自于我院2018年3月~2023年2月期间收治的脑卒中后阴虚火旺型失眠患者，共计126例。按照随机数字表法将患者分为对照组（常规西医治疗+针刺治疗，63例）和观察组（对照组的基础上接受酸枣仁汤合百合地黄汤加减治疗，63例）。对比两组疗效、中医证候积分、量表评分[匹兹堡睡眠质量指数量表（PSQI）、睡眠状况自评量表（SRSS）]、血清神经递质[5-羟色胺（5-HT）和多巴胺（DA）]。结果：观察组的临床总有效率高于对照组，比较有统计学差异（P<0.05）。两组治疗后入睡困难、易醒早醒、心悸易惊、手足心热、头晕耳鸣、口干咽燥评分下降，且观察组低于对照组，比较均有统计学差异（P<0.05）。两组治疗后PSQI评分、SRSS评分下降，且观察组低于对照组，比较均有统计学差异（P<0.05）。两组治疗后DA下降，5-HT升高，且观察组的改善幅度大于对照组，比较均有统计学差异（P<0.05）。结论：酸枣仁汤合百合地黄汤加减联合针刺治疗脑卒中后阴虚火旺型失眠，可有效改善失眠症状，调节血清5-HT、DA水平。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effect of sour jujube kernel decoction combined with lily dihuang decoction plus minus combined with acupuncture on sleep quality and serum neurotransmitter levels in patients with yin deficiency insomnia after stroke. Methods: The selected cases were all from patients with insomnia after stroke admitted to our hospital during March 2018 to February 2023, a total of 126 cases. According to the random number table method, the patients were divided into control group (conventional Western medicine treatment + acupuncture treatment, 63 cases) and observation group (63 cases received plus and minus treatment on the basis of sour jujube kernel soup and lily dihuang decoction, 63 cases). The efficacy, TCM syndrome scores, and scale scores [Pittsburgh Sleep Quality Index Scale (PSQI), Sleep Status Self-rating Scale (SRSS)], and serum neurotransmitters [serotonin (5-HT) and dopamine (DA) were compared between the two groups. Results: The total clinical effective rate of the observation group was higher than that of the control group, which showed statistical difference(P<0.05). After the treatment, the scores of the two groups were lower than those in the control group, which showed statistical difference(P<0.05). After treatment, PSQI score and SRSS score decreased in the two groups, and the observation group was lower than that in the control group, which showed statistical difference(P<0.05). After the treatment of the two groups, DA decreased and 5-HT increased, and the improvement in the observation group was greater than that in the control group, which showed statistical difference(P<0.05). Conclusion: The combination of sour jujube kernel decoction and lily dihuang decoction plus minus combined with acupuncture in the treatment of yin deficiency and fire type insomnia after stroke can effectively improve insomnia symptoms and regulate serum 5-HT and DA levels. |
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