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| 龈沟液Galectin-3、LCN2、Sema3A水平与慢性牙周炎患者牙周指标及病情严重程度的关系研究 |
| Relationship Between Galectin-3, LCN2, Sema3A levels in Gingival Crevicular Fluid and Periodontal Indexes and Disease Severity of Chronic Periodontitis Patients |
| 投稿时间：2024-09-10 修订日期：2024-09-10 |
| DOI： |
| 中文关键词: 龈沟液 半乳糖凝聚素-3 脂质运载蛋白2 脑信号蛋白3A 慢性牙周炎 牙周指标 病情程度 |
| 英文关键词: Gingival crevicular fluid Galactocondensin-3 Lipid-carrying protein 2 Semaphorin 3A Chronic periodontitis Periodontal indexes Disease severity |
| 基金项目:陕西省2023年科技计划项目（2023-JC-QN-0997） |
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| 中文摘要: |
| 目的：探讨龈沟液（GCF）半乳糖凝聚素-3（Galectin-3）、脂质运载蛋白2（LCN2）、脑信号蛋白3A（Sema3A）水平与慢性牙周炎患者牙周指标及病情严重程度的关系。方法：选取2021年7月~2023年7月期间我院牙周病科收治的慢性牙周炎患者142例纳入观察组，另选取同期于我院牙周病科复诊的健康志愿者90例纳入对照组。比较对照组、观察组GCF Galectin-3、LCN2、Sema3A水平。慢性牙周炎患者根据病情严重程度分为轻中度牙周炎组（n=83）、重度牙周炎组（n=59）。比较轻中度牙周炎组、重度牙周炎组GCF Galectin-3、LCN2、Sema3A水平和牙周指标。采用Pearson相关性检验分析GCF Galectin-3、LCN2、Sema3A水平与牙周指标的相关性。采用受试者工作特征（ROC）曲线分析GCF Galectin-3、LCN2、Sema3A单一及联合检测对慢性牙周炎的诊断价值。结果：观察组GCF Galectin-3、LCN2水平高于对照组，GCF Sema3A水平低于对照组（P＜0.05）。重度牙周炎组GCF Galectin-3、LCN2水平、牙龈指数（GI）、牙周袋深度（PD）、附着丧失（AL）高于轻中度牙周炎组，GCF Sema3A水平低于轻中度牙周炎组（P＜0.05）。GCF Galectin-3、LCN2水平与GI、PD、AL呈正相关，GCF Sema3A水平与GI、PD、AL呈负相关（P＜0.05）。GCF Galectin-3、LCN2、Sema3A单一及联合检测诊断慢性牙周炎的曲线下面积（AUC）分别为0.707（0.439~0.976）、0.725（0.433~0.989）、0.760（0.573~0.925）、0.868（0.788~0.921），且联合检测的诊断效能显著高于三指标单一检测。结论：慢性牙周炎患者GCF Galectin-3、LCN2水平升高，Sema3A水平降低，与牙周指标及病情程度加重有关，三指标联合检测对慢性牙周炎具有较高的诊断价值。 |
| 英文摘要: |
| Objective:To investigate the relationship between the Galactocondensin-3 (Galectin-3), Lipid-carrying protein 2 (LCN2), Semaphorin 3A (Sema3A) levels in gingival crevicular fluid (GCF) and periodontal indexes and disease severity of chronic periodontitis patients. Methods:142 chronic periodontitis patients who were admitted to periodontology department of our hospital from July 2021 to July 2023 were selected as the observation group,and 90 healthy volunteers who were revisited in the periodontal department of our hospital during the same period were included as the control group. The Galectin-3, LCN2 and Sema3A levels in GCF were compared between control group and observation group. Chronic periodontitis patients were divided into mild to moderate periodontitis group (n=83) and severe periodontitis group (n=59) according to the disease severity. The Galectin-3, LCN2, Sema3A levels in GCF and periodontal indexes were compared between mild to moderate periodontitis group and severe periodontitis group. The correlation between Galectin-3, LCN2, Sema3A levels in GCF and periodontal indexes were analyzed by Pearson correlation test. The diagnostic value of single and combined detection of Galectin-3, LCN2 and Sema3A in GCF for chronic periodontitis were analyzed by receiver operating characteristic (ROC) curve.Results:The Galectin-3 and LCN2 levels in GCF in observation group were higher than those in control group, and the Sema3A level in GCF was lower than that in control group (P<0.05). The Galectin-3, LCN2 levels in GCF, gingival index (GI), periodontal pocket depth (PD) and attachment loss (AL) in severe periodontitis group were higher than those in mild to moderate periodontitis group, and the Sema3A level in GCF was lower than that in mild to moderate periodontitis group (P<0.05). The Galectin-3 and LCN2 levels in GCF were positively correlated with GI, PD and AL, and the Sema3A level in GCF was negatively correlated with GI, PD and AL (P<0.05). The area under the curve (AUC) of single and combined detection of Galectin-3, LCN2 and Sema3A in GCF for the diagnosis of chronic periodontitis were 0.707 (0.439~0.976 ), 0.725 (0.433~0.989), 0.760 (0.573~0.925) and 0.868 (0.788~0.921), respectively, and the diagnostic efficacy of combined detection was significantly higher than that of single detection in three indexes. Conclusion: The Galectin-3 and LCN2 levels in GCF of chronic periodontitis patients are increased, and the Sema3A level is decreased, which are related to periodontal indexes and disease severity, the combined detection in three indexes has a high diagnostic value for chronic periodontitis. |
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