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| 急性ST段抬高型心肌梗死患者血清FIB、TG/HDL-C比值、MPV/PC比值与院内新发心房颤动的关系研究 |
| Study on the Relationship Between Serum FIB, TG/HDL-C Ratio,MPV/PC Ratio and New-Onset Atrial Fibrillation in Patients With Acute ST-Segment Elevation Myocardial Infarction |
| 投稿时间：2024-09-09 修订日期：2024-09-09 |
| DOI： |
| 中文关键词: 急性ST段抬高型心肌梗死 FIB TG/HDL-C比值 MPV/PC比值 新发心房颤动 预测价值 |
| 英文关键词: Acute ST-segment elevation myocardial infarction FIB TG/HDL-C ratio MPV/PC ratio New-onset atrial fibrillation Predictive value |
| 基金项目:山东省医药卫生科技发展计划项目（202003011333） |
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| 中文摘要: |
| 目的 探讨急性ST段抬高型心肌梗死（ASTEMI）患者血清纤维蛋白原（FIB）、三酰甘油/高密度脂蛋白胆固醇（TG/HDL-C）比值、平均血小板体积/血小板计数（MPV/PC）比值与院内新发心房颤动（NOAF）的关系。方法 选取2021年2月～2024年3月我院收治的274例ASTEMI患者，根据患者院内是否发生NOAF将其分为NOAF组（41例）和非NOAF组（233例），检测并对比两组FIB、TG/HDL-C比值、MPV/PC比值。采用多因素Logistic回归分析ASTEMI患者院内发生NOAF的影响因素，采用受试者工作特征（ROC）曲线评估血清FIB、TG/HDL-C比值、MPV/PC比值单独及联合预测ASTEMI患者院内发生NOAF的价值。结果 NOAF组血清FIB、TG/HDL-C比值、MPV/PC比值高于非NOAF组（P＜0.05）。NOAF组Killip分级≥Ⅱ级比例高于非NOAF组（P＜0.05）。Killip分级≥Ⅱ级、血清FIB、TG/HDL-C比值、MPV/PC比值均升高是ASTEMI患者院内发生NOAF的独立危险因素。血清FIB、TG/HDL-C比值、MPV/PC比值单独及联合预测ASTEMI患者院内发生NOAF的曲线下面积（AUC）分别为0.771、0.795、0.792、0.895。结论 ASTEMI患者血清FIB、TG/HDL-C比值、MPV/PC比值均升高，是患者院内发生NOAF的危险因素，三指标联合检测预测ASTEMI患者院内发生NOAF的效能较高。 |
| 英文摘要: |
| Objective To investigate the relationship between serum fibrinogen (FIB), triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio, mean platelet volume/platelet count (MPV/PC) ratio and in-hospital new-onset atrial fibrillation (NOAF) in patients with acute ST-segment elevation myocardial infarction (ASTEMI). Methods 274 ASTEMI patients admitted to our hospital from February 2021 to March 2024 were selected, and patients were divided into NOAF group (41 cases) and Non NOAF group (233 cases) according to whether NOAF occurred in the hospital, FIB, TG/HDL-C ratio and MPV/PC ratio were detected and compared in two groups. The influencing factors of in-hospital NOAF in ASTEMI patients were analyzed by multivariate Logistic regression, the value of serum FIB, TG/HDL-C ratio, MPV/PC ratio alone and in combination in predicting in-hospital NOAF in ASTEMI patients were evaluated by receiver operating characteristic (ROC) curve. Results The serum FIB, TG/HDL-C ratio and MPV/PC ratio in NOAF group were higher than those in Non NOAF group (P<0.05). The proportion of Killip grade≥II in NOAF group was higher than that in Non NOAF group (P<0.05). Killip grade≥II, elevated serum FIB, TG/HDL-C ratio, and MPV/PC ratio were independent risk factors for NOAF in ASTEMI patients. The area under the curve (AUC) of serum FIB, TG/HDL-C ratio and MPV/PC ratio alone and in combination for predicting NOAF in ASTEMI patients were 0.771, 0.795, 0.792 and 0.895, respectively. Conclusion The serum FIB, TG/HDL-C ratio and MPV/PC ratio of ASTEMI patients are increased, which are the risk factors of NOAF in patients, the combined detection of the three indexes is more effective in predicting the occurrence of NOAF in ASTEMI patients. |
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