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| 四妙散加味联合抗生素对盆腔炎性疾病后遗症患者NF-κB信号通路相关指标的影响 |
| Effect of Modified Simiao Jiawei Powder Combined With Antibiotics on NF-κB Signaling Pathway Related Indicators in Sequelae of Pelvic Inflammatory Disease Patients |
| 投稿时间：2024-09-09 修订日期：2024-09-09 |
| DOI： |
| 中文关键词: 四妙散加味 抗生素 盆腔炎性疾病后遗症 核转录因子-κB信号通路 |
| 英文关键词: Simiao jiawei powder Antibiotics Sequela of pelvic inflammatory disease Nuclear factor-κB signaling pathway |
| 基金项目:广东省中医药局科研项目（20211417） |
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| 中文摘要: |
| 目的：观察四妙散加味联合抗生素对盆腔炎性疾病后遗症（SPID）患者核转录因子-κB（NF-κB）信号通路相关指标的影响。方法：按照随机数字表法将我院2020年3月~2023年4月期间收治的142例湿热瘀结型SPID患者分为对照组（接受抗生素治疗，n=71）和研究组（接受四妙散加味联合抗生素治疗，n=71）。对比两组治疗前后中医证候积分，子宫血流动力学指标，盆腔积液、炎性包块、宫颈分泌物情况以及血清NF-κB信号通路相关指标。结果：研究组治疗后中医证候积分、阻力指数（RI）、搏动指数（PI）低于对照组；子宫动脉收缩期峰值流速（PSV）高于对照组（P<0.05）。研究组治疗后炎性包块大小、盆腔积液深度、宫颈分泌物阳性例数改善效果优于对照组（P<0.05）。研究组治疗后血清NF-κB/P50、NF-κB/P65水平低于对照组（P<0.05）。结论：四妙散加味联合抗生素治疗SPID患者，能有效改善临床症状及子宫血流动力学，可能与其抑制NF-κB信号通路激活有关。 |
| 英文摘要: |
| Objective:To observe the effect of modified simiao powder combined with antibiotics on the nuclear factor-κB (NF-κB) signaling pathway related indicators in sequelae of pelvic inflammatory disease (SPID) patients. Methods:142 damp-heat stasis type SPID patients admitted to our hospital from March 2020 to April 2023 were divided into control group (treated with antibiotics, n=71) and study group (treated with modified simiao powder combined with antibiotics, n=71) by using a random number table method.The traditional chinese medicine syndrome points, uterine hemodynamic indexes, pelvic effusion, inflammatory mass, cervical secretions and serum NF-κB signaling pathway related indexes before and after treatment were compared between the two groups. Results:The traditional chinese medicine syndrome points, resistance index (RI) and pulsatility index (PI) in study group were lower than those in control group after treatment. And the peak systolic velocity (PSV) of uterine artery was higher than that in control group (P<0.05). The improvement effect of inflammatory mass size, pelvic effusion depth and cervical secretion positive cases in study group were better than those in control group after treatment (P<0.05). Serum NF-κB/P50 and NF-κB/P65 in study group were lower than those in control group after treatment (P<0.05).Conclusion:Simiao jiawei powder combined with antibiotics in the treatment of SPID patients, can effectively improve the clinical symptoms and uterine hemodynamics, which may be related to the inhibition of NF-κB signaling pathway activation. |
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