| 伍咏瑶,高平明,罗威耀,万瑞平,梁伟怡,周绮娴.2018-2022年佛山地区小儿沙门氏菌感染的临床特征和耐药性分析[J].,2024,(9):1653-1657 |
| 2018-2022年佛山地区小儿沙门氏菌感染的临床特征和耐药性分析 |
| Clinical Characteristics and Drug Resistance Analysis of Salmonella Infection in Children in Foshan Area From 2018 to 2022 |
| 投稿时间：2024-01-08 修订日期：2024-01-28 |
| DOI：10.13241/j.cnki.pmb.2024.09.010 |
| 中文关键词: 佛山 沙门氏菌感染 儿童 临床特征 耐药性 |
| 英文关键词: Foshan Salmonella infection Children Clinical features Drug resistance |
| 基金项目:广东省基础与应用基础研究基金联合基金项目-青年基金项目（2020A1515110095） |
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| 中文摘要: |
| 摘要 目的：分析2018-2022年佛山地区小儿沙门氏菌感染的临床特征和耐药性，为小儿沙门氏菌感染的临床防治提供依据。方法：对2018年1月1日至2022年12月31日期间佛山市妇幼保健院收集的小儿沙门氏菌感染病例186例进行回顾性分析，分析患儿一般资料、小儿沙门氏菌感染的时间分布特征、临床特征、血清型分布及耐药性。结果：186例小儿沙门氏菌感染患儿年龄分布，1~3岁构成比最高，占37.63%，>6岁构成比最低，占1.61%。2018年发病33例，2019年发病19例，2020年发病39例，2021年发病44例，2022年发病51例，沙门氏菌感染病例数总体呈现上升趋势；一年四季均有沙门氏菌感染病例，夏秋两季发病率最高，分别占43.55%、30.11%。发热、腹泻、解粘液便为主要症状，分别占90.32%、74.73%和63.98%。血清型B群最高，为118例，占63.44%。通过对分离出的191株沙门氏菌药物敏感性试验分析，只有3株（1.57%）对所检测抗菌药物均不耐药，耐3类或3类以上的多重耐药沙门氏菌有157株（82.20%），庆大霉素、头孢唑啉、头孢替坦耐药率均为100%。不同年份沙门氏菌对左氧氟沙星、环丙沙星、四环素的耐药率差异有统计学意义（P<0.05）。结论：近年来佛山地区小儿沙门氏菌感染呈上升趋势，1~3岁儿童是主要群体，夏季和秋季是发病的高峰季节，主要血清型是B群，儿童感染后以发热、腹泻、解粘液便为主要症状，沙门氏菌的耐药性较为严重，应引起相关部门重视。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the clinical characteristics and drug resistance of Salmonella infection in children in Foshan area from 2018 to 2022, and provide a basis for the clinical prevention and treatment of Salmonella infection. Methods: A retrospective analysis was conducted on 186 cases of pediatric Salmonella infection collected in Foshan Women and Children Hospital from January 1,2018 to December 31, 2022. The general information of the patient, time distribution characteristics, clinical characteristics, serotype distribution and drug resistance of pediatric Salmonella infection were analyzed. Results: The age distribution of 186 children with Salmonella infection was highest in the age group of 1-3 years old, accounting for 37.63%, and lowest in the age group of>6 years old, accounting for 1.61%. 33 cases occurred in 2018, 19 cases in 2019, 39 cases in 2020, 44 cases in 2021, and 51 cases in 2022. The overall number of Salmonella infection cases is showing an upward trend; There are salmonella infection cases all year round, and the highest incidence rate is in summer and autumn, accounting for 43.55% and 30.11% respectively. Fever, diarrhea, and defecation are the main symptoms, accounting for 90.32%,74.73% and 63.98%, respectively. The highest serotype B group was 118 cases, accounting for 63.44%. Through the analysis of the drug sensitivity test of 191 isolated Salmonella strains, only 3 strains (1.57%) were found to be non resistant to the detected antibiotics, while 157 strains (82.20%) were resistant to class 3 or more multidrug-resistant salmonella. The resistance rates of gentamicin, cefazolin, and cefotetan were all 100%. There was a statistically significant difference in the resistance rate of levofloxacin, ciprofloxacin and achromycin among different years(P<0 05). Conclusion: In recent years, the incidence of Salmonella infection in children in Foshan area has been on the rise. Children aged 1-3 are the main group, and summer and autumn are the peak seasons of the disease. The main serotype is Group B. Children infected with Salmonella are mainly characterized by fever, diarrhea, and defecation. The drug resistance of Salmonella is relatively severe, and relevant departments should pay attention to it. |
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