| 柴 茂,羊晰君,李 莹,王 蓓,黄姣姣.瑞芬太尼靶控输注对宫颈癌根治术患者麻醉苏醒质量、应激反应及Th1/Th2免疫平衡的影响[J].,2024,(9):1645-1648 |
| 瑞芬太尼靶控输注对宫颈癌根治术患者麻醉苏醒质量、应激反应及Th1/Th2免疫平衡的影响 |
| Effects of Remifentanil Target-Controlled Infusion on Anesthesia Awakening Quality, Stress Response and Th1/Th2 Immune Balance in Patients Undergoing Radical Resection of Cervical Cancer |
| 投稿时间：2024-01-06 修订日期：2024-01-27 |
| DOI：10.13241/j.cnki.pmb.2024.09.008 |
| 中文关键词: 瑞芬太尼 靶控输注 宫颈癌根治术 苏醒质量 应激反应 Th1/Th2免疫平衡 |
| 英文关键词: Remifentanil Target-controlled infusion Radical resection of cervical cancer Awakening quality Stress response Th1/Th2 immune balance |
| 基金项目:2022年上海市卫生健康委员会科研项目（202240294） |
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| 中文摘要: |
| 摘要 目的：观察瑞芬太尼靶控输注对宫颈癌根治术患者麻醉苏醒质量、应激反应及辅助T细胞（Th）1/Th2免疫平衡的影响。方法：按照随机数字表法将2023年1月到2023年6月期间我院接受的120例宫颈癌根治术患者分为舒芬太尼组（n=60，舒芬太尼麻醉）和瑞芬太尼组（n=60，瑞芬太尼麻醉）。对比两组的麻醉苏醒质量、应激反应指标[皮质醇（Cor）、去甲肾上腺素（NE）、血管紧张素1（Ang-1）、血管紧张素2（Ang-2）]、Th1/Th2免疫平衡指标[包括Th1、Th2及调节性T细胞（Treg）、Th1/Th2比值]，术后记录不良反应发生情况。结果：与舒芬太尼组相比，瑞芬太尼组的应激呼吸恢复时间、睁眼时间、拔管时间更短（P<0.05）。术后1 d，两组Cor、NE、Ang-1、Ang-2升高，但瑞芬太尼组低于舒芬太尼组（P<0.05）。术后1 d，两组Th1、Treg、Th1/Th2升高，但瑞芬太尼组低于舒芬太尼组；Th2下降，但瑞芬太尼组高于舒芬太尼组（P<0.05）。两组不良反应发生率组间对比未见差异（P>0.05）。结论：瑞芬太尼靶控输注用于宫颈癌根治术患者，可改善麻醉苏醒质量，减轻应激反应，调节Th1/Th2免疫平衡，且不增加不良反应的发生率，效果较好。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of remifentanil target-controlled infusion on anesthesia awakening quality, stress response and T helper cell (Th) 1/Th2 immune balance in patients undergoing radical resection of cervical cancer. Methods: 120 patients undergoing radical resection of cervical cancer in our hospital from January 2023 to June 2023 were divided into sufentanil group (n=60, sufentanil anesthesia) and remifentanil group (n=60, remifentanil anesthesia) according to the random number table method.The anesthesia awakening quality, stress response indicators [cortisol (Cor), norepinephrine (NE), angiotensin 1 (Ang-1), angiotensin 2 (Ang-2)], Th1/Th2 immune balance indicators [including Th1, Th2 and regulatory T cells (Treg), Th1/Th2 ratio] were compared between two groups, the incidence of adverse reactions was recorded after operation. Results: Compared with sufentanil group, the stress breathing recovery time, eye opening time and extubation time of the remifentanil group were shorter (P<0.05). 1 d after operation, Cor, NE, Ang-1 and Ang-2 in two groups increased, but remifentanil group were lower than those of sufentanil group (P<0.05). 1 d after operation, Th1, Treg and Th1/Th2 increased in two groups, but remifentanil group were lower than those of sufentanil group; Th2 decreased, but remifentanil group was higher than that of sufentanil group (P<0.05). There was no difference in the incidence of adverse reactions between two groups (P>0.05). Conclusion: Remifentanil target-controlled infusion for patients undergoing radical resection of cervical cancer, which can improve anesthesia awakening quality, reduce stress response, regulate Th1/Th2 immune balance, and do not increase the incidence of adverse reactions, the effect is better. |
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