| 张瑞剑,韩志桐,王 忠,赵卫平,孙 鹏,张彦娜,王诗秋,刘玮珉,金 毅,常 虹.全身免疫炎症指数联合血清CXCL5、CXCL12预测高级别脑胶质瘤患者术后复发的临床研究[J].,2024,(7):1396-1400 |
| 全身免疫炎症指数联合血清CXCL5、CXCL12预测高级别脑胶质瘤患者术后复发的临床研究 |
| Clinical Study of Systemic Immune Inflammatory Index Combined with Serum CXCL5 and CXCL12 in Predicting Recurrence in Patients with High Grade Glioma after Operation |
| 投稿时间：2023-12-06 修订日期：2023-12-30 |
| DOI：10.13241/j.cnki.pmb.2024.07.039 |
| 中文关键词: 高级别脑胶质瘤 全身免疫炎症指数 CXC趋化因子配体5 趋化因子配体12 复发 |
| 英文关键词: High grade glioma Systemic immune inflammatory index CXC chemokine ligand 5 Chemokine ligand 12 Recurrence |
| 基金项目:内蒙古自治区科技厅课题项目（2019GG043） |
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| 中文摘要: |
| 摘要 目的：探讨全身免疫炎症指数（SII）联合血清CXC趋化因子配体5（CXCL5）、趋化因子配体12（CXCL12）预测高级别脑胶质瘤（HGG）患者术后复发的价值。方法：选择2019年1月至2022年1月我院收治的169例行手术治疗的HGG患者。检测HGG患者中性粒细胞、淋巴细胞、血小板计数和血清CXCL5、CXCL12水平，并计算术前SII。术后随访1年，根据术后复发情况将HGG患者分为复发组（113例）和未复发组（56例）。多因素Logistic回归分析HGG患者术后复发的影响因素。受试者工作特征（ROC）曲线分析SII联合血清CXCL5、CXCL12预测HGG患者术后复发的价值。结果：复发组SII和血清CXCL5、CXCL12水平高于未复发组（P＜0.05）。HGG患者术后复发与年龄、术前KPS评分、WHO病理分级、手术切除范围、术后治疗情况有关（P＜0.05），与性别无关（P＞0.05）。多因素Logistic分析结果显示，WHO病理分级Ⅳ级、手术切除范围为未全切，SII升高和血清CXCL5升高、CXCL12升高是HGG患者术后复发的危险因素（P＜0.05）。SII、血清CXCL5、CXCL12单独检测预测HGG患者术后复发的曲线下面积分别为0.820、0.875、0.845，联合检测预测曲线下面积为0.964，高于单独指标检测预测。结论：HGG术后复发患者的SII升高、血清CXCL5升高、CXCL12升高，且WHO病理分级Ⅳ级、手术切除范围为未全切是HGG患者术后复发的危险因素，联合检测SII、血清CXCL5、CXCL12对HGG患者术后复发具有较高的预测价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the value of systemic immune inflammatory index (SII) combine with serum CXC chemokine ligand 5 (CXCL5) and chemokine ligand 12 (CXCL12) in predicting recurrence in patients with high grade glioma (HGG) after operation. Methods: 169 patients with HGG who were underwent operation treatment in our hospital from January 2019 to January 2022 were selected. Neutrophil, lymphocyte, platelet count and serum CXCL5, CXCL12 levels were detected in patients with HGG, and SII was calculated before operation. Patients were followed up 1 year, patients with HGG were divided into recurrence group (113 cases) and non recurrence group (56 cases) according to the recurrence after operation. The influencing factors of recurrence in patients with HGG after operation were analyzed by multivariate Logistic regression analysis. The value of SII combine with serum CXCL5 and CXCL12 in predicting recurrence in patients with HGG after operation were analyzed by receiver operating characteristic(ROC) curve. Results: The levels of SII and serum CXCL5 and CXCL12 in recurrent group were higher than those in non recurrent group(P<0.05). The recurrence of patients with HGG after operation was related to age, KPS score before operation, WHO pathological grade, surgical resection range and after operation treatment (P<0.05), and not to gender (P>0.05). Multivariate logistic analysis showed that, WHO pathological grade IV, surgical resection range were incomplete resection, elevated SII, elevated serum CXCL5, and elevated CXCL12 were risk factors for recurrence in patients with HGG after operation (P<0.05). The area under the curve of SII, serum CXCL5 and CXCL12 alone in predicting recurrence of patients with HGG after operation was 0.820, 0.875 and 0.845, respectively, the area under the curve of combined detection was 0.964, which was higher than that of single index detection. Conclusion: Elevate SII, elevate serum CXCL5, and elevate CXCL12 in recurrence patients with HGG after operation, and WHO pathological grade IV, surgical resection range were incomplete resection are risk factor in recurrence patients with HGG after operation. Combine detection of SII, serum CXCL5, and CXCL12 has a high predictive value for recurrence in patients with HGG after operation. |
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