| 张 文,童仁香,房红娟,陈 倩,柳娜娜,徐文付.小儿青翘颗粒联合注射用头孢西丁钠治疗急性上呼吸道感染患儿细胞免疫功能和炎性因子的影响[J].,2024,(6):1191-1194 |
| 小儿青翘颗粒联合注射用头孢西丁钠治疗急性上呼吸道感染患儿细胞免疫功能和炎性因子的影响 |
| Effects of Xiaoer Qingqiao Granules Combined with Eefoxitin Sodium for Injection on Cellular Immune Function and Inflammatory Factor in Children with Acute Upper Respiratory Tract Infection |
| 投稿时间：2023-08-06 修订日期：2023-08-30 |
| DOI：10.13241/j.cnki.pmb.2024.06.036 |
| 中文关键词: 小儿青翘颗粒 注射用头孢西丁钠 急性上呼吸道感染 细胞免疫功能 炎性因子 |
| 英文关键词: Xiaoer qingqiao granules Cefoxitin sodium for injection Acute upper respiratory tract infection Cellular immune function Inflammatory factor |
| 基金项目:安徽省卫健委基金资助项目（2016ek005） |
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| 中文摘要: |
| 摘要 目的：观察小儿青翘颗粒联合注射用头孢西丁钠治疗急性上呼吸道感染患儿细胞免疫功能和炎性因子的影响。方法：选择合肥市第二人民医院2019年10月到2023年1月期间收治的110例急性上呼吸道感染患儿，按照随机数字表法分为对照组（n=55）和研究组（n=55），对照组患儿接受注射用头孢西丁钠治疗，研究组患儿接受小儿青翘颗粒联合注射用头孢西丁钠治疗。对比两组疗效、临床症状恢复情况、细胞免疫功能指标、炎性因子水平，同时观察两组不良反应发生情况。结果：研究组的临床总有效率为96.36%高于对照组80.00%（P<0.05）。与对照组相比，研究组的咽痛消失时间、咳嗽消失时间、发热消失时间、鼻塞消失时间进一步缩短（P<0.05）。与对照组相比，研究组治疗2周后CD8+更低，CD3+、CD4+、CD4+/CD8+更高（P<0.05）。治疗2周后，研究组C反应蛋白（CRP）、降钙素原（PCT）、白细胞介素-6（IL-6）低于对照组（P<0.05）。两组不良反应发生率对比，未见统计学差异（P>0.05）。结论：小儿青翘颗粒联合注射用头孢西丁钠治疗急性上呼吸道感染患儿，可有效缓解临床症状，改善患儿的细胞免疫功能和炎性因子水平。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of xiaoer qingqiao granules combined with cefoxitin sodium for injection on cellular immune function and inflammatory factor in children with acute upper respiratory tract infection. Methods: 110 children with acute upper respiratory tract infection who were admitted to the Hefei Second People's Hospital from October 2019 to January 2023 were selected, and children were divided into control group (n=55) and study group (n=55) according to the random number table method, control group was treated with cefoxitin sodium for injection, and study group was treated with xiaoer qingqiao granules combined with cefoxitin sodium for injection. The efficacy, clinical symptom recovery, cellular immune function index and inflammatory factor level in two groups were compared, and the incidence of adverse reactions in two groups was observed. Results: The total clinical effective rate of the study group was 96.36%, which was higher than 80.00% in the control group (P<0.05). Compared with control group, the disappearance time of sore throat, disappearance time of cough, disappearance time of fever and disappearance time of nasal congestion in study group were further shortened (P<0.05). 2 weeks after treatment,compared with control group, CD8+ was lower, CD3+, CD4+ and CD4+/CD8+ were higher in study group (P<0.05). 2 weeks after treatment, the levels of C-reactive protein (CRP), procalcitonin (PCT) and interleukin-6 (IL-6) in study group were lower than those in control group (P<0.05). There was no significant difference in the incidence of adverse reactions between two groups (P>0.05). Conclusion: Xiaoer qingqiao granules combined with cefoxitin sodium for injection in treatment of children with acute upper respiratory tract infection could effectively relieve clinical symptoms, improve cellular immune function and inflammatory factor level. |
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