| 赵文麟,黄洪伟,范逸品,李 婧,李琰琴,吴慧青,赵文树.越鞠保和丸联合穴位埋线对肝胃不和型功能性消化不良患者胃动力指标、血清胃肠激素和胃蛋白酶原的影响[J].,2024,(6):1109-1113 |
| 越鞠保和丸联合穴位埋线对肝胃不和型功能性消化不良患者胃动力指标、血清胃肠激素和胃蛋白酶原的影响 |
| Effects of Yueju Baohe Pills Combined with Acupoint Thread Embedding on Gastric Motility Index, Serum Gastrointestinal Hormones and Pepsinogen in Patients with Functional Dyspepsia of Liver-Stomach Disharmony Type |
| 投稿时间：2023-10-23 修订日期：2023-11-18 |
| DOI：10.13241/j.cnki.pmb.2024.06.020 |
| 中文关键词: 越鞠保和丸 穴位埋线 肝胃不和 功能性消化不良 胃动力 胃肠激素 胃蛋白酶原 |
| 英文关键词: Yueju baohe pills Acupoint thread embedding Liver-stomach disharmony Functional dyspepsia Gastric motility Gastrointestinal hormones Pepsinogen |
| 基金项目:中国中医科学院科技创新工程项目（CI2021A00704） |
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| 中文摘要: |
| 摘要 目的：探讨越鞠保和丸联合穴位埋线对肝胃不和型功能性消化不良（FD）患者胃动力指标、血清胃肠激素和胃蛋白酶原的影响。方法：采用随机数字表法将2020年6月~2023年6月期间北京市鼓楼中医医院收治的123例FD患者分为对照组（61例）和研究组（62例）。对照组接受常规治疗联合穴位埋线治疗，研究组在对照组的基础上结合越鞠保和丸治疗。对比两组疗效、中医证候积分、胃动力指标、胃肠激素指标和胃蛋白酶原指标。结果：研究组的临床总有效率高于对照组（P<0.05）。治疗后研究组主症、次症、中医证候积分总分低于对照组（P<0.05）。治疗后研究组胃动素（MLT）高于对照组，生长抑素（SS）、胃泌素（GAS）低于对照组（P<0.05）。治疗后研究组餐后胃窦收缩频率（F）、收缩幅度（P）、运动指数（MI）高于对照组（P<0.05）。治疗后研究组胃蛋白酶原Ⅰ（PGⅠ）、胃蛋白酶原Ⅱ（PGⅡ）高于对照组（P<0.05）。结论：越鞠保和丸联合穴位埋线可有效改善肝胃不和型FD患者的血清胃肠激素和胃蛋白酶原水平，促进胃动力，进而改善胃肠功能。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of yueju baohe pills combined with acupoint thread embedding on gastric motility index, serum gastrointestinal hormones and pepsinogen in patients with functional dyspepsia (FD) of liver-stomach disharmony type. Methods: 123 FD patients who were admitted to Beijing Gulou Traditional Chinese Medicine Hospital from June 2020 to June 2023 were selected by random number table method, patients were divided into control group (61 cases) and study group (62 case). Control group was received routine treatment with acupoint thread embedding, and study group was treated with yueju baohe pill on the basis of control group. The efficacy, chinese medicine syndrome scores, gastric motility index, gastrointestinal hormones index and pepsinogen index were compared between two groups. Results: The total clinical effective rate in study group was higher than that in control group (P<0.05). The total scores of main symptoms, secondary symptoms and chinese medicine syndrome scores in study group were lower than those in control group after treatment (P<0.05). Motilin (MLT) in study group was higher than that in control group, and somatostatin (SS) and gastrin (GAS) were lower than those in control group after treatment (P<0.05). The postprandial gastric antrum contraction frequency (F), contraction amplitude (P) and exercise index (MI) in study group were higher than those in control group after treatment (P<0.05). Pepsinogen Ⅰ(PGⅠ) and pepsinogen Ⅱ(PGⅡ) in study group were higher than those in control group after treatment (P<0.05). Conclusion: Yueju baohe pills combined with acupoint thread embedding can effectively improve the serum gastrointestinal hormones and pepsinogen levels and promote gastric motility, further improve gastrointestinal function. |
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