| 程 诺,陈 亮,冯 洁,沈云海,潘勤聪.结肠癌组织LncRNA DLEU1、LncRNA NONHSAT017458的表达与临床病理特征与预后的关系[J].,2024,(6):1058-1062 |
| 结肠癌组织LncRNA DLEU1、LncRNA NONHSAT017458的表达与临床病理特征与预后的关系 |
| Relationship between the Expression of LncRNA DLEU 1 and LncRNA NONHSAT017458 in Colon Cancer Tissues and Clinicopathological Features and Prognosis |
| 投稿时间：2023-10-23 修订日期：2023-11-18 |
| DOI：10.13241/j.cnki.pmb.2024.06.009 |
| 中文关键词: 结肠癌 LncRNA DLEU1 LncRNA NONHSAT017458 临床病理特征 预后 |
| 英文关键词: Colon cancer LncRNA DLEU1 LncRNA NONHSAT017458 Clinicopathological features Prognosis |
| 基金项目:上海市闵行区自然科学研究课题（2020MHZ021）；上海市卫生健康委员会卫生行业临床研究专项项目（20204Y0390） |
|
| 摘要点击次数: 415 |
| 全文下载次数: 283 |
| 中文摘要: |
| 摘要 目的：探讨结肠癌组织中长链非编码核糖核酸（LncRNA）淋巴细胞白血病缺失基因１（DLEU1）、LncRNA NONHSAT017458表达与临床病理特征以及预后的关系。方法：选取2020年3月至2022年12月我院收治的136例结肠癌患者，取手术切除的癌组织和癌旁组织（距离癌旁5 cm以上）检测LncRNA DLEU1、LncRNA NONHSAT017458表达。比较不同病理特征结肠癌组织中LncRNA DLEU1、LncRNA NONHSAT017458表达差异，Kaplan-Meier生存曲线分析不同LncRNA DLEU1、LncRNA NONHSAT017458表达结肠癌患者生存率，Log-Rank检验生存率差异，单因素和多因素Cox风险比例回归分析影响结肠癌患者生存的因素。结果：癌组织LncRNA DLEU1、LncRNA NONHSAT017458表达均高于癌旁组织，差异有统计学意义（P＜0.05）。肿瘤直径≥4室cm、低分化、T3-4、N1-2的癌组织LncRNA DLEU1、LncRNA NONHSAT017458表达高于肿瘤直径＜4 cm、中和高分化、T1-2、N0中LncRNA DLEU1、LncRNA NONHSAT017458表达，差异有统计学意义（P＜0.05）。LncRNA DLEU1、LncRNA NONHSAT017458高表达结肠癌患者3年总生存（OS）率、3年无进展生存（PFS）低于LncRNA DLEU1、LncRNA NONHSAT017458低表达结肠癌患者，差异有统计学意义（P＜0.05）。多因素Cox回归分析显示高T分期、高N分期，高LncRNA DLEU1表达、高LncRNA NONHSAT017458表达是结肠癌患者预后不良的危险因素（P＜0.05）。结论：结肠癌组织中LncRNA DLEU1、LncRNA NONHSAT017458表达上调，高水平表达与结肠癌高T、N分期、低分化有关，可导致患者不良结局。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the expression of long-chain non-coding ribonucleic acid (LncRNA) lymphocytic leukemia deletion gene 1 (DLEU1) and LncRNA NONHSAT017458 in colon cancer tissues and clinicopathological features and prognosis. Methods: 136 colon cancer patients who were admitted to our hospital from March 2020 to December 2022 were selected, the expression of LncRNA DLEU1 and LncRNA NONHSAT017458 was detected in surgically resected cancer tissues and cancer adjacent tissues (more than 5 cm from the cancer adjacent tissues). The expression differences of LncRNA DLEU1 and LncRNA NONHSAT017458 in colon cancer tissues with different pathological features were compared, the survival rate of colon cancer patients with different LncRNA DLEU1 and LncRNA NONHSAT017458 expression were analyzed by Kaplan-Meier survival curve, the difference of survival rate were tested by Log-Rank test, the factors affecting the survival of colon cancer patients were analyzed by univariate and multivariate Cox risk proportional regression analysis. Results: The expression of LncRNA DLEU1 and LncRNA NONHSAT017458 in cancer tissues was higher than that in cancer adjacent tissues, and the difference was statistically significant (P<0.05). The expression of LncRNA DLEU1 and LncRNA NONHSAT017458 in cancer tissues with tumor diameter≥4 cm, low differentiation, T3-4 and N1-2 was higher than that in tumor diameter<4 cm, medium and high differentiation, T1-2 and N0, and the difference was statistically significant (P<0.05). The 3-year overall survival (OS) rate and 3-year progression-free survival (PFS) in colon cancer patients with high expression of LncRNA DLEU1 and LncRNA NONHSAT017458 were lower than those in colon cancer patients with low expression of LncRNA DLEU1 and LncRNA NONHSAT017458, and the differences were statistically significant (P<0.05). Multivariate Cox regression analysis showed that high T stage, high N stage, high LncRNA DLEU1 expression, and high LncRNA NONHSAT017458 expression were risk factors for poor prognosis in colon cancer patients(P<0.05). Conclusion: The expression of LncRNA DLEU1 and LncRNA NONHSAT017458 is up-regulate in colon cancer tissues, the high level of expression is relate to the high T, N stage and poor differentiation of colon cancer, which can lead to adverse outcomes in patients. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
