| 周秋意,胡洪平,王 刚,龙翔宇,林 俊.温针灸对寒湿痹阻型类风湿关节炎患者血清CXCR16、CCL19和TLR4/NF-κB信号通路的影响[J].,2024,(5):934-938 |
| 温针灸对寒湿痹阻型类风湿关节炎患者血清CXCR16、CCL19和TLR4/NF-κB信号通路的影响 |
| Effect of Warming Needle Moxibustion on Serum CXCR16, CCL19 and TLR4/NF-κB Signaling Pathway in Patients with Rheumatoid Arthritis of Cold Dampness Obstruction Type |
| 投稿时间：2023-08-23 修订日期：2023-09-17 |
| DOI：10.13241/j.cnki.pmb.2024.05.024 |
| 中文关键词: 温针灸 寒湿痹阻型 类风湿关节炎 CXCR16 CCL19 TLR4/NF-κB信号通路 |
| 英文关键词: Warming needle moxibustion Cold dampness obstruction type Rheumatoid arthritis CXCR16 CCL19 TLR4/NF-κB signal pathway |
| 基金项目:广东省中医药局科研项目（20183014） |
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| 中文摘要: |
| 摘要 目的：观察温针灸对寒湿痹阻型类风湿关节炎（RA）患者血清CXC趋化因子配体16（CXCR16）、趋化因子配体19(CCL19)和Toll样受体 4/核转录因子-κB（TLR4/NF-κB）信号通路的影响。方法：选择2020年6月~2022年6月期间佛山健翔骨伤医院收治的80例RA患者。按照随机数字表法将患者分为对照组（接受常规西医治疗，40例）和研究组（对照组的基础上结合温针灸治疗，40例）。对比两组评分[中医证候积分、28个关节疾病活动性评分（DAS28）]、实验室指标[RF、C反应蛋白（CRP）、红细胞沉降率（ESR）、抗环瓜氨酸抗体（抗CCP抗体）]、血清CXCR16、CCL19和TLR4/NF-κB信号通路相关指标的变化情况。结果：治疗后，两组中医证候积分、DAS28评分均下降，且研究组低于对照组，差异有统计学意义（P<0.05）。治疗后，两组类风湿因子（RF）、C反应蛋白（CRP）、红细胞沉降率（ESR）、抗环瓜氨酸抗体（抗CCP抗体）下降，且研究组低于对照组，差异有统计学意义（P<0.05）。治疗后，两组CXCR16、CCL19下降，且研究组低于对照组，差异有统计学意义（P<0.05）。治疗后，两组TLR4信使核糖核酸（mRNA）、NF-κB mRNA下降，且研究组低于对照组，差异有统计学意义（P<0.05）。结论：温针灸能够显著改善寒湿痹阻型RA患者的临床症状，调节血清CXCR16、CCL19水平，同时还可抑制TLR4/NF-κB信号通路激活。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effect of Needle warming moxibustion on Serum CXCR16, CCL19 and TLR4/NF-κB Signaling Pathway in Patients with Cold dampness obstruction type Rheumatoid Arthritis. Methods: 80 RA patients who were admitted to Foshan Jianxiang Bone Injury Hospital from June 2020 to June 2022 were selected. Patients were divided into control group (receiving conventional western medicine treatment, 40 cases) and study group (combined with warming needle moxibustion treatment on the basis of control group, 40 cases) according to the random number table method. The changes of scores [chinese medicine syndrome scores, 28 joint disease activity score (DAS28)], laboratory indexes [rheumatoid factor (RF), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), anti-cyclic citrullinated antibody (anti-CCP antibody)], serum CXCR16, CCL19 and TLR4/NF-κB signaling pathway related indexes were compared between two groups. Results: After treatment, the scores of traditional Chinese medicine syndromes and DAS28 scores decreased in both groups, and the study group was lower than the control group, the difference was statistically significant (P<0.05). After treatment, the levels of rheumatoid factor (RF), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and anti cyclic citrulline antibody (anti CCP antibody) decreased in both groups, and the study group was lower than the control group, the difference was statistically significant (P<0.05). After treatment, CXCR16 and CCL19 decreased in both groups, and the study group was lower than the control group, the difference was statistically significant (P<0.05). After treatment, two groups of TLR4mRNA and NF-κ B mRNA decreased and the study group was lower than the control group, the difference was statistically significant (P<0.05). Conclusion: Needle warming moxibustion can significantly improve the clinical symptoms of RA patients with cold dampness arthralgia, regulate the levels of CXCR16 and CCL19 in serum, and inhibit TLR4NF-κActivation of the B signaling pathway. |
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