| 范真真,孙鲁琨,彭 霈,尚明富,谢 倩,钟 萍.康复训练联合高压氧对高血压脑出血术后患者脑血管动力学、血管内皮功能和血清NSE、UCH-L1、GFAP的影响[J].,2024,(5):882-886 |
| 康复训练联合高压氧对高血压脑出血术后患者脑血管动力学、血管内皮功能和血清NSE、UCH-L1、GFAP的影响 |
| Effects of Rehabilitation Training Combined with Hyperbaric Oxygen on Cerebrovascular Dynamics, Vascular Endothelial Function and Serum NSE, UCH-L1 and GFAP in Patients with Hypertensive Cerebral Hemorrhage after Operation |
| 投稿时间：2023-08-08 修订日期：2023-08-31 |
| DOI：10.13241/j.cnki.pmb.2024.05.014 |
| 中文关键词: 康复训练 高压氧 高血压脑出血 脑血管动力学 血管内皮功能 NSE UCH-L1 GFAP |
| 英文关键词: Rehabilitation training Hyperbaric oxygen Hypertensive cerebral hemorrhage Cerebrovascular dynamics Vascular endothelial function NSE UCH-L1 GFAP |
| 基金项目:国家自然科学基金项目（81801191） |
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| 摘要 目的：观察康复训练联合高压氧对高血压脑出血术后患者脑血管动力学、血管内皮功能和血清神经元特异性烯醇化酶（NSE）、泛素羧基端水解酶（UCH-L1）、神经胶质纤维酸性蛋白（GFAP）的影响。方法：按照随机数字表法将2021年3月~2022年12月我院收治的112例行微创钻孔置管引流术的高血压脑出血术后患者分为对照组（n=56，接受常规康复训练）和观察组（n=56，对照组基础上结合高压氧干预）。对比两组量表评分[日常生活能力量表-改良Barthel指数（MBI）、Fugl-Meyer运动功能评定量表（FMA）、美国国立卫生研究院卒中量表（NIHSS）]、脑血管动力学指标[平均血流量（Qmean）、外周阻力（R）、平均血流速度（Vmean）]、血管内皮功能[内皮素-1（ET-1）、一氧化氮（NO）]、血清NSE 、UCH-L1、GFAP水平以及不良反应发生情况。结果：与对照组干预后相比，观察组MBI、FMA评分更高，NIHSS评分更低（P<0.05）。与对照组干预后相比，观察组Vmean、Qmean更高，R更低（P<0.05）。与对照组干预后相比，观察组NSE、UCH-L1、GFAP更低（P<0.05）。与对照组干预后相比，观察组NO更高，ET-1更低（P<0.05）。两组不良反应发生率对比未见差异（P>0.05）。结论：康复训练联合高压氧干预高血压脑出血术后患者，可有效改善脑血管动力学、血管内皮功能和血清NSE、UCH-L1、GFAP水平，减轻神经功能损伤，提高生活自理能力。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of rehabilitation training combined with hyperbaric oxygen on cerebrovascular dynamics, vascular endothelial function and serum neuron specific enolase (NSE), ubiquitin carboxyl terminal hydrolase (UCH-L1) and glial fibrillary acidic protein (GFAP) in patients with hypertensive cerebral hemorrhage after operation. Methods: 112 patients with hypertensive intracerebral hemorrhage who underwent minimally invasive drilling and drainage surgery at our hospital from March 2021 to December 2022 were divided into a control group (n=56, receiving routine rehabilitation training) and an observation group (n=56, combining hyperbaric oxygen intervention with the control group) according to the random number table method.The scale scores [activities of daily living scale-ｍodified Barthel index(MBI), Fugl-Meyer motor function rating scale (FMA), National Institutes of Health Stroke Scale (NIHSS)], cerebrovascular dynamics indexes [mean blood flow (Qmean), peripheral resistance (R), mean blood flow velocity (Vmean)], vascular endothelial function [endothelin-1 (ET-1), nitric oxide (NO)], serum NSE, UCH-L1, GFAP levels and adverse reactions were compared between two groups. Results: Compared with control group after intervention, the MBI and FMA scores in observation group were higher, and the NIHSS score was lower (P<0.05). Compared with control group after intervention, the Vmean and Qmean in observation group were higher, and the R was lower (P<0.05). Compared with control group after intervention, NSE, UCH-L1 and GFAP in observation group were lower (P<0.05). Compared with control group after intervention, NO was higher and ET-1 was lower in observation group (P<0.05). There was no difference in the incidence of adverse reactions between two groups (P>0.05). Conclusion: Rehabilitation training combined with hyperbaric oxygen intervention in patients with hypertensive intracerebral hemorrhage after operation, which can effectively improve cerebrovascular dynamics, vascular endothelial function and serum NSE, UCH-L1, GFAP levels, reduce neurological damage, and improve self-care ability. |
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