| 吴 扬,苏比努尔·艾尼瓦,高帅帅,古丽尼尕尔·阿布力孜,周 钰.针灸联合逍遥散合半夏厚朴汤治疗肝郁脾虚型抑郁症患者伴胃肠功能紊乱的临床疗效[J].,2024,(5):873-877 |
| 针灸联合逍遥散合半夏厚朴汤治疗肝郁脾虚型抑郁症患者伴胃肠功能紊乱的临床疗效 |
| Clinical Effect of Acupuncture and Xiaoxipopu Decoction in Patients with Gastrointestinal Dysfunction |
| 投稿时间：2023-08-07 修订日期：2023-08-30 |
| DOI：10.13241/j.cnki.pmb.2024.05.012 |
| 中文关键词: 针灸 逍遥散合半夏厚朴汤 肝郁脾虚型 抑郁症 胃肠功能紊乱 |
| 英文关键词: Acupuncture and moxibustion Xiaoyao San and Banxia Houpu Tang Liver depression and spleen deficiency type Depression Gastrointestinal dysfunction |
| 基金项目:国家自然科学基金项目（81960356） |
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| 中文摘要: |
| 摘要 目的：探讨针灸联合逍遥散合半夏厚朴汤治疗肝郁脾虚型抑郁症患者伴胃肠功能紊乱的临床疗效。方法：选取我院2020年5月到2023年5月收治的80例抑郁症伴胃肠功能紊乱患者作为研究对象，中医证型均为肝郁脾虚型，分为观察组与对照组，40例。对照组患者采取逍遥散合半夏厚朴汤治疗，观察组在对照组基础上增加针灸治疗，对比两组患者临床疗效，分别在治疗前后应用汉密尔顿抑郁量表（HAMD）、负性认知加工偏向问卷（NCPBQ）评价抑郁症状和负性认知情况，并对比治疗前后肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）、白细胞介素-6（IL-6）表达水平和胃动素（motilin，MTL）、生长抑素（SS）、胃泌素（GAS）相关血清肠胃激素表达水平，并采用世界卫生组织生活质量-100量表（WHOQOL-100）评估生活质量。结果：观察组治疗总有效率较对照组高（P＜0.05）；治疗前两组患者HAMD、NCPBQ评分对比无差异（P＞0.05），治疗后两组患者均降低，且观察组较对照组低（P＜0.05）；治疗前两组患者TNF-α、CRP、IL-6相关炎症因子和MTL、SS、GAS相关胃肠激素水平对比无明显差异（P＞0.05），治疗后两组患者TNF-α、CRP、IL-6、SS、GAS水平均降低，且观察组较对照组低，MTL水平升高，观察组较对照组高（P＜0.05）；两组患者治疗后生活质量相关评分均升高，且观察组较对照组高（P＜0.05）。结论：针灸联合逍遥散合半夏厚朴汤治疗肝郁脾虚型抑郁症伴胃肠功能紊乱疗效显著，可减轻患者抑郁情绪和负性认知，降低炎症反应，改善胃肠激素水平，提升患者生活质量。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical effect of acupuncture and moxibustion in patients with gastrointestinal dysfunction with liver depression and spleen deficiency. Methods: 80 patients with depression and gastrointestinal disorder admitted to our hospital from May 2020 to May 2023 were selected as the research subjects. All the patients were liver depression and spleen deficiency, which were divided into observation group and matched group, 40 cases. The matched group was treated with Pinxipopu soup, The observation group added acupuncture treatment to the matched group, Comparing the clinical efficacy of the two patient groups, The Hamilton Depression Scale (HAMD), the Negative Cognitive Processing Biases Questionnaire (NCPBQ) were applied before and after treatment, And compare the expression levels of tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukin-6 (IL-6) before and after treatment, and motilin (motilin, MTL), somatostatin, gastrin (SS) and GAS), Quality of life was also assessed using the World Health Organization Quality of Life-100 scale (WHOQOL-100). Results: The total response rate of the observation group was higher than that of the matched group (P<0.05); there was no significant difference in HAMD and NCPBQ scores between the two groups (P>0.05), the HAMD and NCPBQ scores were lower in the two groups after treatment, and the observation group was lower than the matched group (P <0.05); The comparison of TNF-α, CRP, IL-6, MTL, SS, and GAS between the two groups before treatment (P>0.05), and TNF-α, CRP, IL-6, SS, GAS decreased, and the observation group was lower than the matched group, and the MTL level increased, and the observation group was higher than the matched group (P<0.05); The scores increased after treatment and the observation group was higher than the matched group (P<0.05). Conclusion: Acupuncture and moxibustion combined with Xiaoyao Powder and Banxia Houpu Decoction has a significant effect on depression with liver depression and spleen deficiency accompanied by gastrointestinal dysfunction, which can reduce depression and negative cognition, reduce inflammatory reaction, improve the level of gastrointestinal hormone, and improve the quality of life of patients. |
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