| 罗琼玉,李文全,陈 磊,冯 磊,李明武,龙 慧.中药灌肠对宫颈癌急性放射性直肠炎患者临床疗效及血清IL-1β、IL-8、TNF-α水平的影响[J].,2024,(4):788-791 |
| 中药灌肠对宫颈癌急性放射性直肠炎患者临床疗效及血清IL-1β、IL-8、TNF-α水平的影响 |
| Effect of Traditional Chinese Medicine Enema on Clinical Efficacy and Serum IL-1β, IL-8 and TNF-α Levels in Patients with Acute Radiation Proctitis of Cervical Cancer |
| 投稿时间：2023-07-04 修订日期：2023-07-26 |
| DOI：10.13241/j.cnki.pmb.2024.04.037 |
| 中文关键词: 中药灌肠 宫颈癌 急性放射性直肠炎 临床疗效 IL-1β IL-8 TNF-α |
| 英文关键词: Traditional chinese medicine enema Cervical cancer Acute radiation proctitis Clinical efficacy IL-1β IL-8 TNF-α |
| 基金项目:湖南省中医药管理局科研课题（D2022087） |
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| 中文摘要: |
| 摘要 目的：探讨中药灌肠对宫颈癌急性放射性直肠炎（ARP）患者临床疗效及血清白介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）、白介素-8（IL-8）水平的影响。方法：选取2021年3月-2023年3月期间在邵阳市中心医院收治行放疗的宫颈癌ARP患者180例，采用随机数字表法将患者分为A组（常规治疗，n=90）和B组（A组的基础上接受中药灌肠，n=90）。观察两组临床疗效、放射损伤疗效、中医证候积分和IL-1β、IL-8、TNF-α水平变化情况，并对比不同放射性直肠炎分级患者的血清IL-1β、IL-8、TNF-α水平。结果：B组的临床总有效率高于A组（P<0.05）。两组治疗后黏液血便、腹痛、里急后重、稀便或便秘、肛门灼痛坠痛、口干口苦、尿赤等证候积分下降，且B组低于A组（P<0.05）。B组的放射损伤总有效率高于A组（P<0.05）。放射性直肠炎分级III级、Ⅱ级血清IL-1β、IL-8、TNF-α水平高于I级，且III级高于Ⅱ级（P<0.05）。两组治疗后血清IL-1β、IL-8、TNF-α水平下降，且B组低于A组（P<0.05）。结论：中药灌肠治疗宫颈癌ARP患者，可提高临床疗效，改善临床症状，可能与改善血清IL-1β、IL-8、TNF-α水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of traditional chinese medicine enema on clinical efficacy and serum levels of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) in patients with acute radiation proctitis (ARP) of cervical cancer. Methods: 180 patients with cervical cancer ARP who underwent radiotherapy in Shaoyang Central Hospital from March 2021 to March 2023 were selected, patients were divided into A group (conventional treatment, n=90) and B group (traditional chinese medicine enema on the basis of A group, n=90) by random number table method. The clinical efficacy, efficacy radiation injury, chinese medicine syndrome scores and serum IL-1β, IL-8 and TNF-α levels in two groups were observed. And compare of serum IL-1β, IL-8 and TNF-α levels in patients with different grades of radiation proctitis. Results: The total clinical effective rate in B group was higher than that in A group (P<0.05). The scores of mucous bloody stool, abdominal pain, tenesmus, loose stool or constipation, anal burning pain, mouth dry mouth bitter and red urine in two groups decreased after treatment, and those in B group were lower than those in A group (P<0.05). The total effective rate of radiation injury in B group was higher than that in A group (P<0.05). Serum IL-1β, IL-8 and TNF-α levels in grades of radiation proctitis III and II were higher than grade I, and grade III was higher than that of grade II (P<0.05). Serum IL-1β, IL-8 and TNF-α levels in two groups decreased after treatment, and those in B group were lower than A group (P<0.05). Conclusion: Chinese medicine enema in the treatment of cervical cancer ARP patients can improve the clinical efficacy and clinical symptoms, which may be relate to the improvement of serum IL-1β, IL-8 and TNF-α levels. |
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