| 郑云凤,李 铁,王 冠,陈 思,路皓婷.天麻钩藤饮加减治疗对脑梗死恢复期患者脑血流动力学、氧化应激和神经细胞因子的影响[J].,2024,(4):651-655 |
| 天麻钩藤饮加减治疗对脑梗死恢复期患者脑血流动力学、氧化应激和神经细胞因子的影响 |
| Effects of Modified Tianma Gouteng Decoction on Cerebral Hemodynamics, Oxidative Stress and Nerve Cell Factors in Patients with Cerebral Infarction Convalescence |
| 投稿时间：2023-07-04 修订日期：2023-07-27 |
| DOI：10.13241/j.cnki.pmb.2024.04.010 |
| 中文关键词: 天麻钩藤饮 脑梗死恢复期 脑血流动力学 氧化应激 神经细胞因子 |
| 英文关键词: Tianma gouteng decoction Cerebral infarction convalescence Cerebral hemodynamics Oxidative stress Nerve cell factor |
| 基金项目:国家中医药管理局课题项目（1996XZZX-NB011） |
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| 中文摘要: |
| 摘要 目的：探讨天麻钩藤饮加减治疗对脑梗死恢复期患者脑血流动力学、氧化应激和神经细胞因子的影响。方法：选取2020年4月~2022年12月期间于天津中医药大学第二附属医院治疗的108例脑梗死恢复期患者，按随机数字表法分为对照组和联合组，各为54例。对照组患者接受常规治疗，联合组在对照组基础上接受天麻钩藤饮加减治疗。对比两组中医证候评分、脑血流动力学、Barthel指数评分、氧化应激指标、美国国立卫生研究院卒中量表（NIHSS）评分、神经细胞因子。结果：与对照组治疗2个月后相比，联合组偏身麻木、半身不遂、舌强言蹇、头晕头痛、面红目赤、口苦口干等症状评分更低（P<0.05）。与对照组治疗2个月后相比，联合组NIHSS评分更低，Barthel指数评分更高（P<0.05）。与对照组治疗2个月后相比，联合组搏动指数（PI）更低，平均血流速度值（Vm）、收缩期血流速度峰值（Vs）更高（P<0.05）。与对照组治疗2个月后相比，联合组丙二醛（MDA）更低，超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）更高（P<0.05）。与对照组治疗2个月后相比，联合组髓磷脂碱性蛋白（MBP）更低，神经生长因子（NGF）、脑源性神经营养因子（BDNF）更高（P<0.05）。结论：天麻钩藤饮加减治疗脑梗死恢复期患者，可促进患者临床症状好转，降低神经功能损伤，改善脑血流动力学，减轻氧化应激，改善神经细胞因子分泌，提高生活自理能力。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of tianma gouteng decoction on cerebral hemodynamics, oxidative stress and nerve cell factors in patients with cerebral infarction convalescence. Methods: 108 patients with cerebral infarction convalescence who were treated in The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine from April 2020 to December 2022 were selected, and divided into control group and combined group according to random number table method, with 54 cases in each group. Patients in control group received routine treatment, and patients in combined group received tianma gouteng decoction on the basis of control group. The chinese medicine syndrome scores, cerebral hemodynamics, Barthel index score, oxidative stress index, national institutes of health stroke scale (NIHSS) score and nerve cell factor were compared between two groups. Results: Compared with control group 2 months after treatment, the chinese medicine syndrome scores such as hemianesthesia, hemiplegia, strong tongue, dizziness and headache, red face and red eyes and bitter and dry mouth in combined group were lower (P<0.05). Compared with control group 2 months after treatment, the NIHSS score in combined group was lower and the Barthel index score was higher (P<0.05). Compared with control group 2 months after treatment, combined group had lower pulsatility index (PI), higher mean blood flow velocity (Vm) and peak systolic blood flow velocity (Vs) (P<0.05). Compared with control group 2 months after treatment, combined group had lower malondialdehyde (MDA) and higher superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) (P<0.05). Compared with control group 2 months after treatment, combined group had lower myelin basic protein (MBP), higher nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) (P<0.05). Conclusion: Modified tianma gouteng decoction can promote the improvement of clinical symptoms, reduce neurological impairment, improve cerebral hemodynamics, reduce oxidative stress, improve the secretion of nerve cell factors and improve self-care ability in patients with cerebral infarction convalescence. |
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