| 杨雯雯,白 超,杨晶晶,李秋菊,王 宁.血清CTRP4、CTRP5、CTRP6与2型糖尿病合并冠心病患者冠状动脉病变的关系研究[J].,2024,(2):258-263 |
| 血清CTRP4、CTRP5、CTRP6与2型糖尿病合并冠心病患者冠状动脉病变的关系研究 |
| Relationship between Serum CTRP4, CTRP5, CTRP6 and Coronary Artery Disease in Type 2 Diabetes Patients with Coronary Heart Disease |
| 投稿时间：2023-06-04 修订日期：2023-06-27 |
| DOI：10.13241/j.cnki.pmb.2024.02.010 |
| 中文关键词: 2型糖尿病 冠心病 CTRP4 CTRP5 CTRP6 冠状动脉病变 |
| 英文关键词: Type 2 diabetes Coronary heart disease CTRP4 CTRP5 CTRP6 Coronary artery disease |
| 基金项目:省部共建中亚高发病成因与防治国家重点实验室开放课题（SKL-HIDCA-2020-19） |
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| 中文摘要: |
| 摘要 目的：探讨血清补体1q/肿瘤坏死因子相关蛋白（CTRP）4、CTRP5、CTRP6与2型糖尿病（T2DM）合并冠心病（CHD）患者冠状动脉病变的关系。方法：选取2021年3月～2021年7月我院收治的100例T2DM合并CHD患者为合并组，根据SYNTAX评分分为中重度病变组44例和轻度病变组56例，选取同期收治的100例单纯T2DM患者为T2DM组，另选取同期体检健康志愿者80名为对照组。采用酶联免疫吸附法检测血清CTRP4、CTRP5、CTRP6水平。采用Spearman相关性分析T2DM合并CHD患者SYNTAX评分与血清CTRP4、CTRP5、CTRP6水平的相关性，多因素Logistic回归分析T2DM合并CHD患者冠状动脉中重度病变的影响因素。结果：对照组、T2DM组、合并组血清CTRP4、CTRP5水平依次升高，CTRP6水平依次降低（P＜0.05）。Spearman相关性分析显示，T2DM合并CHD患者SYNTAX评分与血清CTRP4、CTRP5水平呈正相关（rs=0.820、0.833，P均＜0.001），与CTRP6水平呈负相关（rs=-0.838，P＜0.001）。多因素Logistic回归分析显示，T2DM病程延长和糖化血红白蛋白（HbA1c）、CTRP4、CTRP5升高为T2DM合并CHD患者冠状动脉中重度病变的独立危险因素，CTRP6升高为独立保护因素（P＜0.05）。结论：血清CTRP4、CTRP5水平升高和CTRP6水平降低与T2DM合并CHD患者冠状动脉病变加重独立相关，可能成为T2DM合并CHD患者冠状动脉病变评估指标。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum complement 1q/tumor necrosis factor related protein (CTRP) 4, CTRP5, CTRP6 and coronary artery disease in patients with type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD). Methods: 100 patients with T2DM combined with CHD who were admitted to our hospital from March 2021 to July 2021 were selected as the merged group. According to the SYNTAX score, they were divided into moderate to severe lesion group of 44 and mild lesion group of 56. 100 patients with pure T2DM who were admitted during the same period were selected as the T2DM group, and 80 healthy volunteers who underwent physical examination during the same period were selected as control group. Serum levels of CTRP4, CTRP5, and CTRP6 were detected using enzyme-linked immunosorbent assay. Spearman correlation analysis was used to investigate the correlation between SYNTAX score and serum levels of CTRP4, CTRP5, and CTRP6 in patients with T2DM and CHD. Multivariate logistic regression analysis was used to investigate the influencing factors of moderate to severe coronary artery disease in patients with T2DM and CHD. Results: Serum CTRP4 and CTRP5 levels were increased and CTRP6 levels were decreased in the control, T2DM and combined groups in that order (P＜0.05). Spearman correlation analysis showed that SYNTAX scores in patients with T2DM combined with CHD were positively correlated with serum CTRP4 and CTRP5 levels (rs=0.820, 0.833, all P＜0.001) and negatively correlated with CTRP6 levels (rs=-0.838, P＜0.001). Multi-factor logistic regression analysis showed that prolonged duration of T2DM and elevated glycosylated hemoglobin (HbA1c), CTRP4, and CTRP5 were independent risk factors for moderate to severe coronary artery disease in patients with T2DM combined with CHD, and elevated CTRP6 was an independent protective factor (P＜0.05). Conclusion: Increased serum CTRP4 and CTRP5 levels and decreased CTRP6 levels were independently associated with exacerbation of coronary artery lesions in patients with T2DM combined with CHD, and may be indicators for the assessment of coronary artery lesions in patients with T2DM combined with CHD. |
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