| 蔡宏桂,姚南珍,李思韵,吴雯静,魏爱生.茵陈五苓散联合利拉鲁肽对肥胖型2型糖尿病患者糖脂代谢、胰岛素敏感性和氧化应激的影响[J].,2024,(1):162-166 |
| 茵陈五苓散联合利拉鲁肽对肥胖型2型糖尿病患者糖脂代谢、胰岛素敏感性和氧化应激的影响 |
| Effects of Yinchen Wuling Powder and Liraglutide on Glucose and Lipid Metabolism, Insulin Sensitivity and Oxidative Stress in Obese Type 2 Diabetes Patients |
| 投稿时间：2023-08-06 修订日期：2023-08-27 |
| DOI：10.13241/j.cnki.pmb.2024.01.032 |
| 中文关键词: 茵陈五苓散 利拉鲁肽 肥胖型2型糖尿病 糖脂代谢 胰岛素敏感性 氧化应激 |
| 英文关键词: Yinchen Wuling Powder Liraglutide Obese type 2 diabetes Glucose and lipid metabolism Insulin sensitivity Oxidative stress |
| 基金项目:佛山市科学技术局项目（2020001005691）；佛山市高水平医院建设"登峰计划"（佛府办[2019]1号）；广东省医学科学技术研究基金项目（B2021340） |
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| 中文摘要: |
| 摘要 目的：探讨茵陈五苓散联合利拉鲁肽对肥胖型2型糖尿病（T2DM）患者糖脂代谢、胰岛素敏感性和氧化应激的影响。方法：选取2021年12月~2022年12月期间广州中医药大学附属佛山中医院收治的160例痰湿内蕴型肥胖T2DM患者。根据随机数字表法将患者分为对照组（利拉鲁肽治疗，80例）和研究组（茵陈五苓散联合利拉鲁肽治疗，80例）。对比两组疗效、糖脂代谢指标、肥胖相关指标、胰岛素敏感性、氧化应激和不良反应发生情况。结果：与对照组相比，研究组的临床总有效率更高（P<0.05）。研究组治疗后体质量指数（BMI）、空腹血糖（FBG）、腰臀比（WHR）、餐后2 h血糖（2hPG）、丙二醛（MDA）、糖化血红蛋白（HbAlc）、稳态模型胰岛素抵抗指数（HOMA-IR）、总胆固醇（TC）、黄嘌呤氧化酶（XO）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）较对照组低（P<0.05）。治疗后研究组稳态模型胰岛β细胞功能指数（HOMA-β）、高密度脂蛋白胆固醇（HDL-C）、超氧化物歧化酶（SOD）高于对照组（P<0.05）。两组不良反应发生率组间对比未见差异（P>0.05）。结论：茵陈五苓散联合利拉鲁肽治疗肥胖型T2DM患者疗效确切，可调节糖脂代谢水平，降低胰岛素敏感性，减轻氧化应激，且具有一定安全性，值得临床借鉴应用。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effects of Yinchen Wuling powder combined with Liraglutide on glucose and lipid metabolism, insulin sensitivity and oxidative stress in obese type 2 diabetes (T2DM) patients. Methods: 160 obese T2DM patients with phlegm dampness accumulation type who were admitted to Foshan Traditional Chinese Medicine Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine from December 2021 to December 2022 were selected. According to the random number table method, patients were divided into a control group (treated with liraglutide, 80 cases) and a study group (treated with Yinchen Wuling powder combined with Liraglutide, 80 cases). The efficacy, glucose and lipid metabolism indicators, obesity related indicators, insulin sensitivity, oxidative stress, and incidence of adverse reactions in the two groups were compared. Results: Compared with control group, the total clinical effective rate of study group was higher (P<0.05). Body mass index (BMI), fasting blood glucose (FBG), waist-to-hip ratio (WHR), 2 h postprandial blood glucose (2hPG), malondialdehyde (MDA), glycosylated hemoglobin (HbAlc), homeostasis model insulin resistance index (HOMA-IR), total cholesterol (TC), xanthoxine oxidase (XO), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) of study group after treatment were lower than those of control group (P<0.05). After treatment, homeostasis model islet β cell function index (HOMA-β), high density lipoprotein cholesterol (HDL-C) and superoxide dismutase (SOD) of study group were higher than those of control group (P<0.05). There was no difference in the incidence of adverse reactions in two groups (P>0.05). Conclusion: Yinchen Wuling Powder combined with liraglutide is effective in the treatment of obese T2 DM patients. It can regulate the level of glucose and lipid metabolism, reduce insulin sensitivity, reduce oxidative stress, and has certain safety. It is worthy of clinical reference and application. |
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