| 邵美丽,王少丽,吉 婷,贺云云,杨 虹,李 润.子宫颈机能不全孕妇血清松弛素、弹性蛋白表达意义及对妊娠结局的评估价值研究[J].,2023,(23):4596-4600 |
| 子宫颈机能不全孕妇血清松弛素、弹性蛋白表达意义及对妊娠结局的评估价值研究 |
| The Expression Significance of Serum Relaxin and Elastin in Pregnant Women with Cervical Imperfection and the Evaluation Value of Pregnancy Outcome |
| 投稿时间：2023-06-06 修订日期：2023-06-30 |
| DOI：10.13241/j.cnki.pmb.2023.23.039 |
| 中文关键词: 子宫颈机能不全 松弛素 弹性蛋白 妊娠结局 |
| 英文关键词: Cervical insufficiency Relaxin Elastin Pregnancy outcome |
| 基金项目:陕西省卫生健康委科研基金项目（2021A013） |
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| 中文摘要: |
| 摘要 目的：分析子宫颈机能不全孕妇血清松弛素、弹性蛋白表达意义及对妊娠结局的评估价值。方法：选择我院于2020年5月至2022年5月接诊的120例子宫颈机能不全孕妇作为观察组，另选同期的120例正常妊娠孕妇作为对照组。分析血清松弛素、弹性蛋白表达水平，及其与子宫颈机能不全孕妇宫口扩张宽度、宫颈长度的关系，观察血清松弛素、弹性蛋白在早产者与非早产者间的差异性，使用受试者工作特征曲线(ROC)下面积(AUC)评价血清松弛素联合弹性蛋白对早产及围产儿死亡的预测效能。结果：观察组血清松弛素水平较对照组高，弹性蛋白水平较对照组低（P＜0.05）；经Pearson相关性分析，子宫颈机能不全孕妇宫口扩张宽度与血清松弛素水平呈正相关，与弹性蛋白水平呈负相关（P＜0.05）；宫颈长度与血清松弛素水平呈负相关，与弹性蛋白水平呈正相关（P＜0.05）；在120例子宫颈机能不全孕妇中，早产42例、非早产78例；早产组血清松弛素水平高于非早产组，弹性蛋白水平低于非早产组（P＜0.05）；经ROC曲线分析，血清松弛素联合弹性蛋白预测子宫颈机能不全孕妇发生早产的AUC为0.910，预测围产儿死亡的AUC为0.943。结论：血清松弛素水平升高和弹性蛋白水平降低均与子宫颈机能不全有关，两者联合预测早产及围产儿死亡的效能较好，值得进一步研究应用。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the expression significance of serum relaxin and elastin in pregnant women with cervical insufficiency and their evaluation value for pregnancy outcome. Methods: A total of 120 pregnant women with cervical insufficiency admitted to our hospital from May 2020 to May 2022 were selected as observation group,and 120 pregnant women with normal pregnancy during the same period were selected as control group.The analysis of serum relaxin and elastin expression level and the relationship with uterine mouth expansion width and cervical length in pregnant women with cervical insufficiency, observe the difference of serum relatin and elastin between preterm and non-preterm patients, using the area under the subject working characteristic curve (ROC) (AUC) to evaluate the prediction efficacy of serum relaxin combined with elastin of preterm birth and perinatal death. Results: The serum relaxin level in observation group was higher than that in control group, and the serum elastin level was lower than that in control group (P<0.05). According to Pearson correlation analysis, the dilated width of uterine mouth was positively correlated with serum relaxin level, and negatively correlated with elastin level (P<0.05). Cervical length was negatively correlated with serum relaxin level, and positively correlated with elastin level (P<0.05). Among 120 pregnant women with cervical dysfunction, 42 were preterm and 78 were non-preterm. The serum relaxin level in preterm delivery group was higher than that in non-preterm delivery group,and the serum elastin level was lower than that in non-preterm delivery group (P<0.05). According to ROC curve analysis, the AUC of serum relain combined with elastin in predicting preterm delivery was 0.910 and that of perinatal death was 0.943. Conclusion: Both the increase of serum relaxin level and the decrease of elastin level are related to cervical insufficiency,the combined effect of the two is better in predicting premature birth and perinatal death,which is worthy of further study and application. |
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