| 侯 芳,李志瑶,刘瀚翔,张 熔,李 戈.急性淋巴细胞白血病患儿血清PGRN、XCL1与危险度分层和预后的关系[J].,2023,(23):4537-4541 |
| 急性淋巴细胞白血病患儿血清PGRN、XCL1与危险度分层和预后的关系 |
| Relationship between Serum PGRN, XCL1 and Risk Stratification and Prognosis in Children with Acute Lymphoblastic Leukemia |
| 投稿时间：2023-05-01 修订日期：2023-05-27 |
| DOI：10.13241/j.cnki.pmb.2023.23.027 |
| 中文关键词: 儿童 急性淋巴细胞白血病 PGRN XCL1 危险度分层 预后 |
| 英文关键词: Children Acute lymphoblastic leukemia PGRN XCL1 Risk stratification Prognosis |
| 基金项目:四川省卫生厅科研基金项目（080344） |
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| 中文摘要: |
| 摘要 目的：探讨急性淋巴细胞白血病（ALL）患儿血清颗粒蛋白前体（PGRN）、X-C基序趋化因子配体1（XCL1）与危险度分层和预后的关系。方法：选取2018年1月～2020年1月我院收治的102例ALL患儿为ALL组，根据危险度分层分为低危组27例、中危组42例、高危组33例，根据生存结局分为死亡组和存活组，另选取同期50名于我院体检健康儿童为对照组。采用酶联免疫吸附法检测血清PGRN、XCL1水平。采用多因素Logistic回归分析ALL患儿死亡的影响因素，受试者工作特征（ROC）曲线分析血清PGRN、XCL1水平对ALL患儿死亡的评估价值。结果：与对照组比较，ALL组血清PGRN、XCL1水平升高（P＜0.05）。低危组、中危组、高危组血清PGRN、XCL1水平依次升高（P＜0.05）。随访2年，102例ALL患儿死亡率为34.31%（35/102）。单因素分析显示，白细胞计数（WBC）、混合谱系白血病（MLL）重排、危险度分层、PGRN、XCL1为ALL患儿死亡的影响因素（P＜0.05）。多因素Logistic回归分析显示，WBC≥50×109/L、MLL重排阳性、危险度分层高危和PGRN、XCL1升高为ALL患儿死亡的独立危险因素（P＜0.05）。ROC曲线分析显示，血清PGRN联合XCL1评估ALL患儿死亡的曲线下面积（AUC）大于PGRN、XCL1单独评估。结论：ALL患儿血清PGRN、XCL1水平升高，与危险度分层和预后有关，血清PGRN联合XCL1评估ALL患儿预后的价值较高，可能成为ALL患儿预后辅助评估指标。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum progranulin (PGRN), X-C motif chemokine ligand 1 (XCL1), risk stratification and prognosis in children with acute lymphoblastic leukemia (ALL). Methods: 102 children with ALL who were admitted to our hospital from January 2018 to January 2020 were selected as the ALL group, and the children were divided into 27 cases in the low risk group, 42 cases in the medium risk group and 33 cases in the high risk group according to the risk stratification. They were divided into the death group and the survival group according to the survival outcome, another 50 healthy children who underwent physical examination in our hospital during the same period were selected as the control group. The serum PGRN and XCL1 levels were measured by enzyme-linked immunosorbent assay. The influence factors of mortality in children with ALL were analyzed by multivariate Logistic regression, and the evaluation value of serum PGRN and XCL1 levels for the death of children with ALL was analyzed by subject operating characteristic (ROC) curve. Results: Compared with the control group, the serum PGRN and XCL1 levels were increased in the ALL group (P<0.05). The levels of serum PGRN and XCL1 in the low risk group, medium risk group and high risk group increased sequentially (P<0.05). Follow up for 2 years, the mortality rate of 102 children with ALL was 34.31% (35/102). The univariate analysis revealed, white blood cell count (WBC), mixed lineage leukemia (MLL) rearrangement, risk stratification, PGRN and XCL1 were the influence factors for death in children with ALL (P<0.05). Multivariate Logistic regression analysis showed, WBC≥50×109/L, positive MLL rearrangement, high risk stratification and elevated PGRN and XCL1 were independent risk factors for death in children with ALL (P<0.05). ROC curve analysis showed, the area under the curve (AUC) of death in serum PGRN combined with ALL was greater than PGRN and XCL1 alone. Conclusion: The levels of serum PGRN and XCL1 in children with ALL increase, which relate to risk stratification and prognosis, and the combination of serum PGRN and XCL1 has a high value in evaluating the prognosis of children with ALL, which may become an auxiliary prognostic indicator for ALL patients. |
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