| 胡盛书,车丽娟,傅 娇,欧幸甘,邓 敦.基于Wnt/β-连环蛋白信号通路探讨少腹逐瘀汤治疗寒凝血瘀型子宫内膜异位症痛经的疗效及其机制[J].,2023,(22):4325-4328 |
| 基于Wnt/β-连环蛋白信号通路探讨少腹逐瘀汤治疗寒凝血瘀型子宫内膜异位症痛经的疗效及其机制 |
| Based on the Wnt/β-catenin Signaling Pathway to Investigate the Efficacy and Its Mechanism of Shaofu Zhuyu decoction in the Treatment of Cold Coagulation and Blood Stasis Type Endometriosis Dysmenorrhea |
| 投稿时间：2023-05-04 修订日期：2023-05-28 |
| DOI：10.13241/j.cnki.pmb.2023.22.025 |
| 中文关键词: Wnt/β-连环蛋白信号通路 少腹逐瘀汤 寒凝血瘀型 子宫内膜异位症 痛经 疗效 机制 |
| 英文关键词: Wnt/ β-catenin signaling pathway Shaofu Zhuyu decoction Cold coagulation and blood stasis type Endometriosis Dysmenorrhea Efficacy Mechanism |
| 基金项目:广东省中医药局科研项目（20171222） |
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| 中文摘要: |
| 摘要 目的：基于Wnt/β-连环蛋白信号通路探讨少腹逐瘀汤治疗寒凝血瘀型子宫内膜异位症（EMT）痛经的疗效及其机制。方法：选取2020年4月~2022年3月期间广州市中西医结合医院收治的197例EMT痛经患者，按照随机数字表法将患者分为对照组和研究组，例数分别为98例和99例，对照组患者接受常规治疗，研究组患者在对照组的基础上接受少腹逐瘀汤治疗。观察并对比两组患者的中医证候积分、痛经症状评分、疼痛视觉模拟（VAS）评分、疼痛持续时间、炎症因子、Wnt/β-连环蛋白信号通路相关指标。结果：与对照组治疗后相比，研究组治疗后的经行腹痛、持续性下腹疼痛、性交痛、小腹肿块、痛有定处、得温痛减、经色紫暗或有血块、带下量多色白、形寒肢冷等症状评分、痛经症状评分、VAS评分更低；疼痛持续时间更短；高迁移率族蛋白B1（HMGB1）、视黄醇结合蛋白 4（RBP4）、肿瘤坏死因子-α（TNF-α）、Wnt、T细胞因子-4（Tcf-4）、β-连环蛋白（β-catenin）更低（P<0.05）。结论：少腹逐瘀汤治疗寒凝血瘀型EMT痛经，可有效患者的临床症状，具有较好的临床应用价值，可能与降低炎症因子水平、调节Wnt/β-连环蛋白信号通路相关指标有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the efficacy and its mechanism of Shaofu Zhuyu decoction in the treatment of cold coagulation and blood stasis type endometriosis (EMT) dysmenorrhea based on Wnt/ β-catenin signaling pathway. Methods: 197 patients with EMT dysmenorrhea who were admitted to Guangzhou Integrated Traditional Chinese and Western Medicine Hospital from April 2020 to March 2022 were selected. According to the random number table method, the patients were divided into control group and study group, with 98 cases and 99 cases respectively. The patients in the control group received conventional treatment, and the patients in the study group received Shaofu Zhuyu decoction on the basis of the control group. The traditional Chinese medicine syndrome scores, dysmenorrhea symptom scores, visual analogue pain (VAS) scores, pain duration, inflammatory factors, Wnt/β-catenin signaling pathway related indexes of patients in the two groups were observed and compared. Results: Compared with the control group after treatment, abdominal pain during menstruation, persistent lower abdominal pain, pain during intercourse, lower abdominal mass, pain in fixed place, get warm and relieve pain, menstrual color purple or blood clots, morbid leucorrhea multi-colored white, cold in shape and cold in limbs symptom score, dysmenorrhea symptom score and VAS score were lower, pain duration was shorter, the high mobility group protein B1 (HMGB1), retinol-binding protein 4 (RBP4), tumor necrosis factor-α (TNF-α), Wnt, T cytokine 4 (Tcf-4), β-catenin (β-catenin) were lower in the study group after treatment(P<0.05). Conclusion: Shaofu Zhuyu decoction in the treatment of cold coagulation and blood stasis type EMT dysmenorrhea can effectively improve the clinical symptoms of patients, and has good clinical application value. It may be related to the decrease of inflammatory cytokines and the regulation of Wnt/ β-catenin signaling pathway. |
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